Sentences with phrase «as angiogenesis»

However, the exact cytoskeletal strategy that the cell uses to cross the physical BM barrier depends on the physiological context and the physical environment, as observed by examining actin structures in invading cancer and immune cells, and in cells that invade during developmental processes such as angiogenesis and anchor cell invasion in Caenorhabditis elegans.

The formation of new blood vessels from existing vessels, known as angiogenesis, depends on a sequential process that involves endothelial cells (EC) and pericytes1.

A fragment of one of the proteins that cancer cells use to exert the clotting effect, called TFPI2, could be used to antagonize blood clotting  therapeutically, they write in Cancer Research. The findings could also have implications for understanding the effects of current medications, such as the angiogenesis inhibitor bevacizumab, also known as Avastin.

One goal of drug designers has been to prevent tumors from making new blood vessels, a process known as angiogenesis.

This cancer is characterized by the growth of new blood vessels, known as angiogenesis.

«What's more, the cancer - related proteins were using first neighbours to interact with the pathways controlling important processes for carcinogenesis, such as angiogenesis, autophagy and DNA repair.

Not exact matches

Since 2002, he has served as professor of vascular physiology at Maastricht University and professor of angiogenesis in tissue engineering at the Technical University Eindhoven.

Before his death, Folkman began to explore treatments with angiogenesis inhibitors for conditions as seemingly disparate as myocardial infarction, diabetes, macular degeneration, and even obesity [4].

The cannabinoids inhibited the expression of several genes critical to angiogenesis known as the VEGF (vascular endothelial growth factor) pathway.

Trebananib (formally known as AMG 386; Amgen) is a first - in - class peptide - Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

He then carried out his doctoral research on cancer angiogenesis at the University of Nottingham, followed by an appointment in the Laboratory for Experimental Cartilage Research, initially as postdoc and then as a group head.

Researchers found that histatin - 1 promotes angiogenesis, as well as cell adhesion and migration.

«Obesity - associated metabolic perturbations are emerging as major drivers of obesity - related cancer, including alterations in growth factor signaling, inflammation, and angiogenesis,» explained Dr. Hursting.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

They focused towards this end on the vascular growth factor Angiopoietin - 2, which is produced by endothelial cells and does not just control angiogenesis, but acts as a key responsiveness factor for endothelial cells.

«Its involvement in the recruitment of inflammatory lymphocytes and promotion of angiogenesis may serve as a critical link between colitis and CAC.

The RAPS has been shown to be involved in the pathogenesis of various vascular abnormalities such as inflammation and pathological angiogenesis.

Peter Carmeliet: «Our discovery opens up a whole new domain for inhibition of angiogenesis in various diseases such as cancer.

Through the UCSD Clinical Cardiovascular Cell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pain.

His research interests focus on understanding basic underlying mechanisms of ocular angiogenesis and identifying therapeutic approaches to treating neovascular eye diseases such as macular degeneration and diabetic retinopathy.

As an active researcher, much of her work is focused on regulation of angiogenesis in pediatric solid tumors, including Wilms» tumor, neuroblastoma, and hepatoblastoma.

BM - MSCs demonstrate broad therapeutic potential, as seen by their angiogenesis - promoting capacities and their immunomodulatory properties.

Furthermore, we will expand on studies related to the regulation of vascular homeostasis, as well as related to the regulation of inflammation by angiogenesis.

One of the early pioneers of angiogenesis research, Dr. Konerding leads a group focusing on angiogenesis in inflammation, wound healing, and tumor growth, as well as on clinical anatomy.

Given this, these molecules show promising therapeutic potential not only for AMD, but also for other major conditions that involve angiogenesis and inflammation, such as cardiovascular disease and cancer.

(i) In this context we have demonstrated the angiogenesis - modulatory actions of components of the innate immunity, such as neutrophil - derived alpha - defensins, or the complement system and in particular, the anaphylatoxin C5a receptor.

The CAM and zebrafish in vivo assays and the ex vivo mouse aortic ring assay clearly identify kahweol as a new anti-angiogenic compound, but gives no information on which specific steps of angiogenesis are targeted by this compound.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

As we have previously suggested, since tumor angiogenesis is very complex and involves a number of different cell types, a multi-target approach for the anti-angiogenic treatment of cancer could be expected to produce better results [18].

Although 50 nmol of kahweol per CAM was required to observe in vivo inhibition of angiogenesis in 100 % of treated eggs, as little as 10 nmol of kahweol was enough to induce clear inhibition of angiogenesis in 25 % of the tested eggs in the CAM assay.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Hence, angiogenesis - associated proteins might serve as potential targets for this type of tonsillar and base of tongue cancer.

This finding, made by two scientists from TSRI, may lead to new therapies, as abnormal angiogenesis is the leading cause of vision loss in the United States.

VEGF is required for angiogenesis and inhibitors, such as bevacizumab, show some therapeutic potential with increased disease - free survival.

Dr. Folkman's 1971 original hypothesis that solid tumors are angiogenesis - dependent initiated studies in tumor biology that extended to disciplines as diverse as ophthalmology, cardiology, dermatology and tissue engineering.

For example, proteins related to angiogenesis, the process through which new blood vessels form to ensure supply of oxygen and nutrients to a tissue such as a tumor, are found to be clearly associated to clinical outcome in HPV - positive samples.

In July 2002, Dr. Post returned to the Netherlands as a Professor of Vascular Physiology at Maastricht University and Professor of Angiogenesis in Tissue Engineering at the Technical University Eindhoven.

The authors are planning future studies exploring methods for efficient retinal delivery of Ro5 - 3335 and the relationship between RUNX1 and VEGF, as both factors play a role in angiogenesis.

The data presented in this article suggests that tumor subtype needs to be taken into account during treatment design as blocking angiogenesis and therefore increasing tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risAs we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

Also, a 2012 study published on the Medical Journal 3 Biotech shows that the anti-cancer compounds in mushrooms play a crucial role as a reactive oxygen species inducer, mitotic kinase inhibitor, antimitotic, angiogenesis inhibitor, topoisomerase inhibitor all leading to apoptosis (cell death) and eventually checking cancer cell proliferation (4).