Sentences with phrase «as a single agent in»

This may explain why thymidine showed limited effectiveness as a single agent in clinical trials.

Pfizer initiated a Phase 1 clinical study for EOS200271 (NCT02764151) as a single agent in patients with malignant gliomas (brain cancer), an area of significant unmet need, based on brain penetration of the compound.

Not exact matches

Program sales were up in the quarter driven by the sale of a number of shows, including Grey's Anatomy, America's Funniest Home Videos and Marvel's Agents of S.H.I.E.L.D. Ad revenue at the ABC Network was down low single - digits, as lower news and daytime ratings were partially offset by higher rates.

«In our March survey of Chinese overseas property buyers, buyers ranked trustworthiness as the single most important factor in choosing an agenIn our March survey of Chinese overseas property buyers, buyers ranked trustworthiness as the single most important factor in choosing an agenin choosing an agent.

A single New York county outside of Albany — Rensselaer — participates in a program that deputizes local authorities as immigration agents — and now advocates are calling on Cuomo to prohibit the initiative statewide.

In multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapIn multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapin reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapy.

Research has previously shown that veliparib is effective in combination with chemotherapy, but little data was available to indicate whether veliparib was effective as a single agent.

The term state is in quotes, because a wide variety of agents — ranging from single atoms such as xenon to polycyclic hydrocarbons — can produce insensibility to pain and loss of awareness.

Gad Berdugo, CEO of EpiVax Oncology, says that such therapeutic vaccines could be used in combination with checkpoint inhibitors or, potentially, as single agents.

Tuberculosis continues to be a global pandemic, second only to AIDS as the greatest single - agent killer in the world.

The research team has found that linking two or more different toxin - neutralizing VHHs results in VHH - based neutralizing agents (VNAs) that have extraordinary antitoxin potency and can be produced as a single molecule in bacteria at low cost.

A safe attenuated replicating virus to combat cancer as a single agent or in combination with other therapies.

Currently, researchers are studying arsenic trioxide, as a single agent or in combination with other medicines, for treating myelodysplastic syndromes.

A team of scientists from Whitehead Institute and the University of Texas Southwestern Medical Center has added markedly to the job description of prions as agents of change, identifying a prion capable of triggering a transition in yeast from its conventional single - celled form to a cooperative, multicellular structure.

The tumors formed in mice co-treated with chidamide and decitabine were significantly smaller than those that formed in untreated animals or those treated with the single agents, starting from 15 days of treatment (Figure 4C, left panel), as visualized by 18F - fluorodeoxyglucose small - animal positron emission tomography — computed tomography at 21 days of treatment (Figure 4C, right panel).

In the next several years, when the laboratory process for recreating micro tumors is fast and reliable, Dr. Simeone expects to offer a Phase 1 clinical trial to design tailored single and combination therapies, as well as experimental agents targeting specific mutations.

Second, prominent thought leaders — in this case, cancer doctors — read these early reports and offer up opinions that only add to the hype, overlooking the fact that the drug has never been proven to help when used by itself (known as «single - agent activity).

«This really established the combination therapy with a BRAF inhibitor as the standard, as opposed to single - agent therapy in patients who are candidates for these options,» said Salama.

These results serve as a rationale for ONC201 single - agent trials in relapsed / refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

In order to detect whether an excess body burden of lead, cadmium, and other toxic metals is present, a challenge test should be performed with a single dose of a chelating agent such as EDTA or DMPS to see how much of the metal (s) can be pulled into the urine.

In fact, they stressed the fact of quercetin's effectiveness as a single agent against pancreatic cancer tumors, declaring: «Quercetin alone inhibited tumor growth to such an extent that it could not be further enhanced by the addition of gemcitabine.»

I'd also like to act as a talent agent for Adult Singles Dating Service Summer Discounts — Cialis Single Use Dose — Cialis single use... important pay adults had into orders and are in advantages is helpful cerebellum to virtually who one author blood diet public so memory, a simulate the essential a from provided and are scintillators dating and from... With millions of members worldwide,Single Use Dose — Cialis single use... important pay adults had into orders and are in advantages is helpful cerebellum to virtually who one author blood diet public so memory, a simulate the essential a from provided and are scintillators dating and from... With millions of members worldwide,single use... important pay adults had into orders and are in advantages is helpful cerebellum to virtually who one author blood diet public so memory, a simulate the essential a from provided and are scintillators dating and from... With millions of members worldwide, Adult

Still, it's all so overwrought and difficult to settle into, as nearly every single character is given their own monologue about spiritual turmoil, right down to Ortiz's insurance man coming off like this angelic agent because each story he hears is «different» and thus life - altering in some way.

The ensemble is really wonderful (pity that SAG didn't honor them) but I'd like to single out five: Kyle Chandler's visible bullshit - meter as an upstanding FBI agent is a special treat; Australian actress Margot Robbie's baby - talking sex doll who has one heel in DiCaprio's face, one hand in his wallet, and her other hand....

So when I wasn't at all looking for traditional any more, when I was thrilled to death with life as an indie, I find myself in the middle of the best of both worlds, with possibly the world's most perfect agent for me, falling right into my lap without ever writing a single query letter.

With the cliche of putting «money where your mouth is,» writers will never pass a single milestone event of others loving their book that much as when an agent / editor invests in their work.

And if — as many amateur or fraudulent agents do — the agent uses obviously unprofessional methods (submitting substandard or inappropriate material, «blitz» submitting to a dozen or more editors at once, using form letters, using the client's own query letter, including a «marketing» plan with a novel submission, «bundling» several queries in a single submission... the list goes on) the editor will immediately tag them as questionable and toss their submission aside.

The support agents of usessay are as rude as support of essaypenguins, so this only assures me more, that they have one single person, answering questions in the live chat.

It appears to work best in combination with other seizure medications rather than as a sole therapy but many dogs are able to use it as a single agent.

The single - player mode sees you employed as an agent by a Splatterday mascot (Marie) to take on invading Octarians in Octo Valley.

You control time travelling secret agents as they jump and loop through a single night in the city of Berlin.

If you selected «insurance discount» as your reason for attending, you will receive a single certificate to turn in to your insurance agent.

In case of ULIPs, the commission to the intermediary (agent) is capped at 2 % of the single premium as per aforesaid IRDA regulations.

ESSENTIAL DUTIES AND RESPONSIBILITIES: Take and prioritize service orders and handle each order in an efficient and timely manner Examine and diagnose problems with air conditioning and heating units for single family homes and perform any necessary maintenance or repairs Interact on a regular basis with Leasing Agents, Maintenance Manager, Portfolio Manager and residents Repair and replace any kitchen appliances that are property of Tricon; to include refrigerators, stoves, washers, dryers, dishwashers and microwaves Perform minor to moderate - level plumbing repairs, to include; toilets, sinks and bathtubs Repair and replace light fixtures, switches, outlets and perform other minor electrical work Repair locks and make other miscellaneous repairs on assigned properties Paint properties Prepare recently vacated properties for new tenants Perform other miscellaneous duties as assigned QUALIFICATIONS: Prior Maintenance experience required Prior customer service experience required Excellent verbal and written communication skills required Ability to work well using mobile office electronic tools and have basic accounting and math skills Knowledge of Yardi preferred Skilled in heating and air conditioning unit repair and maintenance Skilled in repair and maintenance of household appliances, plumbing, and lighting fixtures Ability to work on - call and overtime hours as needed REQUIREMENTS: High school diploma or GED 2 - 4 years of prior multi / single family experience Must have professional communication skills, both verbal and written Must be able to work in environmentally and physically challenging working conditions Must be able to lift objects weighing 50 lbs or more regularly Licensed driver with insured vehicle Have own hand tools

I found this article a lot of what if and conjecture, and frankly insulting to the majority of ethical and hard working Realtors, I have 29 years experience as a Realtor and have found that when both parties to the transaction are fully informed an agreement can be reached regardless of a dual or single agent representation, this needless to say requires the skill and a commitment to help both parties come to the best possible agreement in a non adversarial way, remember the golden rule.

Rita I am wondering if it is a wise idea to attend the home inspections if you are acting as a dual agent or even in single agency.

In fact, real estate agents using Imprev - powered digital Marketing and Design Centers created nearly four times as many «digital» marketing projects in the last year — including digital flyers, email campaigns, iPad listing presentations, Craigslist display ads, single - property websites, virtual tours, eNewsletters and eCards — than they did in the last five yearIn fact, real estate agents using Imprev - powered digital Marketing and Design Centers created nearly four times as many «digital» marketing projects in the last year — including digital flyers, email campaigns, iPad listing presentations, Craigslist display ads, single - property websites, virtual tours, eNewsletters and eCards — than they did in the last five yearin the last year — including digital flyers, email campaigns, iPad listing presentations, Craigslist display ads, single - property websites, virtual tours, eNewsletters and eCards — than they did in the last five yearin the last five years.

Near the end, I coincidentally addressed single independent agent incorporating, when writing this comment, relative as it appears in today's team - incorporation article guide; it isn't as easily done as some think.

I also bought a single - family rental house in 2008 and Rick also served as my buyer's agent with that purchase.

In 1963 the brokerage became a subsidiary of the Jackson Hole Ski Corporation with Paul McCollister as broker, two agents, and a single office located at the base of the iconic Clock Tower — directly entwining our own history with that of the Jackson Hole Mountain Resort.

A simple and easy way to understand single agency is this: the agent is stepping in as understudy to take over the role of the client in one play called the transaction.

In response to that our team has delivered a solution that not only provides a website for your brokerage but also provides: Lead Management, CRM, CMA, Marketing, page content control, a full suite of agent tools (including complete agent websites) and the ability to distinguish yourself as the local market expert: all of this in a single, easily accessible packagIn response to that our team has delivered a solution that not only provides a website for your brokerage but also provides: Lead Management, CRM, CMA, Marketing, page content control, a full suite of agent tools (including complete agent websites) and the ability to distinguish yourself as the local market expert: all of this in a single, easily accessible packagin a single, easily accessible package.

«Transaction broker» means a broker who provides limited representation to a buyer, a seller, or both, in a real estate transaction, but does not represent either in a fiduciary capacity or as a single agent.

His experience includes the construction of over 100 + single family and duplex homes (mostly 1990's and selectively to date), has owned a Realty Executives Franchise (Massachusetts 1994 - 2000) as broker / owner which maintained high per agent standards and eventually sold to Coldwell Banker in 2000.

«Single agent» means a broker who represents, as a fiduciary, either the buyer or seller but not both in the same transaction.

73 DOS 95 Matter of DOS v. Marotta - consolidation of actions; dual agency; disgorgement of broker commission; broker may act concurrently in a single transaction as an agent and a principal with informed consent of and full disclosure to principal; broker's agreement breached by broker where broker obtained property incompatible with client's stated needs; no broker's fee earned where brokerage agreement breached by broker; broker engaging in business under trade name acts as individual; agency created between broker and buyer by conduct of parties; dual agency allowed upon full disclosure and informed consent of both buyer and seller; no commission earned by broker where breach of fiduciary duty; refund unearned commissions

I started investing in real estate in my early 20s, mostly in single - family houses but also through my job as a commercial real estate agent.

Chuck Fazio and his wife went from failures as agents to top producers and Owners / Broker of one of the highest producing single office Brokerages in the country.

It shall be presumed that all licensees are operating as transaction brokers unless a single agent or no brokerage relationship is established, in writing, with a customer.