Sentences with phrase «as cell models»

To facilitate the search, I utilize discoveries and insights from various fields, including evolution, functional genomics, natural (dog) and artificial (mouse) model organisms as well as cell models.

Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.

Not exact matches

Are you setting up a recurring revenue model where you bill your customer once a month, like a cell phone plan, or a software as a service product?

As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.

Finite human freedom can be realized only in something objective, even if this were to be thought of as consisting merely in brain cells, conceptual mechanisms, associations, that is, basically in social or psychological models of thought, or if it were to belong — but only seemingly — to a merely inner realm of thought.

Dennis has a PhD in genetics / developmental biology from the University of British Columbia and a special interest in studying pattern formation and cell - cell communication during tissue development using fruit flies as a model organism.

that which asks whether certain possible machine - like entities, such as DNA or the cell, can be viewed actually as machines; and that which discusses the nature of machines that are translations of nonmachine - like models or theories.

Birch and Cobb maintain that the ecological model is more adequate than the mechanical model for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).

5 The analogy is imperfect because motile cells such as white blood cells are not connected to other cells and so, according to this model, would be completely surrounded by interstitial stuff.

In the ecological model the elements in the cell relate to one another and to the cell as a whole, more like the way an animal as a whole relates to its environment.

In the ecological model of nature all molecules and cells are recognized as subjects.

Also, the NCM460 cell line that Dr. Ebert and the carrageenan lobby criticize is derived from normal colonic mucosa and is useful to model effects on colonic cells, in the same way that other intestinal cell lines, such as Caco2 and HT29, are useful.

Before we established in - house human taste cell (HTC) technologies, it was not possible to use human tongue - derived cells as a model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.

While our work has used mouse models because we can study the process in detail this way, we do know that milk cells cross into human babies as well.»

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organAs well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organas allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Currently, I work on three directions: (1) cell motility and the cytoskeleton, (2) modeling of physiology and diseases (such as autoimmune diabetes), and (3) swarming and aggregation behaviour in social organisms.

«The fact that a [cell] culture expresses most genes present in the brain says nothing about its appropriateness as a disease model,» says Knoblich.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

Researchers at the University of Pittsburgh and Magee - Womens Research Institute (MWRI) have devised a cell - based model of the human placenta that could help explain how pathogens that cause birth defects, such as Zika virus, cross from mother to unborn child.

Stuart Hameroff, an anesthesiologist who has spent many years studying brain functions, has collaborated with renowned Oxford University polymath Roger Penrose on a model that explains consciousness as the result of quantum processes occurring in tiny structures called microtubules in brain cells.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

For Gorbunova, Pereira - Smith also serves as a role model in another way: Gorbunova, too, works with her husband, cell biologist Andrei Seluanov.

Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

Today's version of the NPS1 model includes a digital simulation of every building in the area affected by the bomb, as well as every road, power line, hospital, and even cell tower.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

A second type of immune system cell, called regulatory T cells (Tregs), are a model of constancy, remaining stable even as Teffs go into battle mode.

The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

These cells have improved the mechanical function in every other species in which they have been tested, so we are optimistic they will do so in this model as well,» Murry said.

The Virtual Cell, or VCell as it's known, is a software platform that offers the most comprehensive set of modeling and simulation capabilities for cell biology in the woCell, or VCell as it's known, is a software platform that offers the most comprehensive set of modeling and simulation capabilities for cell biology in the wocell biology in the world.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Although still far from complete, these maps are poised to serve as scaffolds for newly sophisticated models of how cells operate.

However, he added, the patient - derived iPSCs are highly useful as a model cell system for investigating blood disorders.

«Josh wanted someone to come in and build a model of single AII cells to try and understand how the AII works as an input / output device,» Cembrowski explains.

«The model we are proposing is one wherein colon cancer cells release an enzyme outside the cell, where it attaches a high - energy phosphate to the metabolite creatine, and then imports this energetic metabolite into the cell to be used as energy,» Tavazoie says.

As a result, they can now test drugs directly on living cells afflicted with the disease, and they can accurately model how it progresses.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

This is particularly important as it indicates the method can be used in a variety of cell types to create disease models and contribute to the discovery of new disease - specific therapeutics.

Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on cells derived from patients.»

Here they used the UK - developed EPOCH «particle - in - cell» code, where particles are modeled as «chunks» that describe the bigger reality of the dynamics of the plasma system.