Sentences with phrase «as chloroquine»

We have also investigated whether inhibition of MHC class II antigen presentation by lysosomotropic agents such as chloroquine can inhibit T cell responses to MiHC and development of GVHD.

The inspection of several databases led to the identification of structural similarity between such lead and numerous quinoline or acridine derivatives, such as chloroquine, hydroxychloroquine and quinacrine.

One problem is that the malaria parasite is becoming resistant to drugs, such as chloroquine, that have been used as treatment for many years.

Instead, many people end up with less expensive but ineffective drugs such as chloroquine and artemisinin monotherapies, which increase the risk of drug resistance.

In these experiments, the botanical tea performed as well as chloroquine and quinine.

It is key to its antimalarial property and makes artemisinin - based drugs entirely different from those derived from quinine, such as chloroquine, to which malarial parasites have become resistant.

Not exact matches

Treating malaria with chloroquine is no longer a viable option for most people as the parasite has developed resistance to the drug.

«Anti-malaria drug shows promise as Zika virus treatment: Chloroquine reduces transmission of Zika virus from mother to fetus.»

«In the 1950's, the Brazilian health agencies added chloroquine into cooking salt and distributed it to the population in endemic areas as an effective way of spreading the inexpensive anti-malarial drug as a prophylactic on a wide scale.

The earliest sightings of chloroquine - resistant parasites date as far back as the late 1950s and early 1960s.

As soon as the pathogen enters the bloodstream, however, it can be killed by chloroquine — and the disease can not break ouAs soon as the pathogen enters the bloodstream, however, it can be killed by chloroquine — and the disease can not break ouas the pathogen enters the bloodstream, however, it can be killed by chloroquine — and the disease can not break out.

They separately injected six chemicals that make humans itch, such as histamine and the antimalarial drug chloroquine, under the mice's skin and noted how much the animals scratched.

For a group of malaria drugs called the quinolines — which includes former mainstays such as quinine and chloroquine — scientists have tried to develop «resistance reversal agents,» secondary drugs that undo the resistance.

Using chloroquine, the researchers not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumors.

And its twin pillars soon crumbled as P. falciparum evolved resistance to chloroquine and mosquitoes evolved resistance to DDT.

Conclusions: The predominance of the Pf pfcrt CVIET and Pf dhfr IRN triple mutant parasites and absence of pfkelch13 resistance alleles suggest that the amodiaquine and pyrimethamine components of AS - AQ and SP may no longer be effective in their role while chloroquine resistance still persists in southwestern Cameroon.

Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.