A recent study reported that two oxysterol species, 15HC and 15KC, were increased more than three-fold in the blood of multiple sclerosis patients, suggesting a potential use for these oxysterols
as diagnostic biomarkers.
Not exact matches
The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of
diagnostic imaging, discovering and verifying new
biomarkers as indicators of cancer, and developing new technologies to aid early detection.
Blood contains proteins, enzymes, lipids, metabolites, and peptides that serve
as biomarkers for health screening, monitoring and
diagnostics.
This situation is confounded by the relative scarcity of blood - or cerebrospinal fluid (CSF)-- based
biomarkers that can increase our understanding of disease pathology, and might also serve
as effective differential
diagnostic or prognostic tools.
The information potential held by miRNAs, combined with the fact that they are stable in serum and plasma, has led to a rapidly growing interest in using miRNAs in blood
as diagnostic and prognostic
biomarkers.
Thus, molecular imaging by means of PSMA - PET / CT also has an important role
as a stratification criterion, and the «theranostic» concept [combining
diagnostic imaging of a
biomarker with precise therapy] may be an additional motivation to establish PSMA - PET / CT
as a routinely available imaging modality.»
Current methods associated with epigenetics research will be discussed,
as well
as how these technologies are advancing the development of new
diagnostics and
biomarkers.
However, single
biomarkers are biologically implausible
as a
diagnostic test for complex diseases like CFS and are likely to perform poorly in larger populations.
«Lastly, the technique we have pioneered will likely be a valuable tool for scientists and clinicians studying the biology of complex nanoparticle populations,» Dr. Zhang said, «and may aid in the development of
diagnostic tests using them
as biomarkers.»
The lack of knowledge and tools highlights the importance of ongoing research leading to the development of better
diagnostic tests and
biomarkers that can predict which patients are at risk for progression from latent to active disease,
as well
as better - tolerated treatment regimens for latent TB infections, note the authors.
Reliable
biomarkers such
as that identified by the researchers offer insight into how HIV - associated cognitive impairment develops but also promises improved
diagnostic testing and improved treatment decisions.
Antibody microarrays are powerful tools for simultaneous detection of hundreds or thousands of blood - borne protein
biomarkers at once, potentially allowing accurate fingerprinting and improved
diagnostics of complex pathophysiological states such
as cancers, neurodegenerative diseases and autoimmune conditions.
Identification and analysis of
biomarkers, i.e. disease - specific indicators, with the aim of using them
as diagnostic or therapeutic tools.
Harshini Mukundan, of Los Alamos» Nuclear and Radiochemistry group made critical breakthroughs in optical detection techniques of diseases such
as tuberculosis, allowing rapid detection in the field, and discovered an entirely new class of
diagnostic molecules that led to chemical recognition of various
biomarkers.
Biomarkers included are available to order
as individual tests, or
as a comprehensive profile to help provide simultaneous
diagnostic information about multiple conditions in a single blood draw.
DNA methylation profiles of the brain - derived neurotrophic factor (BDNF) gene
as a potent
diagnostic biomarker in major depression