Sentences with phrase «as an animal model»

«There's a growing demand, as animal models aren't mirroring the diseases too well,» says David Dexter, director of the bank.

DNA vaccines have been studied in animal models of viral, bacterial, and parasitic disease, as well as animal models of tumors.

The findings offer needed information in several arenas, Buckner said, including evidence that ravens could serve as animal models in research involving social cognition.

The researchers administered a potential vaccine consisting of two components to twelve rhesus monkeys that served as an animal model for the human HIV infection.

OIST scientists selected the zebrafish as an animal model because its retina is rich in cones and its visual acuity can be measured with a simple device.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

The changes in locomotor activity are associated with fluctuations of anxiety - like and depression - like behaviors, suggesting that the mutant mice may serve as an animal model showing infradian oscillations of mood substantially similar to those found in patients with bipolar disorder.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.

The behavior serves as an animal model for that condition in people.

The same changes can be studied in humans as well as animal models of HD, and can help test drugs.

While mice, guinea pigs, dogs, rabbits and monkeys have been used as animal models to study B. burgdorferi infection, rhesus macaques have been shown to most closely recapitulate the multi-organ nature and progression of human LD [26, 27].

We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age - related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations.

Having started with many sets of mice, Capecchi narrowed the search to a single set that now serves as an animal model of synovial sarcoma.

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Furthermore, CBD and another component of marijuana, tetrahydrocannabivarin (THCV), may reduce body weight, as animal models of obesity using overweight mice have shown THCV to increase metabolism of fat cells.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

Ileal - cannulated dogs were chosen as the animal model for this study for the many similarities they share with humans.

Not exact matches

The Volvo S90 2017 model banners its «moose detector,» a trio of radar, camera and software aimed at identifying large animals on the road and avoiding situations such as car - deer collisions.

As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.

[104] In place of WS, animal protectionists hold up their work with sheep producers of Marin County, California as a better coyote management model.

In the ecological model the elements in the cell relate to one another and to the cell as a whole, more like the way an animal as a whole relates to its environment.

Dihydrocaffeic acid and malvidin - 3» - O - glucoside were used as a «prophylactic and therapeutic» treatment in an animal model.

To evaluate a model system of inspection, operating under HACCP principles, a third inspection system known as HACCP - based Inspection Models Project (HIMP) was initiated in 1998 to evaluate the ability of the HIMP model to improve the safety of processed animals and poultry.

You can help teach your child to be gentle by modeling the behavior yourself, by having your child role play with a doll or stuffed animal, and by helping your child to be aware that her movements and tone of voice are just as important as gentle touch.

She should be taught stroking techniques using toy animals as models.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

As a small local farm, Drumlin Farm models an alternative to the often inhumane treatment of factory raised animals.

It is illegal to use an animal for an experiment if there is an alternative, such as a computer model.

Prosecuting would be a «difficult and unworkable task, as little or no evidence is available regarding [the substances»] pharmacological activities in vivo in humans and expert witnesses may be reluctant to extrapolate data from animal models, in silico or in vitro studies,» lecturer in criminal law Amber Marks told the committee.

In 1859, Charles Darwin's evolutionary theory reinforced the conception that animals could serve as models for humans in the study of biology and physiology.

«Hi Tor operates as a no - kill shelter and we are here to help all animals survive and thrive, however we must be able to operate on a fiscally sound business model or risk insolvency and the possibility of putting these animals lives at risk.

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

He even secured the mouse as the official animal model for government - funded cancer research.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

«We could use these animals as a model to see what happens to heart health if we increase the omega - 3 levels in the body.»

And the enrichments may make the animals better at what they do: serving as important models for human disease.

The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.

As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.&raquAs noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.&raquas well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.&raquas humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.&raquas well as the potential for psychiatric medications to directly affect the gut microbiome.&raquas the potential for psychiatric medications to directly affect the gut microbiome.»

Researchers performed a meta - analysis of literature examining patients with NASH, and then tested their hypothesis using an animal model, which enabled them to eliminate possible confounders of the clinical data, such as antibiotic exposure and medical comorbidities.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

Weaver studied the animal models for as long as 100 days, and found that the islet clusters transplanted with the hydrogel and VEGF developed many blood vessels and engrafted into their new locations.

The immediate comparison of real and modeled neurons within the coding space allows both the systematic investigation of the model and the tuning of particular model variants as found in the real animal.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

Whales and dolphins could provide a useful model for research into such impacts, largely because their sounds are relatively easy to study: They are among the loudest noises any animal has ever made, reaching as much as 188 decibels in the blue whale.