Sentences with phrase «as copy number»

Molecular phenotypes, such as copy number variations and structural variations can be detected, quantified and analysed in similar ways.

This type of disorder is also known as a copy number variation (CNV).

He notes that because of the boggling number of potential factors, such as copy number variations, point mutations and epigenetic (inherited mutation) factors involved in autism, it will be important to find common pathways «because the mechanisms interrupting those pathways might be different among individuals.»

This difference in repeat number is known as copy number variation, and is more common than previously thought.

Not exact matches

Haik and Moretti say Mic is also tracking time spent on a page along with other metrics such as repeat visitors, scroll depth (how far a reader gets into a story before they click away), and the number of times content is copied and pasted into a post, tweet, or email.

If the box's channels don't have your entertainment options covered, you can easily copy video onto a USB stick and plug it in, with a number of channels / apps such as Plex also helping with streaming from a computer.

While there are certainly a stable of proven sale strategies that are widely applicable to growing your startup regardless of the industry you're in, it's not quite as simple as copying, pasting, and kicking back to watch your numbers soar.

While some rights holders have argued that the standard for a substantial is very low (the National Post recently argued in a case that «even the reproduction of a small number of words in a newspaper article can be an impermissible reproduction»), the Copyright Board says that its preliminary view is that «copying of a few pages or a small percentage from a book that is not a collection of short works, such as poems, is not substantial.»

If you would like to revoke your consent to householding and in the future receive your own Notice of Internet Availability of Proxy Materials (or your own set of proxy materials, as applicable), or if your household is currently receiving multiple copies of the same items and you would like in the future to receive only a single copy at your address, please contact Householding Department by mail at 51 Mercedes Way, Edgewood, New York 11717, or by calling 1-800-542-1061, and indicate your name, the name of each of your brokerage firms or banks where your shares are held, and your account numbers.

Also, we'll be covering a number of other A / B testing topics as part of this series, including website copy, email campaigns, pay - per - click advertising, and SEO landing pages.

To get a phone number, it's simple to set up a local SIM card, as long as you have a copy of your passport and address.

You should also have a copy of your drivers license handy, as well as the social security numbers of everyone whose name will be listed on the mortgage.

In this video I'm going to show you a great way to get better keywords out of the Google Adwords Keyword tool if you haven't seen the previous video you'll want to watch that video where I show you how to get better search volume numbers from both google adwords as well as some other sources to get better estimates for the amount of times that keyword is searched each month i'll put a link in the video here so that you can click that video if you haven't seen that yet let's get started now if you want better results from the Google Adwords Keyword planner you have to work a little differently than everyone else so most people come to the Google Adwords Keyword planner and they simply click on this search for new keywords using a phrase, website, or category and then they just paste a bunch of keywords into this text box so let's say as an example that these were our starting keywords ok so let's say we have the keywords «fishing tips» «fishing tackle» «fishing for bass» «fishing rod» and «fishing reel» what most people do is that they would simply come here and they would copy this they would paste it into this field and they would hit Search and they would get back their results and that's fine but one little tip that will help you get much better results is only paste in one key word at a time so instead of pasting all these in just paste in the single keyword «fishing tips» and then proceed from there to pull that those results up and you'll get this back if you click right here you can download the ideas you'll notice they're 701 here listed so if we download these ideas will download them to a CSV file comma separated value file you can open that with notepad you can open it with excel open office when you're finished putting all your ideas and individually you will now have a bunch of different common separate value files containing the keywords and the search volume I've already gone ahead and done that just to save time on the video but i want to show you what happens when you use this method versus just pasting in the keywords like most people do so here you'll see this column here represents these two columns here represent if we had pasted in all of the keywords at once and click search at google adwords keyword tool is one that showed you and you'll see we have a total of 706 results we got back when we did that this column this column here represents what happens when we paste one key word at a time and then download the file paste the second keyword download the file and then we just simply grab those terms and copy them and you'll see now we have a total of 1,915 keywords now what I've done with the highlighting here is to show you anything that's not highlighted in this column is a keyword we would not have gotten back had we pasted in all the keywords at once you can see there's lots and lots of keywords here we would not have seen know your competitors and the company's you're competing against they're using probably the simple method just pasting a bunch of keywords sitting search and then looking through those terms to find their terms if you will take the extra few minutes it takes doesn't take long to simply go in and paste one key word at a time you will get back a ton of great keywords that others aren't seeing because they're using this other method and in actuality when I ran the numbers there's a total of 3.8 million searches represented by these keywords here that you would miss if you simply just copied and pasted those five terms and hit search the Google Adwords Keyword planner once you've used the google keyword planner to find lots of new keyword ideas what do you do with all those keywords the biggest problem is that you can there are so many keyword tools out there you can get hundreds of thousands of keywords by spending a day using the different keyword tools but what you do with all that information the answer is a cool tool called keyword grouper pro and Keyword Grouper Pro is completely free there's not even an opt in you just simply download the tool now at the top of this video there's a link if you click that i'll show you exactly how to use keyword grouper pro doesn't matter where you got your keywords from i'm going to show you how to take those keywords group them into tight groups and then you can set up your campaigns and know exactly which groups represent buyers and once you know where the buyers are at you can simply focus your marketing in that area to make more profit in your business

I have a number of copies of these before me as I write.

I believe because the evidence is continuing to back the Bible and as I said earlier the number of ancient copies of the Bible is inscribe, way over a hundred, and they all match, although there are sometimes variations, they agree with one another.

I'm pretty sure that my copy will have the same number of bookmarks as yours!

Once your list is complete, email us your name and telephone number as well as a photograph or photo - copy of your military or first responder ID.

Copies of texts supplied by Matt Seaton and Chris Sharpe, as well as photos of pictures and winners from the «Images of Fathers» exhibition (in print and email format) are available from Fathers Direct and from the Lloyds TSB Foundation (contact numbers attached).

So what we did was once the plates were dry was draw a circle — some I did and some J did — as I wanted us to look at numbers and symmetry but without J realising it so I drew a line down the middle of the plate — on one side I drew either 1, 2, 3, 4 or 5 circles and then J copied them on the other side of the line he did it really well.

and you were the one throwing around Cuomo's numbers, which obviously you made up or just copied from Cuomo as you're doing research now.

So his campaign released a television ad as rudimentary as any broadcast that political season, featuring a number of prominent politicians — City Council Speaker Christine Quinn, West Side Congressman Jerry Nadler, Manhattan borough president Scott Stringer — carrying a folded copy of The New York Times, while reading from its endorsement of his candidacy.

It is also crucial that such information is available in hard copy format as well as online to help the substantial numbers of taxpayers who are either digitally excluded or find it difficult to engage with government online.»

But there is widespread concern within the industry about the quality of journalism being published online, with «clickbait» often ruling the roost and the performance of reporters being judged solely on visitor numbers as opposed to the standard of their copy.

Applicants must bring a copy of a recent utility bill as well as documentation verifying income, rent, and the date - of - birth and social security number of each household member.

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

As the name indicates, the copy number variants are many and new (de novo).

This change, known as somatic copy - number alterations, may be key to disease progression and might offer new therapeutic approaches for ovarian cancer and other malignancies.

Extra bases are easily added or lost when the DNA is copied, so the number of repeats in each of these stretches, known as microsatellites, varies widely from one individual to another.

These primers allow the DNA to be copied (in a process known as PCR), to build up a sufficient number of copies that can be read by a DNA sequencer.

A strong, male - biased mutation spectrum was also measured, wherein three - quarters of mutations occurred in sperm thorough spermatogenesis, as well as new structural alterations, such as changes in gene conversion and copy number.

Both the hunter - gatherers as well as the early farmers displayed high copy numbers of amylase genes in their genomes, suggesting that both populations had already adapted to a starch - rich diet.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

By studying rare «copy number variations,» which are individual errant insertions or deletions of DNA segments (each of which occur in less than one percent of the population), researchers discovered a new cluster of genes that are affected in some autistic individuals as well as a number of mutations that were present in autistic children but not their parents.

As all school - children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA - containing chromosomes are separated into two distinct cells.

«We also showed that as the number of mutant KRAS copies increases, the tumor's aggressiveness and ability to metastasize also increases.»

As with most cancers, triple - negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

«Our preliminary data in cancers such as prostate, colon, liver and lung suggest a punctuated model of copy number evolution is also likely to be operative in other solid cancers,» said Navin.

Mark Daly, an assistant professor of medicine at Harvard University Medical School and MGH as well as co-author of the NEJM study, notes that «It is extremely unusual to see these spontaneous deletions and duplications in a region that's usually a copy number — stable region.

«The general approach of looking at copy number variation as the cause for genetic disease has probably taken one of those exponential — it's probably hyper --- exponential leaps,» he says.

Citing the growing body of evidence of links between copy number variations and diseases such as autism, an international science consortium announced yesterday that it plans to sequence the genomes of 1,000 people from around the world in an attempt to flush out genetic suspects.

(Chromosome 16 is the second instance of a copy number variation to be fingered as a causative mutation of the condition.

Third generation, or great - grand offspring, had increased genetic mutations, which the researchers saw in increased DNA structure changes known as copy - number variations.

There are a number of viruses that have a similar way of copying themselves — a process that reverses the normal flow of information in cells, which is where the term «retro» comes from — and their central machinery for replication may be a bridge from the original life - forms on this planet to what we know as life today.

These «copy number variations» have been linked to other conditions such as autism, but never before to cancer.

Using a specific work flow, they assessed both the coding and noncoding regions of the human genome, including the evaluation of highly polymorphic SNPs, structural and copy number variations, as well as 69 control genomes sequenced by the same procedures.

This murine model system offers a superior source of immortalized cell populations as many of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites of gene integration, multiple copy number; Ref.

However, such CRISPR screens are sensitive to a phenomenon called the copy number effect, where genes that have been repeatedly duplicated within a cell (as commonly happens in cancer cells) can be flagged as essential regardless of whether they are or not.

These new data suggest that transcriptome analysis can be used as a tool to predict the protein copy numbers per cell.

The patterns of somatic copy number changes, as assessed by high - density SNP array, suggest widespread segmental CNA instability:

The development of high - throughput screening methods such as array - based comparative genome hybridization (array CGH) allows screening of the human genome for copy - number changes.