Sentences with phrase «as cell fate»

Cells are only transiently pluripotent as cell fate specification signals initiate differentiation soon after the formation of pluripotent blastomeres.

Not exact matches

The event will be headlined by a world title match between Triple H and Roman Reigns, as well as a Hell in a Cell match between Undertaker and Shane McMahon, with the fate of WWE hanging in the balance.

The molecules help determine the fate of developing immune cells known as T cells.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

Around 2000, then - postdoc Wagers and other researchers in Irving Weissman's and Thomas Rando's labs at Stanford revived the method, known as parabiosis, to study the fate of blood stem cells and muscle cells.

By studying what pushes those 6 percent into their fate as photoreceptor cells, researchers might figure out how to generate a larger number of transplantable cells.

Nishimura suspected that genotoxic stressors, such as radiation or harsh chemicals, might play a role in the stem cells» fate, because they've been implicated in other signs of aging.

«It was once believed that effector and memory cells arose as two distinct populations, with some cells initially fated to be effector type and some to be memory,» McDonald said.

Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins.

Now known as a blastocyst, the embryo undergoes a dramatic division of cell fate, forming a distinct outer layer of cells and an equally distinct bulge of about 20 or 30 cells on the inside.

The images depict what might be called embryology in flagrante: micrographs of sperm cells, trailing accordion - like pleats of white zags as they streak across a vast blue ocean of ooplasm; a multihued blastocyst in the process of hatching out of the egg's zona pellucida; and egg cells with a fringe of glowing, fate - determining proteins, looking a bit like a solar eclipse inside a cell.

«Sniffing out stem cell fates in the nose: Using single - cell RNA sequencing and clever statistical analysis to track stem cells as they mature.»

An asymmetric cell division in non-stem cells can instead result in two daughter cells with very different fates, such as one large cell that reinitiates cell division prematurely and a much smaller cell that either grows very slowly or dies.

The genetic and environmental cues that determine the cell's fate can be thought of as inputs, with the cell itself as the processor, Dunn says.

The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etCell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

FATE MAPPING WITH CRISPR: Thanks to a new tool called GESTALT, researchers can now introduce a 300 - base - pair lineage barcode into cells and, using the CRISPR - Cas9 system, allow edits to accumulate as those cells divide.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Human as well as mouse preimplantation embryos are studied to investigate the mechanisms that regulate cell - fate, growth and differentiation.

Although Wnts were better known because of their role as morphogens — proteins that pattern bodily structures and determine cell fates — Zou recently showed how members of the Wnt family served to guide pathfinding axons up and down the spinal cord by attracting or repelling receptors on the growth cones of sensory or motor nerves.

We also discovered that this nuclease activity varies greatly depending on the cell type.Until now, the fate of exogenous DNA introduced into a cell was treated as a black box.

ieCPCs avoid this problem as they are already locked into their fate of becoming heart cells.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

The authors refer to their hypothesis as differential partitioning - environmental buffering, and suggest that partitioning cells into different fates according to prevailing conditions could be a strategy used by many other types of cell coalitions — whether microbial communities, humans, trees, or jellyfish.

We differentiated our iPS cells as embryoid bodies (EB)(Figure 4A) in the presence of FBS to induce endodermal and mesodermal fates, and in the presence of retinoic acid to induce an ectodermal fate, and after ten days allowed them to adhere to tissue culture dishes.

The computer - managed microscope then follows the fate of each cell over an extended period of time, returning to the same neuron over weeks or months to take pictures of them as they grow.

Understanding the conditions that cause these cells to go off to different fates may have a bearing on health problems such as ectopic pregnancy, which occurs when the embryo develops outside of the womb in about 1 of 60 pregnancies, or molar pregnancy, which is abnormal tissue growth within the uterus that affects about 1 in every 1,000 pregnancies.

By delicately labeling stem cells in the brains of live mice and recording the fates of their offspring, Obernier discovered that the cells don't divide in a self - renewing fashion, as the field had predicted.

The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

It is involved in the establishment of cell asymmetry, is particularly evident in large cells, such as eggs and neurons, and has key roles in cell fate decisions, cell migration, cell morphology, and polarised cell functions.

Suzuki, possibly inspired by his new job as a research scientist at the Research Unit for Organ Regeneration in Kobe, Japan, explains it this way: «Just as humans can start over in life, differentiated cells can also take on other fates following the generation of undifferentiated stem cells.»

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

We are studying the mechanisms that maintain multipotent cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.

Lineage commitment in the mammalian embryo is most often depicted as a series of binary choices between alternate cell states, and increasing evidence supports the hypothesis that fate decisions in embryonic stem (ES) cell cultures reflect these developmental processes [1].

miRNAs function as important regulatory switches, influencing cell fate decisions and tumor development.

A final note on the fate of amino acids - once absorbed, amino acids can be used directly by cells for the synthesis of new enzymes or new cell structures, for the building of structural proteins (such as actin and myosin in the muscles), for the synthesis of OTHER amino acids (via transamination), or used for energy.

He has a seeming fondness for catching orphans, locking them in the tiny cell in his office, and having the police ship them away to the local orphanage for even the most petty of crimes (As it turns out, Gustav himself is an orphan, and a fate similar to the one he imposes upon these children taught him order and a certain kind of heartlessness).

However, also expect demonstrations of upcoming titles and maybe announcements on upcoming titles coming for 2009 as we are still awaiting the fate on Tom Clancy's Splinter Cell Conviction.

The events of this title follow those of Fate / EXTRA, in which the world of SE.RA.PH is controlled by the all - powerful lunar super-computer known as the Moon Cell Automaton.

Right now you can find information on some new game releases, including Super Street Fighter IV, Splinter Cell Conviction as well as a review of the blockbuster Avatar or why not check out the Anime section and a look at Fate Stay Night.