Sentences with phrase «as cyclin»

For instance, Cluster 1 contains genes such as cyclin A2, cyclin B1, cyclin E1, cyclin F, polymerase alpha 2, RNA polymerase II polypeptide H, and RNA polymerase III polypeptide G, whereas Cluster 3 genes include Nanog, Sox2, Pou5f1 (Oct4), Klf2, Zpf42 (Rex1) and Esrrb.

We also need to know if there are other non-HRD factors, such as cyclin E positivity, that predict which patients will respond to treatment.

Dinaciclib is a member of a class of drugs known as cyclin - dependent kinase (CDK) inhibitors.

Not exact matches

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

This led me to enter the field of developmental and cell biology, and to eventually discover cyclin as a key regulator of the cell cycle.

All textbooks describe the cyclin - dependent kinase complex as the one and only / exclusive regulator of the eukaryotic cell cycle.

As their name suggests, these proteins are regulated by cyclins.

Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer.

Other gene abnormalities were, on the other hand, encountered in the other groups, such as c - Kit [19], cyclin - dependent kinase 4 (CDK4) and cyclin D1 (CCDN1)[20, 21].

Cyclin A2: Increased levels of cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the Cyclin A2: Increased levels of cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the heart.

The immunohistochemical staining appeared as brown staining granules in the nuclei as positive expression of Cyclin D1, while the nuclei having blue color indicated negative reaction.

These finding were exactly in accordance with Gillet et al., 1996 [24], who stated that, Cyclin D1 staining did not appear to correlate with an increased S - phase fraction as judged by flow cytometry.

Furthermore, there was a negative expression for Cyclin D1 protein in normal ductal epithelial cells, while the benign group revealed week positivity immunostaining Cyclin D1 in 60 %, whereas, the malignant group represented a variable positivity of immunostaining scores; they were classified as 3 (10 %) cases were weak, 9 (30 %) moderate cases and 12 (40 %) strong expression cases.

SO, they had suggested the inhibition of cyclin Dl / CDK4 activity might be important in considering drugs of future therapies [25], also, they reported that Cyclin D1 was considered as a significant prognostic mcyclin Dl / CDK4 activity might be important in considering drugs of future therapies [25], also, they reported that Cyclin D1 was considered as a significant prognostic mCyclin D1 was considered as a significant prognostic marker.

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

No significant correlation was observed between Cyclin D1 staining and S - phase % obtained by flow cytometry as illustrated in Table 5.

As regard to cyclin Dl expression, the present result showed that it was mostly nuclear staining with variable range of stain intensity between different sections in the individual groups.

This contradictory behavior explained that Cyclin D1 acts as a negative regulative protein under some conditions rather than a positive regulator in the cell cycle, i.e. the modest increase in Cyclin D1 expression could hasten the G1 phase while the overexpression may lead to block the progression through the S - phase [28, 29].

Validation of Cyclin D1 / CDK4 as an anticancer drug target in MCF - 7 breast cancer cells: Effect of regulated overexpression of Cyclin D1 and siRNA - mediated inhibition of endogenous Cyclin D1 and CDK4 expression.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

The remaining 6 cases (20 %) did not show any considerable staining for Cyclin D1 in the nucleus and were classed as negative nuclear stain.

His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Rb and E2F remain bound together as a result of cyclin dependent kinase inhibition.

Hey Kathryn, not as long as they are healthy fats: https://drjockers.com/top-3-healthy-fats-which-fats-to-never-eat/ You will also want to consider following a cyclin ketogenic diet to balance blood sugar and lower inflammation which ar common causes of high cholesterol.