Sentences with phrase «as biomarkers in»
The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.
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Furthermore, PRL - 3 has the potential to be used as a biomarker in personalised therapy for AML patients.
«This work led by Professor O'Donnell is a technical tour de force, providing a wonderful resource for other biomedical researchers,» said Mike Murphy, Ph.D., programme leader, Mitochondrial Biology Unit at Cambridge University, U.K. «A particularly important aspect is the focus on platelets, which are readily available from patients» blood in diagnosis, prognosis or as a biomarker in assessing therapies.
Salivary cortisol as a biomarker in stress research.
Title: Phosphorylated heavy chain neurofilament as a biomarker in dogs with intervertebral disc herniation
Research Interests Critical care of polytrauma patients, troponin as a biomarker in traumatic myocarditis, the application of Continuous Renal Replacement Therapy (dialysis) for companion animals with acute kidney failure, advanced therapeutic approaches to immune mediated hemolytic anemia, and novel laboratory assessment of coagulopathies (including thromboelastography and platelet aggregometry).
This e-book is based on a critical evaluation of existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings.
The aim of this book was to evaluate the usefulness of salivary cortisol as a biomarker in various settings.
Salivary cortisol as a biomarker in stress research.
Not exact matches
There are numerous services he says Linear could be selling to overseas clients such as lab tests, assays, particular medical compounding or a process that looks for a biomarker, a signal in the blood that shows whether a certain drug being trialled is working or not.
In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.
Objective To determine the types and frequency of rice and rice - containing products consumed by infants in the first year of life and the association with As biomarker concentrations.
While we are unaware of any prior studies relating As biomarker concentrations to rice intake among infants, associations have been observed in pregnant women in our cohort, 19 children in the National Health and Nutrition Examination Survey, 16,18 and multiple studies of adults.11 - 15
Intake of rice early in childhood has not been well characterized in the United States, and there are only limited data from other regions of the world.5, 6 Moreover, biomarker concentrations of As among infants consuming rice are virtually unknown.
In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.
«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.
He is concerned that when biomarkers are used, other factors are ignored, such as what is happening in a person's life.
The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.
Recent advances in detection, as well as the comprehensive power of clusters of biomarkers, or biomarker signatures, are making the brain more accessible and neurological diseases more treatable.
In the process, they might identify a planet's surface features — such as oceans, continents, ice caps and even cloudbanks — and detect the presence of biomarkers like oxygen, methane and water.
Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional human proteins (over 20,000 on a single array) to test the antibodies present in human liquid biopsy samples, such as blood, serum, plasma, CSF, or tissue lysates.
«We can see a single femtogram per mL of a biomarker, which is sensitive enough to detect biomarkers in saliva and breath condensate as well.»
«These biomarkers are not as resilient as once thought and they may provide a future window into determining how much, and how quickly, these oil components may linger in the environment when exposed to air, sunlight, and the elements.»
«In detail, the subglandular ADC was inversely correlated to the time interval between MRI and delivery and therefore emerged as a powerful imaging biomarker in evaluating patients with impending delivery.&raquIn detail, the subglandular ADC was inversely correlated to the time interval between MRI and delivery and therefore emerged as a powerful imaging biomarker in evaluating patients with impending delivery.&raquin evaluating patients with impending delivery.»
«Targeting multiple biomarkers could potentially allow us to identify prostate cancer at its early stages as well as after metastasis in one scan.»
As Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druAs Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druas a reliable biomarker in personalised medicine to select the best suited candidates to receive this drug.
This new study of non-military, civilian trauma patients visiting the emergency department builds on recent research conducted by Dr. Samadani, supported through the Cohen Veterans Center, which found that the use of this novel eye - tracking technology could reveal edema, or swelling, in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.
«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»
«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»
In the future, doctors could thus use Gab2 as a biomarker and infer the course of the disease by measuring Gab2 levels.
As not all cases of Barrett esophagus become malignant, it is important for the treating physician to know whether there are reliable indicators (so - called biomarkers) which allow the estimation of a tumor development in the still benign tissue.
Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.
As promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectivenesAs promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectivenesas those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectiveness.
The single molecule array (Simoa) technology developed by Quanterix, and the fully automated HD - 1 analyzer, offers unprecedented improvement in sensitivity proteins over current technologies for the detection of blood - based biomarkers — as much as 1000 times more sensitive than conventional immunoassays.
In the end, the identification of microbial species or metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptomIn the end, the identification of microbial species or metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptomin Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptoms.
The new design of immunosensor exhibits high sensitivity, selectivity and rapidity as the detection of NS1 biomarker can be done in less than 1 hour.
The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.
First, he points out that patients with MDD exhibit illness behavior such as loss of energy, and that inflammatory biomarkers in MDD also suggest an illness - related origin.
The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.
This year the findings are published in Cancer Epidemiology, Biomarkers & Prevention as well as in a standalone consumer publication Cancer Prevention & Early Detection Facts & Figures.
Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.
The next steps are to implement sequencing - based biomarker assays, such as reported in our study, in accredited pathology laboratories.
«In addition to the potential of these genes and gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.
A total of 67 biochemical features discriminated cancer from benign tumors in these samples, but only four specific metabolites could be considered as biomarkers for cancer: creatinine riboside, tryptophan, Nε, Nε, Nε - trimethyllysine, and 3 - methylhistidine.
«Using a biomarker of heavy alcohol consumption such as PEth along with self - reporting could provide an objective measure for use in research, screening and treatment of hazardous alcohol use among young adults,» she said.
«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.
«Our results, and methods, could have implications for the analysis of endogenous and exogeneous compounds in the exhaled breath as biomarkers of systemic and lung diseases, as well as in development of new approaches to study human exposure to airborne contamination.»
The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy.
As well as being of value in diagnosis and in assessing treatment, validated biomarkers could help to remove the stigma surrounding mental healtAs well as being of value in diagnosis and in assessing treatment, validated biomarkers could help to remove the stigma surrounding mental healtas being of value in diagnosis and in assessing treatment, validated biomarkers could help to remove the stigma surrounding mental health.
Plasma levels of this biomarker rose with kidney deterioration in patients with MMA, and may serve as a valuable indicator of MMA kidney disease progression in the clinic.