Sentences with phrase «as disease models»

Inbred strains of mice were used as disease models, long before the mouse genome project and transgenics.

The laboratory - based study of animals and cells (known as disease models) can be a powerful method for understanding illness.

Some ethicists suggest that tissue donors deserve a share of the tremendous commercial potential of iPS cell lines as disease models, drug - testing platforms or treatments.

«The fact that a [cell] culture expresses most genes present in the brain says nothing about its appropriateness as a disease model,» says Knoblich.

[They're] limited as a disease model, because neurodegeneration does not occur in fish.»

Several other components would be disbursed among the National Institute of General Medical Sciences (such as disease model resources), NIH's imaging institute, and its institute for minority health research.

Multi-organ platforms have an enormous potential to lead to a paradigm shift in a multitude of research domains including drug development, toxicological screening, personalized medicine as well as disease modeling.

These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (45).

Not exact matches

But aside from raising awareness and more than $ 20 million for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, over the past month, the challenge also may be unleashing a new model for the $ 300 billion - a-year business of charitable giving.

As we begin to access God's power to defeat the Sin - disease and discover and use our own legitimate power to live, we step into the spiritual world, where God shares the keys to life and reality (A Hunger for Healing: The Twelve Steps As a Classic Model for Christian Spiritual Growth [NY: HarperCollins, 1991], pp. 4 - 6).

«Future studies need to determine the health effects of these cocoas in models of human disease and to evaluate the consumer acceptability of the cocoas as part of a chocolate product.»

Therefore, it is reasonable to assume that a reduction of added sugars or SSB intake would lower the prevalences of obesity and chronic disease that are related to excess body fat as has been modeled by several groups (11, 12).

Several of these programs have received national and international recognition, including designation as model programs by the American Psychological Association, the American Medical Association, and the Centers for Disease Control and Prevention.

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

The response in Newburgh was crafted in consultation with the U.S. Centers for Disease Control and Prevention and will serve as a national model for understanding PFOS exposure, state Department of Health spokesman James Plastiras said.

The SUV members talked in detail about treating violence as a disease and why their model program is successful.

This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying psychiatric disease.

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

«It started to become quite evident to me that a research career in infectious disease epidemiology and mathematical modeling would be a fairly perfect combination of my longstanding interests in math and biology and medicine, as well as my emerging interest in infectious disease transmission and public health more generally,» she says.

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Thomas is a wildlife biologist by training, but he now uses technology such as satellite remote sensing and software applications such as geographic information systems to model vector disease transmission.

Currently, I work on three directions: (1) cell motility and the cytoskeleton, (2) modeling of physiology and diseases (such as autoimmune diabetes), and (3) swarming and aggregation behaviour in social organisms.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

To unravel exactly how ADAR1 is connected to disease severity at a molecular level, the researchers transferred multiple myeloma patient tissue to mice, creating what's known as a xenograft or «humanized» model.

But epidemiologists are increasingly turning to agent - based models to include factors that the equations ignore, such as geography, transportation networks, family structure, and behavior change — all of which can strongly affect how disease spreads.

This is advantageous, since dogs provide new models to investigate the disease mechanisms and to plan new therapies such as gene therapy, successfully applied to blindness in dogs and human previously,» explains Lohi.

He says they hope to be able to create miniature models of brains experiencing a range of diseases, such as Parkinson's and Alzheimer's.

Dogs already serve as models for diseases such as narcolepsy, certain cancers and blindness.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

Scientists study VSV, which causes acute disease in livestock but typically does not lead to illness in people, as a model for viruses that are harmful to humans.

«Social media data have been suggested as a way to track the spread of a disease in a population, but there is a problem that in an emerging outbreak people also use social media to express concern about the situation,» explains study team leader Sherry Towers of ASU's Simon A. Levin Mathematical, Computational and Modeling Sciences Center.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.

The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.

«Computational models like this one might one day be able to predict the clinical course of a disease or injury, as well as make it possible to do less expensive testing of experimental drugs and interventions to see whether they are worth pursuing with human trials,» he said.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Modern geographers and cartographers are involved in diverse projects: tracking fleets of vehicles or products, helping customers locate a Dunkin' Donuts, modeling environmental scenarios such as oil spills, and studying the spread of disease.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Some studies blame a parasite - stress model: High infectious disease rates can exacerbate tensions such as xenophobia and strain resources, elevating the risk of conflict.

«Our interest in the body's own (innate) immune system as the culprit began when we discovered that immune system agents become activated in a laboratory model of Huntington's Disease,» he says.

Flaherty, who studies conditions such as hypergraphia (an uncontrollable urge to write) and writer's block, also looks to disease models to explain the drive behind this mode of communication.