The technique involves replacing a mutated copy of the gene with a healthy copy in stem cells isolated from the patient, which are then transfused back into the body — a process known
as autologous stem cell transplantation.
Not exact matches
«If we win, the entire regulatory structure for
autologous cell processing, with or without culture, will be rewritten such that any physician using good practices and treating patients responsibly can use
stem cells as part of his or her medical practice,» he says.
Autologous hematopoietic
stem cell transplantation (AHSCT) has been investigated
as a treatment for aggressive MS, the rationale for which is immune reconstitution.
Plerixafor has been approved by the FDA
as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic
stem cells to the bloodstream for collection and subsequent
autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
The treatments typically use
autologous stem cells (those obtained from one's body) to treat everything from bad knees to incurable disease such
as ALS or Parkinson's.
Embryonic
cell lines and
autologous embryonic
stem cells generated through therapeutic cloning have also been proposed
as promising candidates for future therapies.
Biological markers of Mesenchymal Stromal
Cells as Predictors of response to
Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study.
As Dr. Maharaj explained, «One last option for Gale was high dose chemotherapy followed by an
autologous bone marrow
stem cell transplant.
The US Food and Drug Administration (FDA) has granted Priority Review designation for tisagenlecleucel (Kymriah), formerly known
as CTL019, for treatment of adult patients with relapsed or refractory diffuse large B -
cell lymphoma (DLBCL) who are ineligible for, or have relapsed after,
autologous stem cell transplant.
Review of «Biological markers of Mesenchymal Stromal
Cells as Predictors of response to
Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study» from
Stem Cells by Stuart P. Atkinson
Thus, for the specific example you gave of using
autologous bone marrow
stem cells injected into the brain, this scenario would indeed require full FDA approval
as it does not meet the criteria of homologous use,
as you said.
Natesan S, Wrice NL, Baer DG, et al., Debrided Skin
as a Source of
Autologous Stem Cells for Wound Repair.
The really important questions are whether this therapy can be given safely; early in the disease course; and
as second - line treatment, replacing an
autologous stem cell transplant.
Their research focused on evaluating the safety and efficacy of
autologous bone marrow - derived
stem cell transplantation in individuals with type 2 diabetes with good glycemic control
as well, which emerged
as an important aspect in the transplantation group
as well
as in the non-transplanted group.
Additionally, non-interventional treatments such
as Autologous Conditioned Plasma (ACP),
stem cell therapy, and rehabilitation / conditioning are proven treatment modalities that are coupled with surgical intervention or used alone
as primary treatment.