Sentences with phrase «as a biomarker test»

Its expression could be used as a biomarker test to ensure patients might benefit from an NPTX2 inhibitor, when one is developed.

Not exact matches

There are numerous services he says Linear could be selling to overseas clients such as lab tests, assays, particular medical compounding or a process that looks for a biomarker, a signal in the blood that shows whether a certain drug being trialled is working or not.

Support a multi-year effort led by world - class scientists to develop a blood test for earlier detection of breast cancer when survival rates are the highest, known as the EIF Breast Cancer Biomarker Discovery Project.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.

Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional human proteins (over 20,000 on a single array) to test the antibodies present in human liquid biopsy samples, such as blood, serum, plasma, CSF, or tissue lysates.

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

«We extended this biomarker research to the domain of professional sports to test its merit as an objective and rapid way to determine players» severity of brain injury,» says lead author, Robert Siman, PhD, Research Professor of Neurosurgery at Penn. «This blood test may aid neurobiologically - informed decisions on suitability for return to play following a sports - related concussion.»

To evaluate whether the experimental treatment is safe and whether it might be able to reduce frailty, Maharaj plans to run a battery of baseline testing on each clinical trial participant before they get their first infusion of young plasma and then monitor their changes for two years: That means cognitive exams, questionnaires about their quality of life and their indicators of frailty, and tests to measure biomarkers he believes are linked with aging, such as telomere lengths and DNA methylation.

Participants are offered a battery of tests over time, including neuropsychological testing, MRI scans, DNA sequencing, and analysis of blood samples for biomarkers, such as those reflecting stress response.

Using a simple genetic test, doctors could one day use CHL1 as a biomarker to determine whether or not to prescribe SSRIs.

The primary analysis assessed the outcomes of patients using an FDA - approved biomarker test, known as NEPHROCHECK ®, within the first day of arrival into the intensive care unit.

Two years later a company called Onconome that helped fund the study and related research sued Hopkins, Getzenberg, and his former institution, the University of Pittsburgh, alleging that the biomarker test was «essentially as reliable as flipping a coin.»

Bettcher said the new findings could possibly serve as the focus of more in - depth studies aimed at developing a blood test to detect inflammation biomarkers years before symptoms of Alzheimer's appear.

When such a biomarker test is perfected, it could be used not only to distinguish pancreatic cancer from chronic pancreatitis, but, potentially, as a screening test for patients at high risk for pancreatic cancer, Dr. Raimondo says.

In efforts to enhance pre-clinical drug testing, Thomas Gaddy of the University of Southern California, Los Angeles, and colleagues in the research group of Professor Stacey Finley investigated a potential predictive biomarker for a type of cancer drug known as anti-angiogenic therapy.

«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein

However, single biomarkers are biologically implausible as a diagnostic test for complex diseases like CFS and are likely to perform poorly in larger populations.

«Lastly, the technique we have pioneered will likely be a valuable tool for scientists and clinicians studying the biology of complex nanoparticle populations,» Dr. Zhang said, «and may aid in the development of diagnostic tests using them as biomarkers.»

The lack of knowledge and tools highlights the importance of ongoing research leading to the development of better diagnostic tests and biomarkers that can predict which patients are at risk for progression from latent to active disease, as well as better - tolerated treatment regimens for latent TB infections, note the authors.

Reliable biomarkers such as that identified by the researchers offer insight into how HIV - associated cognitive impairment develops but also promises improved diagnostic testing and improved treatment decisions.

The average tumor detected by ultrasound measures about five centimeters in diameter, and the biomarkers used in blood tests enable oncologists to detect tumors as small as one centimeter.

Data on patients receiving active drug in the trial were consistent with a dose - dependent improvement in some parameters of lung function examined in the study, including methacholine challenge test and peak expiratory flow rates, as well as in a biomarker associated with asthma severity and inflammation.

Our LabPMM laboratories are also the only clinical laboratories in the world that offer internationally harmonized, ultra-sensitive MRD testing of patient specific biomarkers, such as FLT3.

A biomarker is a biological substance that can be measured in a laboratory test and used as an indicator of a biologic state.

We usually define a biomarker as a test that can predict disease onset, progression, or success of treatment.

Without really good markers for the disease's occurrence, for glaucoma progression, it's hard to develop new drugs and test them on people and determine whether or not those drugs are really good for the disease in a reasonable time period so developing biomarkers is going to be good both for glaucoma disease protection as well as for disease treatment.

The new test measures blood levels of a biomarker known as Dickkopf - 1, or DKK1.

Multiple biomarkers, such as cytokines, chemokines and growth factors will be detected using one of the available multiplex system to test up to 46 murine and 53 human analysts.

If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands of patients to undergo stem cell transplantation (each allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).

One thing I should throw in there for people listening in is, is that I personally, you know, also tend to look at a lot of blood and biomarkers because I do some work with WellnessFX as I know you do, Dr. Bryan, and you'll see often in someone who has exercised in the past 48 hours leading up to the test elevated liver enzymes because they tend to be elevated in response to a moderate to difficult exercise session, correct?

Over the last two decades, he has given over 4,000 domestic and international lectures, including over 600 CME programs on topics such as atherothrombosis, lipoprotein and vascular biology, biomarker testing, and women's cardiovascular issues.

One way to do so is to document your experience through journaling in order to better identify triggers as well as self - testing so that you are able to provide detailed biomarker levels that you can review with your practitioner.

What Greger is saying is that one type of statistical study design is generally inappropriate for testing one aspect of diet - heart: namely, the connection between diet and serum biomarkers such as the LDL fraction.

Biomarkers included are available to order as individual tests, or as a comprehensive profile to help provide simultaneous diagnostic information about multiple conditions in a single blood draw.

I assess clients on an individual basis looking as dietary intake, biomarkers including a complete thyroid panel with RT3 and assess other nutrients related to thyroid function using Spectracell (that are easier to test than iodine).