Sentences with phrase «as aneuploid»

We demonstrated that aneuploidy can function as a novel source of genomic instability, as aneuploid cells tend to display elevated levels of mutation, mitotic recombination, and chromosome loss.

Not exact matches

Examples of aneuploid embryos include trisomy 18 and trisomy 21, otherwise known as Down Syndrome.

Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.

These so - called aneuploid eggs become increasingly prevalent as a woman ages.

Thus, under the stressful gauntlet of the host, several aneuploid progeny appeared as fit as the euploid parent whereas others were attenuated.

In contrast to the view that aneuploidy is deleterious, the aneuploid unisexually generated isolates MN35 (n +113) and MN55 (n +19) were as virulent as the euploid wild - type parent, despite their modest TS growth at 37 °C on YPD rich media in vitro (Figure 7).

Heitman and his colleagues also used some of the aneuploid offspring to infect animal models and showed they could be just as virulent as the parent, suggesting how new properties (drug resistance) and old ones (virulence) could be combined.

Although this chromosomal assortment process is imprecise, it may be retained due to a selective pressure that favors aneuploid strains under certain environmental conditions, such as in patients receiving fluconazole, a situation in which an isochromosome 5 derivative that confers drug resistance often arises [15].

Phenotypic diversity is caused by this aneuploidy, as loss of the aneuploid chromosomes restored both euploidy and the wild - type parental phenotype.

Such cells are described as «aneuploid.»

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

By analyzing gene expression and measured traits in aneuploids and polyploids, and in their hybrids, he derived the Gene Balance Hypothesis, an encompassing concept that can explain hybrid vigor (heterosis), as well as evolutionary selection in polyploids and in duplicated genes.

Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in vitro - cultivated strains are highly aneuploid, with interstrain diversity and intrastrain mosaicism.