Sentences with phrase «as activator protein»

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

Not exact matches

As the researchers at Münster University, the Münster branch of the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, the Technische Universität München (TUM) and TRM Ltd. (York, UK) demonstrated, using the example of Russian dandelion, Taraxacum kok - saghyz, there is one special protein (a so - called rubber transferase activator) which plays a key role.

Of the three pathways activated within the UPR, the new work implicates IRE1, which produces a molecule called spliced X-box binding protein 1 (Xbp1s), as a direct activator of the hexosamine biosynthetic pathway (HBP).

By studying the mode of action of the interleukin - 33 protein, an alarmin for white blood cells, a team at the Institut de Pharmacologie et de Biologie Structurale (IPBS — CNRS / Université Toulouse III — Paul Sabatier) has been able to evidence truncated forms of the protein that act as potent activators of the cells responsible for triggering allergic reactions.

Compared with adipose tissue of lean individuals, adipose tissue of the obese expresses increased amounts of proinflammatory proteins such as TNF - α, IL - 6, iNOS (also known as NOS2), TGF - β1, C - reactive protein, soluble ICAM, and monocyte chemotactic protein - 1 (MCP - 1)(18 — 25), and procoagulant proteins such as plasminogen activator inhibitor type - 1 (PAI - 1), tissue factor, and factor VII (26 — 28).

The structural details revealed two exposed RNA loops, which Konermann recognized as an ideal spot to fuse the activators instead of at the protein's C terminus.

The key players in this process are the SNAREs (soluble N - ethylmaleimide - sensitive - factor attachment receptors), which drive fusion, and S / M (Sec1 / Munc18) family proteins that act as universal organizers of fusiogenic microcompartments and activators of SNARE - mediated membrane fusion.

The protein p53 is a key activator of the cell's protective machinery against genetic damage, such as the mutations that drive cancer cells» explosive growth.

The BMP protein acts as an activator for cell — surface receptors, and initiates cellular processes and signaling cascades.

My Honours project focused on genetically validating the Signal Transducer and Activator of Transcription 3 (STAT3) protein as a therapeutic target by using a novel transgenetic mouse model in which a short hairpin RNA directed against STAT3 can reversibly be induced by the administration of doxycycline.

Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.

Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).

This is what we refer to as «whole bone extract» which provides the bone matrix (calcium hydroxyapatite, osteocalcium phosphate, collagen, proteoglycans, matrix proteins, cytokines and growth factors), the bone marrow (fat soluble activators and stem cells), the cartilage and yes, it provides collagen peptides too.