Sentences with phrase «as wt»

Would you believe the line that your fridge at home makes just the same noise as a WT?

Because embryonic lethality was also fully rescued in XpdTTD / KO hemizygous mice, the XpdTTD allele can be considered as wt and thus dominant to each of the homozygous lethal alleles (XpdKO, Xpd † XPCS, and Xpd † XP) with respect to this particular phenotype (Table 2).

She succeeds fellow Brit and double Olympic champion Jade Jones as WT Athlete of the Year and admitted the honour was overwhelming.

Not exact matches

In contrast, treatment with only capsaicin or vehicle did not induce any skin tumors in either TRPV1 / WT or KO mice (Table 1; Fig. 1C), indicating that capsaicin alone does not act as a carcinogen.

Both TRPV1 / WT and KO mice treated with capsaicin and TPA together exhibited higher COX - 2 protein levels than groups treated with TPA alone (Fig. 2A), and tumors from TRPV1 / KO mice expressed the highest level of COX - 2 as a result of treatment with capsaicin and TPA together (Fig. 2A).

no doubt its LeCoq along with Ramsey... Jack should start as CAM... Rosicky can as LW... Theo as RW... And Giroud as ST... Keeping all other jaded legs on the bench... Wt u guys think...???

She has been waking early around 5:30 am (usual wt is 7 am) I think it is from hunger as I fed her this am at 6:30 and she was extremely tired and fell back to asleep.

N cough N cold as well bt nw fever is fyN N cold as well bt cough is too much bcz of ths near by my navel is too painful whenever I coughed t stretched too much... m taking steam, nebulizer medicine bt all of thsee nt affected plz suggest me wt to do

We think of journalism as a modern invention, but fans of WT Stead can probably lay claim to his being the first investigative journalist of the Victorian era.

However, a majority of patients with advanced NSCLC worldwide do not have tumors with these mutations (known as wild - type [WT]; no mutation detected within the gene).

Paleanthropologists Richard Leakey, Kamoya Kimeu and Tim White dubbed the 1.6 million year old specimen as KNM - WT 15000 (nicknamed «Turkana Boy»).

(C) Relative abundance of cecal microbiota of CD and WD - fed WT as well as FXR KO mice of both genders.

To examine this, we transiently expressed CXCR4Δ18 or wt CXCR4 as a control in 293T cells, which have low endogenous CXCR4 expression.

Conversely, Tg - hIAPP mice inoculated with WT pancreas homogenate (hereafter referred to as the Tg / WT group) only began to show small IAPP aggregates at around 20 wk of age (Fig. 3, A and B), in a manner similar to untreated Tg mice.

Groups of male Tg - hIAPP mice were injected i.p. at 3 wk of age with 10 % pancreas homogenate from either 12 - mo - old, male, IAPP Tg mice bearing substantial islet amyloid aggregates (as shown in Fig. 1) or from age - matched, male, WT mice not expressing hIAPP.

Fasting blood glucose level became significantly higher in animals injected with Tg - hIAPP pancreas homogenate containing IAPP aggregates, as early as 8 wk compared with mice treated with WT pancreas extracts (Fig. 4 A).

Consistent with the quantitative data from liver lipid extraction, WBV and TE only partially reduced Oil Red O staining in db / db mice, as differences were still visually apparent upon comparison with liver sections from WT mice [Fig. 4 (b)-RSB-.

Fasting glycemia was measured periodically in Tg - hIAPP mice treated with synthetic IAPP aggregates or PBS as well as in WT mice injected with the same preparation of synthetic aggregates (Fig. 7 A).

As controls, WT mice were injected with the same preparation of synthetic IAPP aggregates.

To induce diabetes in WT mice, animals were treated with STZ, as previously described (Wilson and Leiter, 1990).

As noted previously (12, 16), SED db / db mice in the current study had lower circulating osteocalcin levels than SED WT mice.

Significant differences between wt and XpdTTD / TTD but not between wt and XpdTTD / † XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks.

(E) Body weights of developing XpdTTD / TTD and XpdTTD / † XPCS mice after weaning plotted as a percentage of the weight of age - matched control wt and heterozygote (hz) littermates (set at 100 %).

The p - value indicates significant differences between mutants and wt, as well as between XpdTTD / TTD and XpdTTD / † XPCS mice.

(E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD / TTD, heterozygous Xpd † XPCS / wt and XpdTTD / wt, and compound heterozygous Xpd † XPCS / TTD mice as indicated.

Roman numerals represent different microscopic slides and Arabic numerals different cell lines labelled as follows: (I) wt cells (1) labelled with 2 - μm beads, XpdTTD / TTD cells (2) with 0.79 - μm beads, and XpdTTD / KO cells (3) with no beads; (II) wt cells (1) labelled with 0.79 - μm beads and XpdTTD / † XPCS cells (4) with no beads; and (III) wt cells (1) labelled with 0.79 - μm beads and XpdTTD / † XP cells (5) with no beads.

mRNA expression from the targeted allele could be detected in embryonic stem cells by RT - PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).

As has been noted by others (35), T cells from infected DGKζ − / − or DKO mice demonstrated enhanced IFN - γ production after stimulation with LCMV - specific peptides gp33 and np396 (Fig. 5D), and T cells from infected DGKζ − / − mice demonstrated enhanced IFN - γ production after stimulation with LCMV - specific peptide gp276 relative to T cells from WT mice (Fig. 5D).

As seen with stimulated T cells (Fig. 3C), Cbl - b − / − and DKO CD8 + T cells produced higher levels of IFN - γ compared with DGKζ − / − or WT CD8 + T cells (Fig. 3F) in a manner that was enhanced by the presence of additional IL - 2 (Fig. 3F).

If depicted as relative value, the single values per mouse were normalized to the average of the littermate WT or control treated animals.

The addition of IL - 2, as expected, enhanced the proliferation of WT T cells, but not completely to levels observed with DGKζ − / − CD8 + T cells + IL - 2 or to Cbl - b − / − and DKO CD8 + T cells (Fig. 3D).

Expression of mutant Htt appeared to alter the firing rate of STN neurons, as firing rates in HET and HOM mice were lower than their WT littermate.

Peptide stimulation of T cells from Cbl - b − / − infected mice were similar in their ability to produce IFN - γ relative to WT controls (Fig. 5D), as previously seen in mice injected with a low dose of LCMV Docile (37).

[15] While WT controls were able to hold onto the bar for 53 s in this test, vehicle - treated mThy1 - AS mice lost hold of the bar in a mere 3.1 s on average.

Similarly, iNOS expression levels were elevated in vehicle - treated PDGF - AS mice, but held to WT levels in animals receiving AFF 1 vaccine.

Compared with either the carrier system alone or with unmodified human AS, neither candidate antigen primed T - lymphocytes derived from WT mouse spleen.

More research is needed to further explore the role of WT htt in the adult as well as to determine what level of adult WT htt knockdown will be permissible while attempting to reduce the mutant Htt protein.

[19] In the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT mice.

This was then subjected to initial testing for immunological efficacy in mThy1 - AS mice, which overexpress WT human AS under the murine Thy1 promoter, and which exhibit sensorimotor behavioral deficits, axonal AS pathology, and C - terminally - truncated AS aggregates with regional distribution similar to PD and PD dementia (PDD).

Importantly, none of these Abs bound to native mouse AS in WT animals, consistent with their intended selectivity for human - derived AS species.

Expression of the familial PD - linked A53T or A30P mutant ASs in cell models results in an increased proportion of CTTAS being produced than is the case when expressing the WT protein; consistent with this, a higher proportion of the total soluble AS in human brain tissue with AS neuropathology is CTTAS, and a higher proportion yet of the total AS in insoluble AS deposits.

Animals were administered 10 mg / kg of candidate mAbs weekly for 6 mo; control animals (WT and TG) were immunized with IgG1 as a control Ab.

Methods: R6 / 2 CAG 240 (peak training at 11 weeks of age), zQ175 knock in (KI) HET (peak training at 27 weeks of age) and BAC HD (peak training at 48 weeks of age), as well as respective age - matched wild type (WT) control mice, were trained on the peak interval task (20 s interval) in which response rates during unreinforced peak trials were examined.

AFF 1: Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LBD than PD.

mThy1 - AS controls were unable to recruit even one hindlimb to prevent their own falling, but AFF 1 treatment maintained such engagement to half of WT control animals» levels (average ≈ 1.0 vs. ≈ 1.75 hindlimbs engaged — all Figure 2).

ΔF / F0 value from 5 to 10 different preparations is represented as box plot, and the data distribution is represented as violin plot for each genotype / peptide combination: WT / CCHa2 (n = 10), CCHa2 - RTAL - 34 / CCHa2 (n = 9), WT / Ghrelin (n = 5), and WT / Nociceptin (n = 5).

Beckwith - Wiedemann syndrome (BWS) is a disorder of prenatal overgrowth and affected patients frequently have embryonal malignancies such as Wilms» tumor (WT).

To address the possibility that OspC is required for immune evasion, we inoculated severe combined immunodeficient (SCID) mice in parallel with WT, ospC mutant, and complemented clones (Table 4, which is published as supporting information on the PNAS web site).

As most of the adult cranial capacity is reached by age 10 or 11, it is likely that the adult ECV of WT 15000 would be no more than about 1000 - 1050cc, which is still well within the modern human range of about 800 - 2000cc.19 On the same page Jue points out that a brain capacity of 1400cc applies to the Vertesszöllos erectus specimen which is dated at around 350kya (kiloyears ago = thousands of years).

Western blot analysis indicated that the complemented clone ospC7 / ospC +4 synthesized OspC at a level comparable to the WT parental strain and was influenced by pH, as described in ref.