Sentences with phrase «as cancer drivers»
«Once identified, we further tested their role as cancer drivers, for example by looking at molecules with and without mutations and comparing their structure and function,» he adds.
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I ask, still stuck on heritage as my cancer driver and the reason I'm in this room to begin with.
Not exact matches
Choking back tears, he noted that his father worked two jobs, one as a school bus driver and one in the factory linked to the pollution, to support his family before succumbing to cancer.
«These changes are often referred to as tumor drivers but these are not the only deviations that impact cancer growth.
«We'd like to extend this further to examine for driver genes in other types of lung cancer, such as squamous cell lung cancer.»
The larger scale Cancer Genome Atlas study provided the information needed to alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.
Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.
The expected outcome, if MYC was the sole driver of the cancer, was tumor growth on the MYC line as well as the paired line.
«Obesity - associated metabolic perturbations are emerging as major drivers of obesity - related cancer, including alterations in growth factor signaling, inflammation, and angiogenesis,» explained Dr. Hursting.
Maggie Blanks, CEO of the Pancreatic Cancer Research Fund, said: «Professor Magee's findings add further weight to a growing body of evidence which points to Hedgehog signalling as an important driver of pancreatic cCancer Research Fund, said: «Professor Magee's findings add further weight to a growing body of evidence which points to Hedgehog signalling as an important driver of pancreatic cancercancer.
Interpretation of genome sequencing data is a significant challenge because of the volume of genomic data to sift through, as well as the large, growing body of research on molecular drivers of cancer and potential targeted therapies.
In 2007, he joined Columbia University as a post-doc, where he developed network - based computational approaches aimed at identifying key drivers of initiation and progression of cancer, as well as mechanisms of therapeutic response and drug resistance.
As the first step in a next generation knowledge system for cancer, the GDC enables and accelerates efforts to identify both high - and low - frequency cancer driver mutations, assists in revealing the genetic determinants of response to therapy, and informs the composition of clinical trial cohorts.
My team is investigating the utility of Jak inhibitors to target colorectal tumours and the role of DCLK1 as a driver of gastric cancer.
«The RapidCaP system has revealed a specific role for Myc as a druggable driver of metastasis in prostate cancer,» says Trotman.
«RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten - mutant metastasis» appears online in Cancer Discovery on January 21,cancer reveals Myc as a driver of Pten - mutant metastasis» appears online in Cancer Discovery on January 21,Cancer Discovery on January 21, 2014.
In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responses.
Most breast cancers contain subclonal populations, many of which harbor driver alterations, and subclonal structure is typically remodeled over time, across metastasis and as a consequence of treatment interventions.
Five hundred cancer patients are getting an in - depth look at their genomes as part of a new clinical study that is revealing some of the key molecular drivers of metastatic cancers.
Metabolic reprograming is now recognized as a fundamental driver of cancer and a detailed understanding of the metabolic rewiring that occurs in TNBC will undoubtedly reveal novel target opportunities.
This «study» invokes IGF - 1 as the driver behind the cancer outcomes.
He is entering as part of a very competitive team, all members of the British Racing Drivers» Club at Silverstone, running for the CLIC Sargent children's cancer charity.
«Mammalian retrobiome as a driver of evolution, cancer and aging,» presented by Dr. Andrei Gudkov, Senior Vice President of Basic Science and The Garman Family Chair in Cell Stress Biology, Roswell Park Cancer Instcancer and aging,» presented by Dr. Andrei Gudkov, Senior Vice President of Basic Science and The Garman Family Chair in Cell Stress Biology, Roswell Park Cancer InstCancer Institute.
Amidst a great fanfare of recognition and hope, the rise of Immunotherapy as the key driver for making a significant impact on the treatment of cancer has seen oncology become the primary area of concern in the Life Sciences sector.