Sentences with phrase «as chimeric»

These three artists share a penchant for the garish and provocative: through the use of bold colors and tantalizing aesthetics, their artworks portray disconcerting human stereotypes as well as chimeric monsters.

An interrelationship exists between viral - vector upstream and downstream bioprocessing strategies and those for other therapeutic platforms such as chimeric antigen receptor (CAR) T cells and induced pluripotent stem cells (iPSCs).

Research into such therapies as chimeric antigen receptor T cells (CAR - T) cancer therapies and stem - cell regenerative medicines demand the isolation and purification of viable and functional target cells.

Precious patient samples, contamination concerns, and limited product purification options have compelled manufacturers of cellular immunotherapies (iTx) such as chimeric antigen receptor T cells (CAR - T) and T - cell receptor (TCR) technologies toward the disposables industry.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

«And given the state of the chimeric restriction endonuclease art prior to the patent's 1999 date, there are some serious doubts as to its validity.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

The team developed a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 — the same fragments to which PV - causing antibodies and their B cells typically bind, as Payne's laboratory and others have shown in prior studies.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

Richard Vague, the event's honorary chair, took the podium to acknowledge the vast achievements of the ACC, as did Lori Alf, a multiple myeloma patient of Edward Stadtmauer, MD, chief of Hematologic Malignancies, whose cancer is in remission after receiving chimeric antigen receptor (CAR) therapy.

Gross G, Waks T, Eshhar Z. Expression of immunoglobulin - T - cell receptor chimeric molecules as functional receptors with antibody - type specificity (chimeric genes / antibody variable region).

Diagram of the complete synthetic signal transduction system in transgenic plants, using TNT as the ligand, signaling through the bacterial chimeric histidine kinase, and adapted response regulator, then activating a transcriptional response.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

Importantly, stimulation of the crosslinking of CD4ζ chimeric receptors led to tyrosine phosphorylation as would be expected for a fully functional chimeric receptor.

Interestingly, the chimeric mice can be directly used to monitor tumor development as they contain the same genetic alterations as the original GEMM including the altered target gene expression.

Four chimeric mice were derived and correct homologous recombination as well as germline transmission of the Boule mutation was confirmed.

In addition, mixed lymphocyte cultures using the cells of the chimeric animals as responder cells to donor splenocytes failed to demonstrate any sensitization or clonal deletion of alloreactive T cells; i.e. T cell responses were identical to those of control animals (n = 4)(data not shown).

The exclusive, worldwide license, announced Sept. 14 by Mustang Bio, will allow a new type of CAR (chimeric antigen receptor) T - cell therapy to be tested in a clinical trial as a treatment for B - cell non-Hodgkin lymphomas.

Balb / c third - party allografts were acutely rejected in chimeric animals, as were control MRL allografts in non-chimeric animals.

In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment.

First, they remain in the offspring after birth and are related to the HLA genes, and second, chimeric cells are not merely present in the children — but they are active, as shown by the attacks they mount against the child's body.

It functions as something of a brilliantly mellifluous backbone to the film and the series that spawned it — chimeric and socially significant, again like Bird's bebop, in that the 26 - episode Japanese television series became one of the most recognized and revered crossovers in animated series history.