Sentences with phrase «as antigen for»

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

To suggest that anti-particles are a reference for black hole physics is a redundancy based upon antigens wavering abilities in quantum physicality's unknowable as a phonon of excitabilities fantasia.

This usually involves specific stool tests for the Cryptosporidium parasite, such as the Cryptosporidium antigen test, which your pediatrician can order.

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

The company wanted to use it as a diagnostic marker for disease: If synthetic versions of antibodies could be tagged with aequorin in the lab, then whenever they matched up with an antigen (or surface protein) of a specific pathogen in blood or tissue, the sample would glow.

In the case of foreign antigens, for example components of viruses or bacteria, this is useful, as they can then be eliminated from the tissue.

«The antigens must get far enough into the cell for them to be processed, but must also return — as antigen fragments — to the surface.»

«We put antigens (substance that triggers the production of antibodies) specifically synthesized to catch antibodies for each of the diseases, their interaction functions as a lock and key mechanism.

Cancer cells may contain mutations in genes that code for antigens, producing misshapen or otherwise altered antigens that are known to scientists as neoantigens.

«The retraction states that Mignot and his colleagues were unable to replicate the results of the ELISpot assay, a widely used method for measuring how immune system cells such as T cells respond to fragments of foreign proteins, called antigens,» Underwood writes.

The scientists» genomic search narrowed in on genes that code for the production of antigens, which serve as a source of identification to the immune system.

Nirbhay Kumar, a molecular biologist at the Johns Hopkins School of Public Health in Baltimore, wondered whether injecting the genes for the Plasmodium antigens would work as a vaccine.

As for the 20 per cent reduction in carcinoembryonic antigens, it isn't clear whether this is likely to affect an otherwise healthy person's chances of developing cancer.

It's hoped this latest insight will lead to the widespread use of antigen - specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves» disease and systemic lupus erythematosus (SLE).

Her dissertation looked at whether variants in the PSA gene — that is, the gene that codes for the PSA (prostate specific antigen) protein doctors use as a screen for the existence or recurrence of prostate cancer — had any influence on developing the cancer.

They immunized them with the antigen α - fetoprotein, which is found in 70 - 80 percent of human liver cancers, and serves as both a biomarker for diagnosing and a target for treating the sixth most common cancer worldwide, He says.

The scientists took the genes for the most effective liver cancer antigen receptors on those T cells, put those receptors on human T cells and the resulting engineered human T cells eradicated the cancer as well, without hurting normal liver cells, they report in the journal Hepatology.

By developing blood biomarkers and «immunologic signatures» related to antigen - specific T - cell responses, the researchers hope to identify individuals with latent TB infection who are at greatest risk for progression to active disease, allowing development of prevention strategies to target those at highest risk in areas with high rates of infection (usually low - and middle - income countries), as well as high income countries such as the U.S., where factors such as recent infection and HIV co-infection are associated with an increased risk of progression to active TB.

Cornell and Ludwig Institute for Cancer Research scientists have developed a way to produce a protein antigen that may be useful as vaccine for schistosomiasis — a parasitic disease that infects millions of people, mostly in tropical and subtropical climates — according to new research in the journal Protein Expression and Purification, June 2017.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

In people with type 1 diabetes, however, the training goes wrong and insulin is mistaken for a foreign antigen, such as a virus, that needs to be eradicated.

«For example, despite matching the ABO blood group antigens during red blood cell (RBC) transfusion, up to 45 percent of chronically transfused patients, such as those with sickle cell disease or thalassemia, develop antibodies to mismatched minor antigens on transfused RBCs; this process is known as alloimmunization.»

Ira Mellman and Ari Helenius discover endosomes, which soon emerge as key sites for antigen processing and peptide loading to MHC class II molecules.

Most genes known to be associated with type 1 diabetes — including those currently considered the top two high - risk genes, which are the ones TEDDY screens for — are classified as human leukocyte antigen, or HLA genes.

Therefore adjuvant research activities will aim to develop stable formulations (and combinations thereof) for the focused and rational improvement of specific aspects of the immune response, as required in light of the unformulated antigen's in vivo immunoprofile.

The rational use of adjuvants will be studied in detail, as very often researchers use a «shotgun» approach with adjuvants, testing entire panels with their antigens in the search for improved immune responses.

Diagnosis of BPDCN was confirmed by the positivity of the cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid dendritic cells (such as CD123), and the negativity of the cells for lymphoid, NK and myeloid lineage - associated antigens.

As an example, we designed the following question for querying the ontology: «What Brucella virulence factors are also protective antigens?»

NY - ESO - 1 has served as a model antigen for our laboratory and clinical research.

Finally, cancer cells may naturally stop displaying antigens on their surface, as part of their strategy for evading an immune response.

To achieve this, the immune system is always on the lookout for evidence of foreign stuff, or what scientists refer to as antigens.

Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation.

Currently, pDNA can be used directly as a therapeutic agent (e.g., in gene therapy or generation of vaccine antigens) and indirectly for a range of applications.

«Paradoxically, the study does offer some good news for those working on live vaccines or live vaccine vectors because these are not just vaccine antigens but organisms in their own right that necessarily manipulate host responses (such as those involving IL28B) for their own survival.

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

For the detection of specific antigens, the following primary antibodies were used: mouse monoclonal anti-Tuj1 (Covance, Princeton, NJ, USA) as a neuronal marker, rabbit anti-L1 (kindly provided from Dr. Asou)[52] and rat monoclonal anti-L1 (Millipore, Billerica, MA, USA) as granule cell markers, rabbit anti-calbindin D28K (Millipore) as a Purkinje cell marker, and rabbit anti-glial fibrillary acidic protein (GFAP, DAKO, Denmark) as an astrocyte marker.

His ongoing research projects include programs to develop adjuvants for use with H5N1 pandemic influenza antigens as well as West Nile Virus vaccines.

Although much is known regarding the specificity and efficacy of antibody responses, our knowledge of the function, phenotype, and specificity of the antigen - specific B cells that are responsible for antibody production, as well as for long - term humoral memory, is inadequate.

Importantly, we show an absence of anti-OspA responses and that antibody levels to distinct antigens can drop significantly in untreated animals (as for IP67 and IL75) and remain elevated in treated animals (as for IK66 and IH22).

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

The department has developed and produced 15 different formulations for early clinical trials (e.g. vaccine antigens produced by heterologous expression) and has conducted more than 20 clinical trials as sponsor.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.

For all cell lines, we observed a gradient of expression of the two antigens in the cell population (Figure 1a), as we reported previously, and confirmed in an independent analysis of the secretome of human ES cells [16].

The exclusive, worldwide license, announced Sept. 14 by Mustang Bio, will allow a new type of CAR (chimeric antigen receptor) T - cell therapy to be tested in a clinical trial as a treatment for B - cell non-Hodgkin lymphomas.

Capacity for substantial genetic payload supports multiple tumor antigens or a combination of tumor antigens and other immune stimulatory molecules, such as checkpoint inhibitors.

An interrelationship exists between viral - vector upstream and downstream bioprocessing strategies and those for other therapeutic platforms such as chimeric antigen receptor (CAR) T cells and induced pluripotent stem cells (iPSCs).

The small intestine uniquely functions as a digestive / absorptive organ for nutrients as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules.

FEMS Immunology & Medical Microbiology 43, no. 2 (2005): 213 - 222; Santelmann, H., et al. «Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome.»

GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation of luminal antigens, or sometimes provoking damage to the intestinal mucosa, such as in coeliac disease or food allergy.

For instance, a decrease in bifidobacteria populations leads to intestinal hyper - permeability, or leaky gut, which in turn leads to the translocation of metabolic byproducts, food antigens, bacteria, and lipopolysaccharide (also known as LPS, an immunogenic cell wall component from Gram - negative bacteria) across the gut barrier into systemic circulation (Rapin & Wiernsperger, 2010).