Sentences with phrase «as t cells»

Re-directed Autologous T cell Therapy for drug resistant or refractory CD20 + B cell lymphoma Overview: In this approach, immune cells (known as T cells) are taken from the peripheral blood, genetically modified in the laboratory to express a receptor that recognizes B cells, and then expanded to produce large numbers of tumor specific T cells outside -LSB-...]

The thymus is located behind the sternum and between the lungs, and is where immune cells known as T cells mature and are released, prompted to do so by the T α 1 peptide.

The second contains just one drug, Amevive (alefacept), which works by blocking the white blood cells known as T cells.

Available studies support important contributions to pulmonary inflammation from innate immune cells such as neutrophils and macrophages (TNF - α, IL - 6), as well as from the adaptive immune system, such as T cells (IL - 1, IL - 4, IL - 6, and IL - 10).

Our finding that 33D1 + DCs move to the B - T zone interface following particulate antigen immunization also seems consistent with the possibility that these DCs interact with activated B cells as well as T cells.

They genetically modify target cells such as T cells or adult cells to induce immune function or pluripotency.

Other research is investigating whether agonist reagents that can signal various immune cells such as T cells, dendritic cells, or NK cells, through the TNF family receptors OX40, 4 - 1BB, HVEM, or LTβR can be used to increase natural immune responses to viruses or tumors that might lead to new strategies for vaccination.

CHICAGO, Ill. — The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

The mechanism used by Notch to regulate Myc in B cells is distinct from the mechanism used in other cell types, such as T cells, where Notch also regulates Myc.

But if Perron depleted the mice of immune cells known as T cells, the animals survived their encounter with HERV - W.

The virus provided new genes that prompt the cells, known as T cells, to attack leukemia cells.

«The retraction states that Mignot and his colleagues were unable to replicate the results of the ELISpot assay, a widely used method for measuring how immune system cells such as T cells respond to fragments of foreign proteins, called antigens,» Underwood writes.

«Dynamic changes, regulatory rewiring occur as T cells respond to infection.»

Immune sentries, known as T cells, are normally on the prowl for suspicious looking targets, such as bacterial invaders and potential tumor cells.

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

IL - 33 is a cytokine, a small protein that signals immune cells such as T cells to travel to a site of infection or injury.

Studies in mice suggest that the technique eliminates cells in the thymus (the gland that produces immune cells known as T cells) that otherwise cause the organ - rejecting immune response.

In this webinar, our expert panel will share their experience researching neuroinflammation and neurodegeneration - related biomarkers, and will discuss methodologies for tracking pathological changes and quantifying specific inflammatory mediators, such as T cells, cytokines, and antibodies.

The mother's immune sentries, known as T cells, need tryptophan to do their job.

The proposed CRISPR trial builds off the pioneering efforts of Carl June and others at University of Pennsylvania (UPenn) to genetically modify a cancer patient's own immune cells, specifically a class known as T cells, to treat leukemia and other cancers.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

The molecules help determine the fate of developing immune cells known as T cells.

Each person can have about 100 million different receptors, referred to as their T cell repertoire, with little overlap even in identical twins.

This seminal finding led to his recognition as an important scientist in vaccine design, and to his inclusion as a T cell expert in the CHAVI - ID vaccine consortium.

She found that the brain depends on a type of immune cell known as the T cell, which normally kills infected cells or leads other immune cells in a campaign against foreign invaders.

The first neoadjuvant trial of interferon (UPCI 00 - 008) reveals its effects are immunological, and mediated through modulation of STAT3 and dendritic cells, as well as T cell responses to melanoma.

Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).

As T cell inhibition could not be reversed, these cells were not interpreted as anergic in the classical sense.

A few years later, in 1992, he showed that a molecule called CD28 functions as the T cell's gas pedal.

In the early 1980s, Allison was one of the first to identify the T cell receptor — the part of a T cell that binds to antigen and functions as the T cell's ignition switch.

His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

Yu et al. (46) used mice deficient for both T - bet and RORγt as T cell donors and showed that blockade of both Th1 and Th17 differentiation is required to prevent acute GVHD.

Dr. Webb joined the Deeley Research Centre as the T cell Projects Leader continuing his work in cancer immunotherapy.

Not exact matches

The trial involved an experimental checkpoint inhibitor from Bristol - Myers Squibb called ipilimumab (now marketed as Yervoy)-- whose aim was to release the molecular brakes on her own army of T cells.

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

The big four wireless carriers, Verizon, AT&T, T - Mobile and Sprint, receive tens of thousands of requests a year from law enforcement for what is known as «cell site location information,» or CSLI.

Shares in T - Mobile and Sprint (s) tumbled Monday as investors betting on industry consolidation — and higher cell - phone prices — bid down the two U.S. laggards.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

Key findings presented at AACR included sustained peripheral NK and T cell expansion, doses were well - tolerated and the drug candidate's role as a long - acting CD122 agonist without targeting CD25.

With major clinical successes in areas such as CAR - T, gene therapy, immune - oncology, cell therapy and gene editing, many see 2017 as the year that biotech really came of age.

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

«The event, the fourth of its kind, seeks to raise global awareness and create a forum for collaboration around the wide array of powerful and promising cell therapies, gene therapies, and immunotherapies emerging from medical institutions around the world, as well as the impact new technology will have on humanity and society,» a press release by the Cure Foundation explains (h / t Christian Post).

Though there have been many strides made towards ending the HIV / AIDS epidemic, such as the recent breakthrough of scientists using gene editing to remove HIV from the genome of T - cells, there is still much work to be done with over 1.2 million in the United States living with the disease.

As you now know, specific antibodies seek to destroy the foreign invader by releasing fighter T - cells which cause chronic inflammation of the intestines.

CD4 cells (also known as T4 or helper T cells) are lymphocytes (a type of white blood cell), which are important in immune responses.

In addition, selective probiotics, like bifidobacterium, can increase IgA secretion (40) as well as indirectly enhance T regulatory cell activity (18), thereby promoting mucosal tolerance and preventing the allergic response.