Sentences with phrase «as drug candidates»

Working in the laboratory of John Tainer, Daniels solved the structure of AGT alone and in complex with two inhibitors that were in early development as drug candidates for combating resistance.

I read, with fascination, your article on venoms as drug candidates (5 May, p 34).

«Our ambition is to simplify drug discovery — by using the cell's own metabolites as drug candidates,» Dalby says.

Not exact matches

Topics included: early reporting on inaccuracies in the articles of The New York Times's Judith Miller that built support for the invasion of Iraq; the media campaign to destroy UN chief Kofi Annan and undermine confidence in multilateral solutions; revelations by George Bush's biographer that as far back as 1999 then - presidential candidate Bush already spoke of wanting to invade Iraq; the real reason Bush was grounded during his National Guard days — as recounted by the widow of the pilot who replaced him; an article published throughout the world that highlighted the West's lack of resolve to seriously pursue the genocidal fugitive Bosnian Serb leader Radovan Karadzic, responsible for the largest number of European civilian deaths since World War II; several investigations of allegations by former members concerning the practices of Scientology; corruption in the leadership of the nation's largest police union; a well - connected humanitarian relief organization operating as a cover for unauthorized US covert intervention abroad; detailed evidence that a powerful congressional critic of Bill Clinton and Al Gore for financial irregularities and personal improprieties had his own track record of far more serious transgressions; a look at the practices and values of top Democratic operative and the clients they represent when out of power in Washington; the murky international interests that fueled both George W. Bush's and Hillary Clinton's presidential campaigns; the efficacy of various proposed solutions to the failed war on drugs; the poor - quality televised news program for teens (with lots of advertising) that has quietly seeped into many of America's public schools; an early exploration of deceptive practices by the credit card industry; a study of ecosystem destruction in Irian Jaya, one of the world's last substantial rain forests.

As a PhD candidate at Weill Cornell Medical School, Piraye Beim spent much of her time trying to figure out why a particular cancer drug was lifesaving for some patients but useless — or worse — for most.

«We look forward to working with the SiteOne team as they advance these drug candidates to clinical trials.»

That's particularly unfortuante for Cerecor seeing as CERC - 501 is the company's lead drug candidate — and the news comes just days after Cerecor announced that a separate experimental depression drug called CERC - 301 had also failed in the clinic.

Key findings presented at AACR included sustained peripheral NK and T cell expansion, doses were well - tolerated and the drug candidate's role as a long - acting CD122 agonist without targeting CD25.

There is considerable skepticism among investors about whether this drug candidate will actually work, and as a result, 5 million Medico shares have been sold short of its 25 million shares outstanding.

When the results are announced, they indicate that Medico's drug candidate works better than expected as a treatment for skin cancer.

As an example, consider a hypothetical biotech company, Medico, that has a drug candidate in advanced clinical trials as a treatment for skin canceAs an example, consider a hypothetical biotech company, Medico, that has a drug candidate in advanced clinical trials as a treatment for skin canceas a treatment for skin cancer.

Kirill has challenged the Church to see all segments of Russian society — from bikers to rock music fans, from drug addicts to political candidates — as its mission field.

But the AG contenders aren't the only primary candidates using drug law reform as a campaign platform.

But Greene insisted he has a «zero tolerance policy» for drugs on the boat, and Tyson said he never did anything while aboard the 145 - foot luxury yacht that the candidate refers to as a second home.

Gov. Andrew Cuomo today dismissed Republican presidential candidate — and fellow Queens native — Donald Trump «s calls for a wall along the Mexican border to prevent rapists and drug - dealers from flooding the country as «offensive and low,» and contrary to New York's immigrant history.

Since the drug offender thing is effectively «a wash» in this Dem primary, LBGT donors might as well support the candidate who's less homophobic.

With the absence of any candidate of color in the AG's race, Schneiderman has been trying to position himself as the clear choice for Latino and black voters, stressing in particular his efforts on behalf of Rockefeller Drug Law reform and sponsorship of a controversial measure that will count prisoners at their last address for the purposes of legislative redistricting and not whever they're incarcerated.

Earlier this month, the gubernatorial candidate said that communities of color hard hit by the war on drugs should get first crack at legalized pot as a «form of reparations.»

In candidate forums and interviews, on her campaign Web site and through a campaign spokesman, Ms. Rice has described herself as a strong supporter of changing the Rockefeller - era laws, which bound judges to sentence even nonviolent, first - time drug offenders to prison.

He first won his seat for Labour in the 1997 general election, having contested the predecessor Littleborough and Saddleworth seat at a by - election in 1995, [7] which was marked by Labour's particularly vicious and personal campaign, attacking the Liberal Democrat candidate, Chris Davies, as «high on tax and soft on drugs».

Thomas Ravenel — a reality TV star and former Republican state treasurer who was forced to resign from office after being indicted on federal drug charges — announced Friday that he would run as an independent candidate against GOP Sen. Lindsey Graham.

«It's time to free the prisoners of the war on drugs,» declared Green Party governor candidate Howie Hawkins as he and the party's attorney general candidate and Bronx - based people's lawyer Ramon Jimenez spoke in front of Manhattan Criminal Court.

Aubry said he believes he is the best candidate because of his significant experience in Albany and the major legislation he has passed in that time, such as the reform of the Rockefeller drug laws and sponsoring the United States Tennis Association's National Tennis Center in Flushing Meadows Corona Park.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Overall, this SMA candidate drug is an exciting time as we take another step forward towards developing therapies for SMA patients.»

The three remaining drug candidates that target amyloid - β are currently being tested in people with Alzheimer's, as well as in individuals who have a high risk of developing the disease but who have not yet developed symptoms.

Already, at least one related drug from AstraZeneca is being evaluated in clinical trials as a candidate for treating autistic behaviors.

A pharmaceutical hit compound, like those discovered by Vogel and her co-authors, is a compound that is a promising candidate for chemical modification so it can eventually be delivered to patients as a therapeutic drug.

Alzheimer's is a disease for which there are still no treatments that fundamentally alter the course of the disease, as trial after trial of drug candidates have ended in failure.

As Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druAs Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druas a reliable biomarker in personalised medicine to select the best suited candidates to receive this drug.

The biopharmaceutical industry will also increase its spending as it moves new drug candidates into development and clinical trials.

Dr O'Neill concludes: «Our findings underscore the importance of revisiting unexploited antibiotics as a potential source of new antibiotic drug candidates.

Scientists characterize the advance as a game changer that could dramatically accelerate the testing of new drug candidates.

I've described interacting molecules as dancers and new drug candidates as debutants.

However, CiRA researchers from Professor Junya Tochuchda's lab instead looked at molecules related with inflammation, finding Activin - A as a candidate drug target.

The mutation would also serve as a strong candidate for drug development.

Li Ying's group in Shanghai synthesized artemisinin derivatives that were more potent at killing malaria parasites and had more desirable chemical properties (such as solubility in water), making them better drug candidates than natural artemisinin.

His team looked at an experimental drug called PTC124, which the firefly luciferase assay had identified as a promising candidate for treating stop - sign forms of cystic fibrosis and which is now being tested in clinical trials.

«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

The result is a new dual - targeting drug candidate — or, as Griffin describes, «one drug addressing multiple therapeutic indications» — that could treat both diabetes and bone disease.

Shah and Shpall's team enrolled symptomatic patients who qualified as candidates for high - dose chemotherapy drugs like melphalan, and transplantation of the patient's own stem cells.

Robotized «high - throughput screens» like this are a growing trend in drug development as they can work through massive libraries of candidate drugs quickly and accurately in a day, as opposed to the months required by manual methods.

«The advanced nano - focussed x-ray beam at ESRF has not only allowed us to locate the site of action of our novel Organo - Osmium FY26 candidate drug in cancer cells at unprecedented resolution, but also study the movement of natural metals such as zinc and calcium in cells.

Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.

Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.

«Nothing is a miracle cure,» Carraher warns, but this polymer - cephalexin elixir may be a «candidate as a last - defense cancer drug.»

The work adds to a pipeline of molecular clinical and pre-clinical drug candidates for the treatment of oxidative stress and serves as a good starting point for researchers to find similar compounds, Hannink said.

Conveniently, this cooler temperature acts as a corrector helping more proteins with the Delta F508 mutation to reach the surface, where they encounter the candidate doorman drug.

«This was exciting, as we now have a much clearer idea of how our drug candidate is working.»