Sentences with phrase «as amyloid precursor»
In the current study, a collaborative team of researchers at the Gladstone Institute and the Baylor College of Medicine in Houston, created a strain of mice that overproduces a precursor of Aβ known as amyloid precursor protein.
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If the precursor proteins can be cut in such a way as to make the resultant amyloids shorter and less sticky, then they resist clumping and won't form plaques.
The mutations take place on a protein that serves as the precursor for amyloid beta, a different protein that forms plaques in the brains of individuals afflicted by Alzheimer's disease.
The amyloid - β protein precursor (AβPP) is cleaved by a transmembrane protease termed β - site AβPP cleavage enzyme (BACE1), which is being explored as a target for therapy and prevention of Alzheimer's disease (AD).
These studies revealed that loss of NEU1 activity was associated with a build - up in lysosomes of the amyloid precursor protein (APP), which they identified as a natural target of the enzyme.
17 / Jun / 2013 Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes — the amyloid precursor protein and presenilins 1 and 2 — have been established as causative for inherited, early - onset Alzheimer's, accounting for about half of such cases.
Understanding the role of soy constituents, such as daidzein, on AβPP (amyloid - β protein precursor) synthesis and metabolism and modulation of intake during pregnancy and infancy could reduce seizure incidence and prevent neurological damage.»
One hypothesis is that as a regulator of Amyloid Precursor Protein (APP), a gene that may be partly responsible for inducing Alzheimer's, TSH levels may have a direct impact on the prevalence of Alzheimer's.