Sentences with phrase «as drug resistance»

These include issues such as drug resistance and other cross-border health risks, financial crises contagion, money laundering, water scarcity, fisheries collapse and, of course, climate change.

Drs. Baughn and Minato hope that the understanding of mechanisms for synergy will lead them and others to more potent drug combinations that can be deployed in the fight against pathogenic microbes as drug resistance becomes increasingly commonplace.

«As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline.»

Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.

Not exact matches

Such concern has sparked the launch of the Obama administration's five - year plan to combat antibiotic resistance, as well as the Food and Drug Administration's new guidelines aiming to restrict antibiotic use in farm animal products, like meat and poultry, that make it to our dinner plates.

Treating malaria with chloroquine is no longer a viable option for most people as the parasite has developed resistance to the drug.

The School Resource Officers or SRO's will begin working in the Lake Shore and Silver Creek School District's, mentoring and teaching K - 12 students about topics such as anti-bullying and drug resistance.

As a result, Soviet pharmaceutical companies churned out billions of units of questionable drugs that were only partially effective at normal dosages, weakening bacteria but not killing them outright — an environment perfect for spurring antibiotic resistance.

If so, and if researchers can identify the exact sugars responsible, those molecules might be converted into desperately needed new antibiotic drugs that could sidestep some of the problems, such as bacterial resistance, with existing antibiotics.

As a result, P - gp causes resistance of the diseased cells to a majority of drugs currently available for the treatment of cancer, as well as drugs used for treatment of infectious diseases like HIV / AIDAs a result, P - gp causes resistance of the diseased cells to a majority of drugs currently available for the treatment of cancer, as well as drugs used for treatment of infectious diseases like HIV / AIDas well as drugs used for treatment of infectious diseases like HIV / AIDas drugs used for treatment of infectious diseases like HIV / AIDS.

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.

The conventional idea is that susceptible bugs perish, leaving behind a few individuals whose drug resistance is passed on as they multiply.

«As part of the strategy to combat the antibiotic resistance crisis, we should think about strategies to use less drugs and use drugs for shorter duration.»

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

However, the BCG vaccine was developed 86 years ago, and TB, with increasing drug resistance, now kills more than 1.5 million people each year, second only to HIV / AIDS as the world's most deadly infectious disease.

The researchers found that the gene conferring drug resistance has spread among bacteria in China, where colistin is widely fed to livestock as a prophylactic.

Hence, both of the drugs could serve as alternatives for treating CML — especially in patients who have developed a resistance to the medication they have been receiving so far.

Drug resistance is a major problem in cancer treatment, as drug resistant cancers are thought to be the primary cause of cancer relaDrug resistance is a major problem in cancer treatment, as drug resistant cancers are thought to be the primary cause of cancer reladrug resistant cancers are thought to be the primary cause of cancer relapse.

«We've also started exchanging ideas and information with scientists facing related challenges, such as resistance to herbicides in weeds and resistance to drugs in cancer cells,» Tabashnik said.

The bacterium developed resistance to the traditional drugs in as little as three days.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

To keep resistance from developing as fast as the new drugs are produced, some may not be sold at all until they are absolutely needed, says Outterson.

The common pathway found in mouse models was also found in human tumors, suggesting that resistance could indeed be blocked in patients with the same drug as in mice.

The strategy was containment: Build a firewall around areas of drug resistance by ramping up control measures, such as bednets, rapid diagnostic tests, and ACTs.

He says it's also important to understand the protein's biological role in cellular signaling and normal animal development as well as to consolidate its role in human cancer development, progression and drug - resistance.

Treatment failure may have occurred because participants either did not take their antiretroviral drugs as prescribed or had an HIV strain that resisted or acquired resistance to one or more of the drugs in their treatment regimen.

Seasonal flu strains such as H1N1 and H3N2 have shown little resistance to the drug in adults, but two small studies have shown resistance rates of up to 18 % in Japanese children (ScienceNOW, 26 August 2004).

Just as chemotherapy often requires several drugs to combat resistance in cancerous cells, successful antimicrobial therapy against some pathogens requires a combination of drugs.

The World Health Organization General Assembly recently named drug resistance in microbes as one of the top three threats to global health.

Preventative treatment of malaria is a useful strategy to protect young children in Africa, but it is unclear which drug and dosing strategy is most effective, especially with the rise of resistance to a class of drug known as antifolates, such as sulfadoxine - pyrimethamine (SP) and trimethoprim - sulfamethoxozole (TS).

It would receive $ 8.7 million to extend its review of antibacterial drugs and oversight of antibiotics in livestock as part of the Combating Antibiotic - Resistant Bacteria (CARB) initiative, a national strategy that has prompted Congress to nearly double overall spending on antibiotic resistance across several agencies, to $ 774 million in 2016.

We've already moved away from using quinine to treat cases as the malaria parasite has become more resistant to it, but if further drug resistance were to develop against our most valuable malaria drug, artemisinin, we would be facing a grave situation.

The current results, however, may not hold true in all areas because risk of malaria transmission varies according to location, as does parasite resistance to drugs.

Reducing inflammation with a drug such as celecoxib «reverses treatment resistance and enhances overall antidepressant response,» Dr. Halaris wrote in the study.

Until RDTs became widespread, almost all fevers were treated as if they were malaria, leading to the overuse of the new generation of «wonder drugs,» artemisinin - based combination therapies (ACTs), which were in danger of being lost to drug resistance.

The need for new antiflu drugs is increasingly urgent, as several recent flu strains, including the swine flu, have developed resistance to currently available treatments such as Tamiflu.

Human mobility is expected to continue to rise, creating a range of impacts, such as invasive species, drug resistance spread and disease pandemics.

Cancer stem cells can be considered the most dangerous type of cancer cells, as they appear to have an inherent resistance to the chemotherapeutic drugs used today.

It shows that new drugs which are introduced to circumvent known resistance mechanisms, as methicillin was in 1959, can be rendered ineffective by unrecognized, pre-existing adaptations in the bacterial population.

That's because gut phage from mice treated with one drug carried high levels of genes that confer resistance to different drugs, which means that the phage could serve as backup when bacteria must find ways to withstand a variety of antibiotics.

A new study led by University of Kentucky researchers suggests a new approach to develop highly - potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.

Looking for drugs that target interactions between a virus and host, such as these proteins involved in budding, reduces the likelihood that a virus would mutate to develop resistance, which is an advantage of this strategy, Harty said.

Refugia represent a management strategy that's being considered as a way to slow down the development of drug resistance, particularly in animal health.»

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

As a clinician - scientist with a translational research focus, Dr. Deininger is heading an extramurally funded research laboratory that is dedicated to the study of signaling pathways, drug resistance, and new molecular therapies in leukemia.

Antibiotics are unique among drugs as the more they are used, the less effective they become and over time resistance develops.

The strategy would take advantage of parasite refugia — host populations that have not been treated with drugs, thereby serving as «safe zones» where parasites don't develop drug resistance.

The drug, originally developed to treat hypertension in adults, works in pulmonary hypertension newborns by reducing pulmonary vascular resistance, relaxing the lungs and keeping the heart from having to work as hard.

and drug resistance is taken as evidence that we don't need to invoke climate change,» she added.

Instead, many people end up with less expensive but ineffective drugs such as chloroquine and artemisinin monotherapies, which increase the risk of drug resistance.