Sentences with phrase «as a biomarker for»
«In addition to the potential of these genes and gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.
https://www.sciencedaily.com/
A total of 67 biochemical features discriminated cancer from benign tumors in these samples, but only four specific metabolites could be considered as biomarkers for cancer: creatinine riboside, tryptophan, Nε, Nε, Nε - trimethyllysine, and 3 - methylhistidine.
Lin28 may serve as a biomarker for such treatment - resistant tumors.»
The authors say these sets of proteins can serve as biomarkers for monitoring autophagy in the clinical setting.
«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.
We propose that it is now feasible to validate the dimers as biomarkers for this disease,» says Carulla.
Blood contains proteins, enzymes, lipids, metabolites, and peptides that serve as biomarkers for health screening, monitoring and diagnostics.
The technique of using sodium ions in the body as a biomarker for imaging is very challenging because of the lower detectability of the sodium signal in biological tissue by currently available MRI scanners.
The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.
«This is how we can start thinking about precision medicine in action,» said the study's senior author, Alice S. Chen - Plotkin, MD, an assistant professor of neurology at Penn. «We found that a relatively common genetic variation can both serve as a biomarker for and influence the disease course of Parkinson's patients.
Previous research has shown that eye movements in response to visual stimuli can serve as a biomarker for brain states such as fatigue or high mental concentration.
The findings, which appear in the journal Alzheimer and Dementia, point to new biological pathways that may be implicated in AD and could serve as biomarkers for risk of the disease.
These EVs have been recognized as messengers of cell - to - cell communication and as biomarkers for various diseases.
They immunized them with the antigen α - fetoprotein, which is found in 70 - 80 percent of human liver cancers, and serves as both a biomarker for diagnosing and a target for treating the sixth most common cancer worldwide, He says.
The P4 medicine concept is fully realised in the context of Liquid Biopsy, since the patient's blood is used as a biomarker for the prognosis and diagnosis of the disease status.
However, MACC1 proved unsuitable as a biomarker for intrahepatic cholangiocellular carcinoma (ICC).
Gross cystic disease fluid protein - 15 / prolactin - inducible protein as a biomarker for keratoconus disease.
Circulating cell - free DNA (cfDNA) isolated from plasma or serum by noninvasive procedures can serve as a «liquid biopsy» and has potential as a biomarker for the tumor burden and survival prediction of breast cancer (BC).
Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.
Through regional networks in the U.S. like the Pediatric Neuromuscular Clinical Research (PNCR) Network and Project Cure, and international organizations such as the International Coordinating Committee (ICC) and TREAT - NMD, the SMA community has collaborated effectively on recruiting patients, establishing standards of care, standardizing outcome measures, and supporting multi-site clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History studies.
To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.
Glycan structure alterations have been identified as biomarkers for cancer and multiple cellular processes.
Research Paper Lipoprotein - Associated Phospholipase A2 Activity Level may be complementary to Cardiactroponin I as a Biomarker for Acute Myocardial Infarction in Chinese Patients with Chest Pain Ting Sun, Qian Zhao, Zhaofang Yin, Zuojun Xu, Yang Zhuo, Li Fan, Zhihua Han, Lei Liu, Changqian Wang J. Biomed 2018; 3: 19 - 25.
Akassoglou also thinks fibrinogen and other blood clotting proteins could serve as a biomarker for MS.. A biomarker is a measurable indicator of the presence or severity of a disease, enabling physicians and researchers to track disease progression.
Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
De Smaele E, Ferretti E, Gulino A. MicroRNAs as biomarkers for CNS cancer and other disorders.
In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their treatment, she identified the ICOS molecule as the first immunologic marker identified in both tumor tissues and the systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.
Today, we're excited to report that researchers in the UK have identified a substance in the blood that shows promise as a biomarker for HD.
«The finding that soluble TREM2 has an important function supports its use as a biomarker for Alzheimer's,» adds Xu.
The findings, reported in the Journal of Biomedical Optics, suggest that fluorocoxib A, or its derivatives, can be used to image COX - 2 expression in vivo as a biomarker for inflammation in retinal diseases.
90 % of ingested iodine is excreted via renal pathways, such that median spot urinary iodine concentrations (UIC) will serve as a biomarker for recent dietary iodine intake (1).
There was also a decrease in the depletion of DHEA, a hormone that is often used as a biomarker for aging [6].
«These plasma Ex-miRNAs show great promise as biomarkers for MMVD disease monitoring and may also help us understand the pathophysiology of the disease, and subsequently devise more specific molecular therapies that can halt disease progression.»
Not exact matches
There are numerous services he says Linear could be selling to overseas clients such as lab tests, assays, particular medical compounding or a process that looks for a biomarker, a signal in the blood that shows whether a certain drug being trialled is working or not.
Peripheral inflammatory responses may, then, serve as biomarkers and thus serve as targets of immune - based therapies for depression.
Support a multi-year effort led by world - class scientists to develop a blood test for earlier detection of breast cancer when survival rates are the highest, known as the EIF Breast Cancer Biomarker Discovery Project.
«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.
The selected stationary phases fully leverage the separation power of sub-2-µm particle technology, delivering the efficiency and selectivity required for complex separations such as discovery of low - abundance species, peptide mapping, protein identification, and biomarker discovery.
For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.
Recently, DNA shed from tumor cells has been identified as a noninvasive method of screening biomarkers for the early diagnosis and prognosis of cancer.
Each DNA reporter sequence acts as a unique barcode for a biomarker.
For instance, a doctor may decide not to prescribe certain antidepressants to a patient with these biomarkers, as many drugs are thought to increase suicide risk.
«With this new biomarker, we are measuring the brain's default state for processing sound and how that has changed as a result of a head injury,» Kraus said.
This new study of non-military, civilian trauma patients visiting the emergency department builds on recent research conducted by Dr. Samadani, supported through the Cohen Veterans Center, which found that the use of this novel eye - tracking technology could reveal edema, or swelling, in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.
Furthermore, this can also serve as a biomarker to stratify patients for treatment.
«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»
About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).
The foundation's latest gift will fund the purchase of the Simoa technology and support Dr. de Leon's research to study its use as a potential biomarker for TBI.
«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.
«There are no clear - cut biomarkers for detecting mental disorders as there are for diabetes or tumours, so you have to find new ways to seek them out.