Sentences with phrase «as disease progression»

In rodents, this has been shown to translate into improvements in clinical end - points such as disease progression.

Would they have benchmarks, such as disease progression levels, for deciding who gets treatment?

Not exact matches

Where is the clear line in a progression from (1) using animal insulin to treat diabetes, to (2) using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ cells which would otherwise have transmitted the disease to one's offspring?

But as originally written, the bill redefined, as a method of killing, «the use of sedative medications to relieve extreme suffering by making the patient unaware and unconscious, while artificial food and hydration are withheld, during the progression of the disease, leading to the death of the patient.»

It has been noted that an injury to a person's blood vessels in their brain may actually dramatically alter the progression as well as onset of Alzheimer's disease.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

He says a molecular test that sorts lesions as more or less aggressive has the potential to help doctors and patients decide how to treat and monitor the progression and control of the disease.

This change, known as somatic copy - number alterations, may be key to disease progression and might offer new therapeutic approaches for ovarian cancer and other malignancies.

As might be expected, this marriage of biology and technology is also designed to find new ways of diagnosing the disease, monitoring its progression and delivering drugs to fight it.

«Our results indicate it is a promising agent for clinical trials, and a as an add - on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.»

Smith says her group is investigating whether PET imaging of serotonin could be a marker to detect progression of disease, whether alone or in conjunction with scans that detect the clumping protein known as amyloid that accumulates in the brains of those with Alzheimer's disease.

Several variants, such as the HLA B * 5701 allele, have been associated with the pace of HIV disease progression in both controllers and «normals.»

But unlike typical neuropathy patients, transthyretin amyloidosis patients develop more rapid progression of their disease as well as additional symptoms, such as problems with their digestion and irregular heartbeat, within about three to five years.

As prostate cancer progresses, tumor cells may infiltrate this periprostatic adipose tissue: this is a key step in the progression of this cancer, as it signals locally advanced disease (where the cancer can progress to nearby organsAs prostate cancer progresses, tumor cells may infiltrate this periprostatic adipose tissue: this is a key step in the progression of this cancer, as it signals locally advanced disease (where the cancer can progress to nearby organsas it signals locally advanced disease (where the cancer can progress to nearby organs).

Redfield has a long history of publishing reports about his work: In 1988 he co-wrote a Scientific American feature article about early HIV research (available via subscription only), which emphasized the importance of studying the progression of HIV into AIDS, and of diagnosing the viral disease as early as possible.

Scientists have long known that a bath of protective proteins in the brain, known as neurotrophic factors, can help curb the progression of Parkinson's disease by keeping those dopamine - producing neurons healthy.

In the end, the identification of microbial species or metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptoms.

«Our results showed that in the majority of pNETs that progress on rapalog therapy, it is possible to reduce disease progression when switching instead to an mTORKi, such as CC - 223,» Elnakat Thomas says.

The studies not only point to the future possibility of specific microRNAs as a treatment for colorectal cancer, but also to the importance of external metabolic events conducted outside the cancer cell in the progression of the disease — factors that could someday be targeted to help slow metastasis, or even block it entirely.

«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.Disease amongst others.»

Progression - free survival in the trial escalated from 3.5 months to 9.7 months with the addition of radiation therapy delivered to all the metastatic sites of lung cancer as well as the primary disease site.

«Although there is a high risk of progression to decompensated cirrhosis and liver cancer among patients with advanced fibrosis, limiting access to people who have already progressed to late - stage disease as compared to treating earlier to prevent these liver - related complications seems counter-intuitive as a public health strategy.»

Early diagnosis and therapy has been identified as a potentially crucial step in achieving optimal control of disease progression and prognosis in RA.

He hopes the model will be useful for future predictions along these lines, such as looking at pathways of disease progression.

Plasma levels of this biomarker rose with kidney deterioration in patients with MMA, and may serve as a valuable indicator of MMA kidney disease progression in the clinic.

«It's early to speculate,» Kipnis says, «but I think that alteration in these vessels may affect disease progression in those neurological disorders with a prominent immune component, such as multiple sclerosis, autism and Alzheimer's disease.»

Researchers in the Jacobs School of Medicine and Biomedical Sciences at UB are continuing to study cerebral microbleeds, identified in the image above, as indicators of disease progression in multiple sclerosis.

All patients received standard first - line treatment of FOLFIRI plus cetuximab until disease progression or unacceptable toxicity, as previously reported (Ciardiello et al, Annals of Oncology 2014).

In addition, she adds, the discovery of pα - syn * as an important component of the disease process points to a new target for creating drugs slowing disease progression.

An increase in serum phosphorus levels in African Americans with chronic kidney disease (CKD) is associated with faster progression to kidney failure, known as end - stage renal disease (ESRD), according to new research presented at ASN Kidney Week 2015 November 3 - 8 in San Diego, CA.

«We do not yet have treatments that can slow the progression of Huntington's disease but, when we do, measuring the mutant protein in CSF could guide clinical decisions such as the best time to start a treatment,» said Dr Douglas Macdonald at CHDI.

The researchers hope their designed compounds could be used as diagnostics for amyloid diseases and as drugs to treat the diseases or at least slow progression.

As the messenger of genetic information, RNA plays an important regulatory role in cell and tissue development as well as during disease progressioAs the messenger of genetic information, RNA plays an important regulatory role in cell and tissue development as well as during disease progressioas well as during disease progressioas during disease progression.

Health care officials and aid workers attempting to trace the progression of the Ebola virus disease outbreak that has claimed more than 2,800 lives so far (pdf) have come to rely heavily on a handful of disease - monitoring Web sites that act as pivotal hubs for processing information.

However, in several chronic human diseases such as inflammatory bowel disease (IBD), HIV / AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression.

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

The research goal, as we are putting it out there today, is to develop an effective treatment strategy, delay the onset and slow the progression of the disease.

At the moment, the only treatments are drugs such as interferon beta - 1a and glatiramer acetate (Copaxone), both of which merely slow the progression of the disease.

Clinicians have long noted that the presence of tremors, rather than balance and walking problems, as the initial or dominant symptom of Parkinson's may suggest slower progression of the disease.

Because most cases of Parkinson's disease appear to be at least partially caused by environmental factors such as pesticide exposure, these findings support the approach that targeting α - synuclein could slow or stop the progression of Parkinson's in most people with the disease, said study lead author Jeff Bronstein, a professor of neurology and director of movement disorders at the David Geffen School of Medicine at UCLA.

Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.

As a new generation of gene therapy clinical trials shows promise to cure or halt the progression of several rare diseases, the time has come to explore ways to pay for the cutting edge treatments, a pediatric hematologist - oncologist from Dana - Farber / Boston Children's Cancer and Blood Disorders Center argues in a commentary published by the journal Science.

Brasselet said that the new technique could be used in the near future to better understand progression in diseases that involve a breakdown of the myelin sheath, such as Alzheimer's and multiple sclerosis.

Second, fibrosis is a marker of progression to chronic kidney disease, suggesting that the paracrine effects could act as preventative therapy for other serious ailments.

The study is important because it links diet to changes in the gut microbiota as well as bile acid profile, opening the possibility that probiotics and bile acid receptor agonists may be useful for the prevention and treatment of hepatic inflammation and progression into advanced liver diseases such as cancer.

The research reveals events that may be harnessed for prevention, as well as to slow down progression of retinal degenerative diseases.

By introducing disease related mutations to the cells, researchers could study the onset and progression of the disease and gain new insights into the disease as well as screen and discover new treatment drugs.

As with childhood type 1 diabetes, we can forecast the progression of the disease and adapt the therapeutic measures accordingly,» lead investigator Achenbach explains.