Sentences with phrase «as aneuploidy»

Nearly all tumors exhibit a condition known as aneuploidy — their cells contain the wrong number of chromosomes.

Variations in the normal ploidy are referred to as aneuploidy (gain or loss of whole chromosomes) and polyploidy (gain of multiple sets of chromosomes).

Researchers from Leibniz Institute for Age Research — Fritz Lipmann Institute (Jena, Germany) now identified a crucial role of telomeres, the end structures of chromosomes, for sensing cells with a wrong chromosome number, referred to as aneuploidy.

For more than 100 years, researchers have been unable to explain why cancer cells contain abnormal numbers of chromosomes, a phenomenon known as aneuploidy.

Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg, in collaboration with colleagues from the US Institute for Systems Biology (ISB) in Seattle, have now systematically studied the genetics of this process, which biologists refer to as aneuploidy.

I'm studying how changes in chromosome number (a condition known as aneuploidy) affect cell physiology and cancer progression.

PGS for gay couples helps determine if any of the embryos have extra or missing chromosomes, known as aneuploidy, or if any chromosomes have translocated, which means a piece of a chromosome has broken off and reattached itself to a different part of the chromosome or even to another chromosome.

Not exact matches

People with aneuploidy may exhibit clusters of symptoms referred to as syndromes.

Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.

PFC offers CCS as an option for patients undergoing in vitro fertilization (IVF), as a treatment for recurrent miscarriage, prevention of aneuploidy in pregnancy, and for women that wish to improve implantation rates, reduce miscarriage rates, and reduce the risk of multiple pregnancy after IVF.

It is here that he has refined his theory of aneuploidy as the cause of cancer.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

Elledge argues that simply losing or gaining one copy of a gene through aneuploidy can influence tumor growth as well.

Aneuploidy is known to be deleterious and underlies several common human diseases, including cancer and genetic disorders such as trisomy 21 in Down's syndrome.

In contrast to the view that aneuploidy is deleterious, the aneuploid unisexually generated isolates MN35 (n +113) and MN55 (n +19) were as virulent as the euploid wild - type parent, despite their modest TS growth at 37 °C on YPD rich media in vitro (Figure 7).

Aneuploidy is responsible for the observed phenotypic changes, as chromosome loss restoring euploidy results in a wild - type phenotype.

Phenotypic diversity is caused by this aneuploidy, as loss of the aneuploid chromosomes restored both euploidy and the wild - type parental phenotype.

The efficient compaction of DNA during cellular division ensures equal distribution of DNA into daughter cells and prevents aneuploidy, which has been implicated as a major driver of tumor development.

This study enabled us to propose mitotic defects, aneuploidy and consequent cell death as a new etiology of Human Primary Recessive Microcephaly (MCPH).

Aneuploidy is associated with a variety of diseases such as cancer and microcephaly.

We demonstrated that aneuploidy can function as a novel source of genomic instability, as aneuploid cells tend to display elevated levels of mutation, mitotic recombination, and chromosome loss.

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in vitro - cultivated strains are highly aneuploid, with interstrain diversity and intrastrain mosaicism.

The method provides quantitative aneuploidy calls, and is integrated into an R software package available on GitHub and as an Additional file of this manuscript.

Aneuploidies frequently affect only a subset of cells in a sample; this is known as «mosaic» aneuploidy.

Quote from the abstract,» This is an interesting observation as it is assumed that aneuploidy is a key event in cancer induction and at present no other aneugenic plant - derived substances of dietary relevance are known.»

Aneuploidy scans are not routinely performed, as many normal pregnancies may have some of these features - ie there is a high false - positive rate.