Sentences with phrase «as cells from the blood»

Professor Karim Raza, University of Birmingham, said, «Our findings were unexpected as we initially thought that cells from the inflamed rheumatoid joint would respond just as well to vitamin D as cells from the blood.

Not exact matches

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

According to WebMD, «Inflammation is a process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses.»

If the baby is premature, or stressed from a difficult birth, or the infant of a diabetic mother, or more than the usual number of red blood cells are breaking down (as can happen in blood incompatibility), the level of bilirubin in the blood may rise higher than usual levels.

You probably won't return to your pre-pregnancy weight for some time, but you'll continue to lose weight during the postpartum period as your body eliminates all the extra water your cells retained during pregnancy, along with fluid from the extra blood you had in your pregnant body.

High levels of cortisol in the blood and separation from mother may negatively impact immune function as the body may stop producing leukocytes (infection fighting cells).

A 50,000 unit blood bank would provide economies of scale that would reduce the cost to the NHS for every treatment as well as radically reducing the need to import stem cell units from abroad, which is a common and expensive practice today.

While the Vortex system is designed specifically for blood, the company is working with academic researchers to develop versions that could be used to isolate cells from other body fluids as well, such as cerebrospinal fluid and urine.

For over one hundred years, scientists have debated the question of the origins of the lymphatic system — a parallel system to the blood vessels that serves as a conduit for everything from immune cells to fat molecules to cancer cells.

Davis suggests that the muscle cells start extracting fat directly from the blood and somehow transport this fat across the cell membranes and into the cells, where it can be burned as fuel.

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

As the heart starts pumping a primitive blood - like fluid around the body of an embryo, the change in pressure from the flowing liquid is the cue for cells lining the aorta to change first into blood stem cells, then into all blood - cell types in the body.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Today in Cell and associated journals, 24 research studies from the landmark BLUEPRINT project and IHEC consortia reveal how variation in blood cells» characteristics and numbers can affect a person's risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, celiac disease and type 1 diabetes.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

The insulin these cells produced acted on blood sugar levels in the same way as insulin from the pancreas.

The plan is to extract blood - forming stem cells from a patient's bone marrow and correct as many copies of the mutated gene as possible.

And the cells in our body differ from one another — serving as neurons, white blood cells, smell sensors, and so on — largely because they activate different sets of genes and thus produce different mixtures of proteins.

They will have to address side effects such as the flulike symptoms and the kidney failure that occurred in one patient due to all the dead cells the body had to cleanse from the blood.

«We began with stem cells taken from cord - blood, which have fewer acquired mutations and little, if any, epigenetic memory, which cells accumulate as time goes on,» says Zambidis, associate professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.

Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.

Another key finding of the research was that the impact of vitamin D on inflammatory disease can not be predicted using cells from healthy individuals or even from the blood of patients with inflammation as cells from the disease tissue are very different.

These are cells taken from adult non-muscle tissues, such as skin or blood, and reprogrammed to revert to a primordial state.

As fluid and white blood cells rush to the damaged tissue, it becomes inflamed in an effort to repair the tissue and protect it from further damage.

As a result, these blood vessels will be structured more tightly, which can prevent cancer cells from spreading to other organs.

Known as the blood - brain barrier, cells that line the brain and spinal cord are tightly packed, making it difficult for anything besides very small molecules to cross from the bloodstream into the central nervous system.

Y. pestis was initially passed from person to person — say, when an infected individual coughed on a healthy person — and most likely caused lung infections known as pneumonic plague or blood infections called septicemic plague, the researchers report October 22 in Cell.

As expected, white blood cells grown from these altered stem cells were resistant to HIV upon testing.

Insulin is an enzyme that helps transport sugars from the blood into cells for use as fuel.

As expected, white blood cells grown from these altered stem cells were resistant to HIV (PNAS, doi.org/s5t).

The implications were hardly lost on the Bethesda crowd: If the virus was transmitted in cell cultures in Ruscetti's lab, it could also be contaminating the nation's blood supply as a result of blood donations from unknowingly infected donors.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

But when researchers injected Anas platyrhynchos ducklings at 4, 9, or 14 weeks old with red blood cells from sheep to simulate a parasitic infection, the birds — as adults — explored new items in their environment and approached small orange toys, a color they typically avoid because they seem to associate it with toxic food.

Deletion of the CXCR4 gene led to sustained T - ALL remission within a month in similar mice, as well as movement of the cancerous blood cells away from the bone marrow.

To understand how these multi-colored lesions originated they examined blood from these mice and found that tumor cells in circulation frequently occurred as clusters comprised of different colored cancer cells.

And researchers must figure out how to build in some core features: the necessary blood vessels, immune - system cells called microglia and connections from other brain regions, such as the thalamus and cerebellum.

They found that when fibrinogen (a blood - clotting protein) leaks into the central nervous system, it stops brain cells from producing myelin and, as a result, prevents repair.

Various reports in recent years have claimed that stem cells from one tissue — for example, blood — can mature into other tissues such as muscle or brain.

Although embryonic stem cells are naturally pluripotent, iPS cells are created by scientists from existing adult cells, such as skin or blood.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

With gene - editing tools such as CRISPR, scientists can now eliminate immune - provoking sugars from the surface of pig cells, introduce human genes that regulate blood coagulation to prevent dangerous clots, and snip out viral sequences that some fear could infect a human host.

Now a team from the Massachusetts Institute of Technology reveals that the support cells dubbed astrocytes (because of their star - shaped bodies) form the link between neurons and blood vessels, as reported in the July 7 issue of the Proceedings of the National Academy of Sciences.

In the current study, the researchers showed that FGPs are present on the surface of the zebrafish brain and that these blood vessel - associated FGPs do not arise from the immune system, as had been previously thought, but from endothelial cells themselves.

Sumitran - Holgersson says she hopes in future to try using blood vessels from animals for re-coating with patients» own cells, as the source would be potentially limitless.

Kohn's gene therapy approach using HSC from patient's own blood is a revolutionary alternative to current SCD treatments as it creates a self - renewing normal blood cell by inserting a gene that has anti-sickling properties into HSC.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

A series of headline - grabbing results in the late 1990s and early this decade suggested that specific adult stem cells such as those from the blood seemed able to exceed expectations and transform themselves into other organs and tissues.

A number of new clinical trials aim to take cells from a patient, such as blood cells or immune cells, edit them and transfer them back with new power to undermine diseases like cancer or sickle cell anemia.