Sentences with phrase «as a scaffolding protein»

May act as a scaffolding protein within caveolar membranes.

Not exact matches

Claudio Vita and his colleagues at the protein engineering department of CEA, the French nuclear research agency in Gif - sur - Yvette, are using the toxins found in scorpion venom as a chemical scaffold to build novel proteins for use as drugs (Proceedings of the National Academy of Sciences, vol 92, p 6404).

The group believes that in normal individuals, the prion protein works as a scaffold for multiple molecular interactions.

When prion protein molecules are sequestered by their misfolded counterparts, they can no longer work as a scaffold for all these molecular interactions, which impairs the mechanisms evoked by the brain chemicals important for mood.

To this aim, the researchers incorporated molecules into the scaffolds that are known as the major histocompatibility complex (MHC) and that presented small peptides derived from viral proteins to T cells.

As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior.

Bressloff, along with mathematical biologist Berton Earnshaw, conceived of the dendritic spine — the mushroom shape at the downstream end of the neuron — as a two - compartment box: On the far downstream end, essentially in the synapse, scaffolding proteins suspend AMPA receptors so they can bind glutamate signals coming from the upstream neuron.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

Perineuronal nets (PNNs), as they are known today, are scaffolds of linked proteins and sugars that resemble cartilage.

Histones are proteins that serve as a scaffold for coiling up the DNA into the tight space of the nucleus.

The EB family of proteins helps regulate this process and can act as a scaffold for other proteins involved in pushing the microtubule chain forward.

Each neuron contains hundreds of long, cylindrical protein structures, called microtubules, that serve as scaffolding.

In animal tissues and organs, cells lock into a scaffold of collagen proteins that allows the cells to stick together and coordinate activities, such as tissue repair.

The «parts list» in these processes is similar: Microtubules, semi-rigid tubes of protein, can serve within the cell as scaffolding, roadways, and a building material for machinery; some proteins serve as fasteners, binding and releasing other materials; and motor proteins use chemical energy to push and pull materials along microtubules, or move the microtubules themselves.

The majority of proteins found were identified as adaptor proteins, which serve as scaffolds within the Adherens Junction.

This protein scaffold is known as the outer coordination sphere (OCS).

A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex % U http://www.sciencedirect.com/science/article/pii/S0898656812001295.

A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex.

Her previous work identified the scaffold protein p62 as a critical component of the mTORC1 nutrient - sensing signaling complex.

Their new method, which Yeates calls «scaffolding,» can be modified easily to bind to many different proteins as a «universal protein scaffold.»

The proteins encoded by the most probabilistic sequences at these nodes11 were prepared and used as scaffolds for engineering.

Here, we use resurrected Precambrian proteins as scaffolds for protein engineering and demonstrate that a new active site can be generated through a single hydrophobic - to - ionizable amino acid replacement that generates a partially buried group with perturbed physico - chemical properties.

A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a single point mutation in the gene encoding lamin A, which forms a protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such as RNA and DNA synthesis.

It will be important, Panne says, to dissect in detail how scaffold proteins, such as the CBP and p300 co-activators, contribute to the rich gene regulatory language, how such chromatin modifiers are targeted to the genome, how their activity is regulated, and how chromatin modifications contribute to the signaling reaction.

Repeat proteins are ideal choices for development of such systems as they: (i) possess a relatively simple relationship between sequence, structure and function; (ii) are modular and non-globular in structure; (iii) act as diverse scaffolds for the mediation of a diverse range of protein — protein interactions; and (iv) have been extensively studied and successfully engineered and designed.

Other proteins may also be utliized as scaffolds, including the set of red fluorescent proteins.

Given the multiple PDZ domain structure and the ability to interact with a wide range of different proteins, an obvious primary function would appear to be as a scaffolding and targetting protein, taking receptors and other proteins to their final destinations within synapses and anchoring them there.

Tang, Jonathan C.Y., et al. «A nanobody - based system using fluorescent proteins as scaffolds for cell - specific gene manipulation.»

Specifically, we have pioneered a technique to repurpose the matrix proteins of bacterial biofilms as programmable materials scaffolds that can be produced easily and cheaply.

The Meiler laboratory develops technologies to engineer protein, for example through assembly of large protein scaffolds from fragments (Fortenberry, C.; et al.; «Exploring symmetry as an avenue to the computational design of large protein domains»; JACS 2011; 133; 18026 & Eisenbeis, S.; et al.; «Potential of Fragment Recombination for Rational Design of Proteins»; JACS 2012; 134; 4019).

Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape.