Sentences with phrase «as cell adhesion»

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

In fact, the researchers found gene expression differences between ASD and non-ASD in genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cycle.

Researchers found that histatin - 1 promotes angiogenesis, as well as cell adhesion and migration.

Not exact matches

The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter protein set and the process of learning as well as between a cell adhesion set and the process of memory storage.

Shenoy and his colleagues were interested in the points where cells actually bond to the surrounding matrix, known as focal adhesions.

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

Cells can fail to stick together sufficiently, referred to as reduced cell adhesion, or they can stick together normally but not respond in the correct way to that contact, referred to as a loss of contact inhibition.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling, cell adhesion and cytoskeleton dynamics required for tumor invasion.

However, because IFN - γ is widely known to influence several endothelial properties, such as junctional integrity (21) and adhesion molecule expression (22), we elected to remove this cytokine from cultures immediately after the second session of cell selection.

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

This work outlines how a receptor termed LFA - 1 on the surface of T - cells mediates adhesion to other cells such as cancer cells.

Furthermore, Eph signalling in mural cells has been shown to control cell motility and adhesion as well as pericyte - EC assembly33, 34.

The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

As the distance from the substrate bottom increases, adhesion aggregates become smaller and almost undetectable in some cell lines.

The Lauffenburger research group focuses on elucidating important aspects of receptor - mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death.

We examined the effect of loss of the gene on bacterial motility, adhesion and invasion of tissue culture cells and chicken colonisation, as well as the effect on the muropeptide profile of the peptidoglycan sacculus.

As described below, however, the LPA / LPA2 axis appears to affect T cell adhesion on the surfaces coated with LFA -1-ligand or fibronectin.

The release of inflammatory cytokines, or intercellular signaling molecules such as interleukin - 1 (IL - 1), interleukin - 2 (IL - 6), and tumor necrosis factor alpha (TNF - α) at the site of immune activation causes other immune cells migrating throughout the lymphatic vessels of the body to express more cell adhesion molecules (CAMs).