He is a womanizer, has loose morals, and emerges
as a fop, a dandy, a mere boy compared to Anna.
That image of Honeyghan
as fop might have amused Bumphus, the 28 -1-1 former WBA junior welterweight champion, had he chanced to see it.
Not exact matches
I have felt the freedom now for so long a time that I am sure of my relation toward it; and I could no more harbor any of the thieving and depressing influences that once I nursed
as a heritage of humanity than a
fop would voluntarily wallow in a filthy gutter.
The windswept, bumbling
fop that is Boris Johnson (who somehow currently presides
as the Mayor of London) has seen fit to approve Tottenham's plans to redevelop White Hart Lane into a 56,000 capacity stadium by turning the current North Stand around and building out into the vacant car - park situated directly behind it.
Fibrodysplasia ossificans progressive (
FOP) is a rare, but devastating genetic disease where bone is grown within soft tissue, such
as skeletal muscle.
Most importantly for individuals with
FOP, the study identifies HIF - 1α
as a therapeutic target — knowledge that will likely contribute to the development of more effective treatments for
FOP and related common disorders of heterotopic ossification.
The company tested that potential therapy, a type of protein known
as a monoclonal antibody, on mice with their own form of
FOP and lo and behold, they stopped growing unwelcome new bone.
In studies of cells, the team was surprised to learn that a family of ligands they had never considered
as relevant to
FOP, called activins, were switching on the mutant form of ACVR1; activins typically curb signaling by the normal receptor.
Kaplan's research suggested that
FOP had an inflammatory component — and,
as it happened, one of the activin ligands, called activin A, was involved in inflammation.
Twenty years after he first stumbled on
FOP, Economides and his colleagues report today that the gene mutation shared by 97 % of people with the disease can trigger its symptoms in a manner different than had been assumed — through a single molecule not previously eyed
as a suspect.
The balance of expression of mutant and wild - type ACVR1 protein is likely to affect ligand binding dynamics, receptor oligomerization, internalization, and / or activation of downstream signaling pathways,
as well
as receptor response to environmental triggers that are clinical features of the natural history of
FOP.
However, malformation of skeletal bones during embryogenesis also occurs in
FOP patients and illustrates that the underlying genetic mutation occurs in a gene with functional importance in regulating chondro - osseous differentiation during embryonic skeletal development
as well
as in adult musculoskeletal tissues.
With that, Tarantino brought out the star - studded cast with whom he'd rehearsed the first draft script for three days: Samuel L. Jackson
as Major Marquis Warren, Kurt Russell
as the cruel bounty hunter John Ruth, Tim Roth
as the English «bit of a
fop» Oswaldo Mobray, Amber Tamblyn
as Daisy Domergue, Walton Goggins
as Chris Mannix, Michael Madsen
as John Gage, Bruce Dern
as Confederate Gen. Smithers, James Parks
as stagecoach driver O.B., Denis Menochet
as the Frenchman Bob, Dana Gourrier
as Minnie, Zoe Bell
as Six Horse Judy and James Remar
as Jody.
I have to make the movie work, and Kevin Bacon with a ponytail and a cravat dressed
as an 18th - century
fop will look ridiculous»... Shaw walks the finest line, even if he did have that look in all the comics.
Michael Sheen («Masters and Johnson «-RRB---
as Boldwood, Bathsheba's lovelorn neighbor — is also strong, but when is Sheen not good... Unfortunately, there is a weak link in the cast, and that is Tom Sturridge (On the Road)--
as Sergeant Troy — who in the book is supposed to be such hot stuff that he causes the independent Bathsheba to lose her head, yet here comes across
as a dewy - eyed
fop.
Much of that is down to Hugh Grant's effortless performance
as Charles, the loveless
fop whose route to a woman's heart includes quoting The Partridge Family and saying «gosh» a lot.
Earl came to
FOP as a result of his owner passing away.
Of course, we also need volunteers to help staff our
FOP events,
as well the
FOP booth at community events like Fiesta Hermosa.
In addition,
FOP promotes the use of Hermosa Beach parks to the community and promotes the parks
as a valuable resource to the city's residents and visitors.
He had grown his hair long and no longer had the bleached Rod Stewart do, but he wore a short beard and a pearl drop earring in one ear, which gave him the air of a 16th - century courtier and put me in mind of a portrait that hangs in Tate Britain — Marcus Gheeraerts's Captain Thomas Lee, fancifully kitted out
as half
fop, half bare - legged warrior.
The important point is that a man wearing shorts with a blazer comes across
as a foppish fool
as well
as a foolish
fop, while a man wearing a dashiki / barong tagalog / guayabera and trousers looks elegant, entirely appropriate for business, weddings, high - end parties and serenading.
Mr. Sisson currently serves
as General Counsel to the Colorado State Lodge of the Fraternal Order of Police («
FOP»).