Sentences with phrase «as cellular senescence»

Cells treated with palbociclib irreversibly withdraw from the cell division cycle and enter a state referred to as cellular senescence.

Not exact matches

This series addresses the contribution of cellular senescence to cardiovascular, neurodegenerative, and arthritic disorders as well as the senescent phenotypes in various tissues and cell types.

P16: P16 is perhaps best known as an indicator of cellular senescence, a part of the mechanisms that cause damaged cells or those at the Hayflick limit to become senescent or self - destruct.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

Part of this is a pathological redistribution of adipose from the subcutaneous to the visceral depot, but it now emerges that the subcutaneous depot becomes qualitative as well as quantitatively abnormal in the degenerative aging process also suffers genuine age - related lipoatrophy and lipodystrophy — and that p16Ink4a - driven cellular senescence is at the heart of it.

In recent years, cellular senescence has been proposed as a mechanism that may be involved in lung fibrosis.

What is particularly interesting is that AGEs have been shown to induce premature cellular senescence, suggesting that high glucose levels associated with diabetes likely accelerates ageing in other tissues that consequently manifest as disease.

Using replicative senescence as a cellular model, we will dissect the functions of ATR and ATM in the process of aging and in premature aging diseases.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

When this occurs, a cell enters into a state of growth arrest known as «cellular senescence,» which is the cellular equivalent of aging.