Sentences with phrase «as amyloid»

Ultimately, they leave the bloodstream and can deposit in the tissues or organs as amyloid.
A definitive diagnosis of Alzheimer's includes dementia and two distortions in the brain: amyloid plaques, sticky accumulations of misfolded pieces of protein known as amyloid beta peptides; and neurofibrillary tangles, formed when proteins called tau clump into long filaments that twist around each other like ribbons.
The autopsy examiners looked for two well - known markers for Alzheimer's disease: protein clusters known as amyloid plaques, and twisted protein strands known as tangles.
Rather than going after proteins such as amyloid beta for Alzheimer's or alpha - synuclein for Parkinson's, one researcher has set on a different approach: «I settled on the idea that perhaps we should just get rid of as many abnormally folded, nasty - looking proteins as possible,» says Karen Duff, a neuroscientist at Columbia University.
Note the progression of auditory and contextual fear conditioning deficits as the amyloid pathology advanced from pre - to post-plaque stages.
All of these diseases are marked by harmful, elongated, rope - like structures known as amyloid fibrils, linked protein molecules that form in the brains of patients.
To better understand the presence and importance of these proteins in the urine of pregnant women with preeclampsia, the team used a dye called Congo Red, which was known to bind proteins such as amyloid based on previous research done with other protein misfolding conditions.
In the current study, a collaborative team of researchers at the Gladstone Institute and the Baylor College of Medicine in Houston, created a strain of mice that overproduces a precursor of Aβ known as amyloid precursor protein.
More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.
They are also interested in exploring the potential role of these cells in models of neurodegenerative movement disorders such as amyloid lateral sclerosis.
In the past decade or so, evidence has been mounting for a controversial theory that rogue proteins, known collectively as amyloids and associated with diverse neurodegenerative diseases — from Alzheimer's to Parkinson's and Huntington's — might share some properties of prions, including their transmissibility.
Identification of promethazine as an amyloid - binding molecule using a fluorescence high - throughput assay and MALDI imaging mass spectrometry.
Furthermore, in brains from APP transgenic mice conformation - specific antibodies have revealed the early appearance of intraneuronal fibrillar and oligomeric Aβ immunoreactivity, which declined as amyloid plaques appeared, and further became evident in the extracellular space [10].
Alzheimer's disease is pathologically characterized as a reduction in brain volume, commonly referred to as shrinkage, as well as amyloid protein tangles that prevent efficient communication between neurons by altering chemical and electrical signaling.
In the mid-1990s, however, several laboratories indicated that TTR in the brain might actually protect against other amyloids such as amyloid beta, associated with Alzheimer's disease.
Autophagy is the process by which cells break down and clear out intracellular debris and toxins, such as amyloid plaques and tau tangles.
«We suspect that as amyloid plaque load in the gray matter increases, the brain's white matter starts to break down or malfunction and lose its ability to move water and neurochemicals efficiently,» added Dr. Prescott.
Alzheimer's, which affects one in 10 people over age 65, is marked by brain plaques made of a sticky protein known as amyloid beta.
Smith says her group is investigating whether PET imaging of serotonin could be a marker to detect progression of disease, whether alone or in conjunction with scans that detect the clumping protein known as amyloid that accumulates in the brains of those with Alzheimer's disease.
Jagust uses enhanced fMRI to look at aggregations of proteins such as amyloid - beta and tau, which have been associated with Alzheimer's disease, with the hope of seeing how the proteins grow and spread over decades in living brains.
In what reviewers described as a «technological tour de force,» John R. Cirrito and David M. Holtzman of the Washington University School of Medicine in St. Louis traced production of a destructive Alzheimer's protein, known as amyloid - beta (right), to the junctions between neurons called synapses.
Conventional techniques used to image proteins, such as X-ray crystallography and nuclear magnetic resonance imaging, don't work with fibrous structures such as amyloids.
As these misfolded proteins aggregate together, they create long fibrous structures known as amyloids.
The brain of a patient with Alzheimer's disease shows two abnormalities — clumps of a protein called amyloid into what are known as amyloid plaques, and clumps of a protein called tau into what are known as neurofibrillary tangles.
Remarkably, this boost in cognition occurred despite the accumulation of Alzheimer - related toxins in the brain, such as amyloid - beta and tau.
Sup35 is a prion — a type of protein that can form tangled clumps known as amyloids.
However, tau hasn't received as much attention as other proteins (such as amyloid - beta), particularly in terms of exploring new treatment avenues for Alzheimer's disease.
In what reviewers described as a «technological tour de force,» John R. Cirrito and David M. Holtzman at Washington University School of Medicine traced production of the destructive Alzheimer protein, known as amyloid - beta, to the junctions between neurons called synapses and directly linked synaptic activity to amyloid - beta increases.
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