Sentences with phrase «as cell proliferation»

NR3C1 alters a receptor in cells that binds to cortisol, and is involved in inflammatory responses as well as cell proliferation and development.

In the second webinar, you will learn how to apply basic concepts of flow cytometry to topics such as cell proliferation, dead cell exclusion, and intracellular staining techniques for transcription factors and phospho - proteins.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

This means that the tumour becomes smaller as cell proliferation decreases.

For instance, it has already been shown that the prion protein participates in events such as cell proliferation, differentiation and survival.

Not exact matches

One factor behind this evolution is that fact that the internet's main rivals as communications channels (general - audience broadcast advertising, phonebanking / robocalls and direct mail) are all gradually losing effectiveness as a result of a variety of factors including increased competition for viewer attention, cable channel proliferation, cell phone ubiquity, and overall junk - mail resistance.

IPS cells have high proliferation rates and are not yet specialized to perform functions, such as being part of the skin.

In recent years it was also observed that it can function as a metabolic «signaler» that inhibits a biological pathway found in almost all higher life forms — the ability to sense when food has been eaten, energy is available and it's okay for cell proliferation, protein synthesis and growth to proceed.

We will then seek to develop the most promising of these into novel drugs for cancers, such as those of the breast, where up - regulation of this c - FLIP is believed to be important in cancer cell proliferation.»

In the majority of cases, UV damage leaves a unique mutational footprint behind and as a result unstoppable cell proliferation is induced.

The result is increased cell growth, also referred to as compensatory proliferation, which can lead to tumour development.

«Bone cells aren't solely studied in isolation in the lab as both local and systemic factors play an important role in their function, so it's important to unpick the multitude of biological factors that can affect their proliferation,» says Dr Pablo Roman - Garcia, a first author from the Wellcome Trust Sanger Institute.

In Arabidopsis, as in most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue types.

As an example, he cited his previous research on baked purple potatoes that have compounds that help suppress chronic intestinal inflammation elevated from a high - calorie diet and stem cell proliferation, which are linked to both colitis and colon cancer.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.

The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cancer cells by switching biochemical engines from energy manufacturing reactions to anabolic reactions, which primarily support growth of the cell size and proliferation.

MAPK regulates cell functions, including proliferation, gene expression, differentiation, cell division and a form of cell suicide known as apoptosis.

As described in the article, when NANOG was increased in these mice, the epithelia showed an increase in cellular proliferation, hyperplasia, and an increase in the amount of DNA damage in the cells.

«We're looking at the genes and gene networks involved in stem cell proliferation, meristem development and flowering and branching,» said Van Eck, «with the end goal being that maybe genes that we identify in tomato, which is strictly being used as a model, might help us understand what can be done to increase yield in other crops.»

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

For years, attempts have been made to understand the mechanism behind the proliferation of cancer cells: they need metabolites to grow and proliferate as much as a vehicle needs gasoline or electricity to move.

In the case of planarians, the gene egr - 4 seems to perform an early control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.

What makes this technique novel is the accompaniment of an imaging agent known as Ga - 68 DOTATOC, which binds to somatostatin receptors in neuroendocrine cells that use the hormone somatostatin to mediate endocrine function, the release of neurotransmitters and cellular proliferation.

This protein plays an essential role in the development of certain cancers, as it can activate or inhibit the proliferation of malignant cells.

Combined, the molecular processes involving the HIPPO / TAZ / YAP and Gαs feedback circuit indicate it acts as a fulcrum that balances Schwann cell proliferation and differentiation in peripheral nerves, according to the authors.

However, they are expensive and have issues such as being prone to deterioration in terms of their cell proliferation effect.

Dr. Kirino says that «further studies to understand how SHOT - RNAs promote cell proliferation may lead to the use of SHOT - RNAs as potential target candidates for future therapeutic applications in breast and prostate cancers.»

The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.

The authors say it is possible that the combination of having an older father and no siblings may promote cell proliferation in those individuals with an underdeveloped immune system and, as such, favors the development of cancers related to the immune system, like lymphoma.

Analogous to bacterial infection, CpG - B triggers the differentiation of both plasmacytoid and conventional DCs, as well as the proliferation and activation of B cells.

The balloon angioplasty, in addition to opening the artery can lead to smooth muscle cell proliferation, similar to formation of scar tissue, known as neointimal hyperplasia.

Why it matters: Because the secretome is important for tissue function and equilibrium as well as cell communication, proliferation and organization, studying these proteins may lead to new treatments and biomarker discovery.

Yamanaka and Takahashi began their search by studying embryonic stem cells in the hope of identifying the genes that underlie essential stem cell characteristics, such as pluripotency and proliferation, a cell's ability to replicate itself.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

We use the fission yeast, Schizosaccharomyces pombe, to study the dynamic changes and plasticity of gene expression programs as a function of cell proliferation, quiescence and ageing, and the effect of various genetic and environmental perturbations.

Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research.

The addition of IL - 2, as expected, enhanced the proliferation of WT T cells, but not completely to levels observed with DGKζ − / − CD8 + T cells + IL - 2 or to Cbl - b − / − and DKO CD8 + T cells (Fig. 3D).

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.

Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency.

For (D)--(F), 5 × 104 Stemcell Technologies — purified naive CD8 + T cells were incubated with 0.3 μg / ml anti-CD3 Ab at 37 °C for 72 h. Cells were surface - stained for viability and evaluated for proliferation as assessed by dilution of CFSE within CD8 + - gated cellscells were incubated with 0.3 μg / ml anti-CD3 Ab at 37 °C for 72 h. Cells were surface - stained for viability and evaluated for proliferation as assessed by dilution of CFSE within CD8 + - gated cellsCells were surface - stained for viability and evaluated for proliferation as assessed by dilution of CFSE within CD8 + - gated cellscells (D).

Deletion of DGKζ or Cbl - b comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cells.

In these tests, StemFit not only delivered higher cell proliferation, but also showed characteristics such as homogeneity of gene expression compared with iPS cells cultured with four other media without any chromosomal abnormalities.

Immunoblots showed almost complete inhibition of mTOR expression (as shown in Fig. 4B) that resulted in decreased cell proliferation as assessed by MTS assay (A).

(c) Proliferation curves of the parental cells, hypoxia - exposed cells (A3), and the cycling hypoxia - selected subpopulations grown as adherent cultures (top two plots) or as spherical cultures (the third plot).

The appearances under phase - contrast microscope of human satellite cell cultures during proliferation and differentiation are shown in Figs. 1a and b. Cell cultures were allowed to differentiate for 4 days before cell cultures were exposed to the different insulin concentrations for 4 days as described in research design and methcell cultures during proliferation and differentiation are shown in Figs. 1a and b. Cell cultures were allowed to differentiate for 4 days before cell cultures were exposed to the different insulin concentrations for 4 days as described in research design and methCell cultures were allowed to differentiate for 4 days before cell cultures were exposed to the different insulin concentrations for 4 days as described in research design and methcell cultures were exposed to the different insulin concentrations for 4 days as described in research design and methods.

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

Three leukemias that affect as many as 100,000 people in the United States are all caused by acquired mutations that alter a specific enzyme controlling blood cell proliferation, according to new...