Sentences with phrase «as biomarkers»

Lin28 may serve as a biomarker for such treatment - resistant tumors.»

«Sperm RNA may serve as biomarkers of future health, researchers find.»

Bone marrow aspiration being somehow invasive, we then investigated whether the detection of circulating tumor cells (CTC) in the blood could be used as a biomarker of early tumor relapse or progression.

Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.

The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants.

Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety - related responses

Through regional networks in the U.S. like the Pediatric Neuromuscular Clinical Research (PNCR) Network and Project Cure, and international organizations such as the International Coordinating Committee (ICC) and TREAT - NMD, the SMA community has collaborated effectively on recruiting patients, establishing standards of care, standardizing outcome measures, and supporting multi-site clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History studies.

Gross cystic disease fluid protein - 15 / prolactin - inducible protein as a biomarker for keratoconus disease.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

Strong infrared rays from an extrasolar planet is considered as a biomarker of plants.

An international team led by Simona Cristescu from Radboud University found that ethylene is produced during inflammation and quickly released in exhaled breath as a biomarker of bacterial infection, thus having important clinical implications.

We propose that it is now feasible to validate the dimers as biomarkers for this disease,» says Carulla.

«This way,» he says, «we can start to evaluate the use of various compounds as biomarkers and indicators of patient recovery.»

During my medical training I had the opportunity to collaborate in a study on RNA as a biomarker of prognosis.

These genes could be very useful as biomarkers for monitoring PCB bioremediation.»

He is currently pursuing the possibility to use circulating microRNAs as biomarkers as well as therapeutic targets for neurodegenerative diseases including Alzheimer's disease (AD).

Today, we're excited to report that researchers in the UK have identified a substance in the blood that shows promise as a biomarker for HD.

«While HPV - specific serum and salivary antibody testing has been evaluated, HPV cfDNA has not been well studied as a biomarker to characterize metastatic or advanced oropharyngeal cancer causally related to HPV,» said Dr. Hanna.

Its expression could be used as a biomarker test to ensure patients might benefit from an NPTX2 inhibitor, when one is developed.

A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets.

With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer.

«But if further studies confirm and extend what we have found, we may use the skin biopsy as a biomarker for disease severity.

There is significant potential for exosomes as biomarkers and treatment targets of various cancers as we learn more about them,» says Mattias Belting.

In the future, doctors could thus use Gab2 as a biomarker and infer the course of the disease by measuring Gab2 levels.

The team is also working to identify signatures of MMPs that could be exploited as biomarkers for other types of cancer, as well as for tumors that have metastasized.

«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.

According to the researchers, these miRNA sequences were found to be present in much higher levels in patients with HD (some were undetectable in the brain cells of normal patients), which would also make them excellent targets as biomarkers for HD expression.

Their pursuit of Id4 as a biomarker for patients with GBM continues in hopes of making useful predictions of tumor invasion and survival.

The scale cortisol content was biologically validated as biomarker for chronic stress as it provided a retrospective record of the stress response.

The technique of using sodium ions in the body as a biomarker for imaging is very challenging because of the lower detectability of the sodium signal in biological tissue by currently available MRI scanners.

The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.

«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.

Using a simple genetic test, doctors could one day use CHL1 as a biomarker to determine whether or not to prescribe SSRIs.

During the webinar, our expert panel of researchers will discuss: • Strategies and technologies for successful cancer biomarker discovery through robust detection and analysis of miRNAs in biofluids • Research into analytic and biological variables that impact miRNA measurements in serum and plasma from the clinical pathologist's point of view • The novel application of miRNAs in serum as biomarkers of aging and chronic disease • The answers to questions submitted by the live, online viewers.

Their natural characteristics make them uniquely suited for research and clinical applications, including as biomarkers both for diseases and for intrinsic biological activity.

The high MAO - B activity consistently observed in patients with Parkinson's disease has been proposed as a biomarker, but there has been a lack of suitable small molecule probes for MAO - B specific detection in live cells and tissues.

The authors say these results suggest that MAO could be helpful as a biomarker to someday diagnose and monitor the disease in patients, possibly using body fluids.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

«The findings advance our understanding of the role of lncRNAs in cancer biology and, importantly, broaden the opportunity to use lncRNAs as biomarkers to detect prostate cancer.»