Sentences with phrase «as early biomarkers»

Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington's disease

Several large - scale, federally funded epidemiological studies are under way to pinpoint possible environmental triggers, as well as early biomarkers of autism.

«This confirms that while unique to each individual, some aspects of the family connectome are inherited and maintained throughout development and may be useful as early biomarkers of mental or neurological conditions,» said lead author Oscar Miranda - Dominguez, Ph.D., research assistant professor of behavioral neuroscience, OHSU School of Medicine.

Accordingly, the currently identified miRNA - like fragment may function as an early biomarker of EVD to advance the diagnosable window and reduce the difficulties in the isolation and treatment of patients who develop suspicious symptoms.

Not exact matches

Support a multi-year effort led by world - class scientists to develop a blood test for earlier detection of breast cancer when survival rates are the highest, known as the EIF Breast Cancer Biomarker Discovery Project.

Intake of rice early in childhood has not been well characterized in the United States, and there are only limited data from other regions of the world.5, 6 Moreover, biomarker concentrations of As among infants consuming rice are virtually unknown.

Recently, DNA shed from tumor cells has been identified as a noninvasive method of screening biomarkers for the early diagnosis and prognosis of cancer.

«Targeting multiple biomarkers could potentially allow us to identify prostate cancer at its early stages as well as after metastasis in one scan.»

«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.

This year the findings are published in Cancer Epidemiology, Biomarkers & Prevention as well as in a standalone consumer publication Cancer Prevention & Early Detection Facts & Figures.

Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.

This abnormality specific to autistic children may therefore constitute a biomarker for the disease that could enable their earlier diagnosis and management, as from the age of two years.

However, in the early stages of disease these «biomarkers» can be difficult to detect, as they are relatively rare.

Detecting important biomarkers in lower concentrations will allow patients to be treated earlier for diseases such as some cancers and neurological disorders, which could increase the chance of survival rate.

By the early 2000s, multi-stakeholder collaborations proliferated to address the need for important tools, such as biomarkers, that require preclinical data sharing.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

New protein biomarkers would ideally show specific brain pathologies and act as early indicators of disease.

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

If the findings hold up across different autoimmune diseases, it's possible that the characteristic patterns of Xist localization could be used as a disease biomarker, enabling earlier diagnoses and treatment.

«This research could help us find biomarkers for early detection, as well as provide information for developing targeted therapies for this devastating disease.»

These results not only suggest early mitochondrial biogenesis deficits as a pathogenic mechanism, but also as a potential biomarker and therapeutic target in individuals with Friedreich's ataxia.

The majority of evidence fell into three categories: biological indicators or biomarkers, such as leukocyte telomere length (LTL), earlier occurrence or higher prevalence of medical conditions associated with advanced age and premature mortality.

Kana's multimodal neuroimaging - based classification is a step toward a possible biomarker for autism and possibly diagnosing autism at an early age, perhaps as early as 6 months, when the brain is very plastic and intervention might be more effective.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

Their new study points to a biomarker in the cellular machinery that could not only serve as an early warning of colon cancer, but potentially be harnessed to counteract advanced forms of the disease, the second - largest cause of cancer death in the U.S.

Exosomes and exomeres are also detectable in bodily fluids such as lymphatic fluid, which might allow development of biomarkers for early detection of cancer or other pathological conditions.

DNA shed from tumour cells has been identified as a non-invasive method of screening biomarkers for the early diagnosis and prognosis of cancer

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

In addition to her expert skill as a clinician, Dr. Frontera also has many research interests including identifying biomarkers and predictors of early brain injury and vasospasm / delayed cerebral ischemia after subarachnoid hemorrhage and their impact on outcome; determining the efficacy of therapeutic strategies and developing guidelines for the management of patients with intracranial hemorrhage; evaluating the cost, length of stay, quality of life, functional and cognitive outcomes in a broader population of intracranial hemorrhage patients; developing guidelines for the integration of palliative care into the intensive care unit setting; and evaluating the relationship of Zika virus infection, Guillain - Barre, and other neurologic disorders.

Recent studies showed that optic nerve damage in glaucoma triggers the production of autoantibodies, which could be used as biomarkers to glaucoma early detection.

With further research, the team says the concept could be adapted to monitor other biomarkers besides calcium, to serve as early warning systems for other gradually - developing illnesses like neurodegenerative diseases and hormonal disorders.

Recently, DNA shed from tumour cells has been identified as a non-invasive method of screening biomarkers for the early diagnosis and prognosis of cancer.

These biomarkers can then be applied in glaucoma suspects or glaucoma patients to detect disease earlier as well as to detect progression much earlier at a stage where it can be prevented through appropriate treatments.

«This is a really interesting result, and suggests that we might someday be able to use splicing as a kind of biomarker or early signature of aging,» says Heintz.

This may be associated with sex hormones and their receptors, different body fat distribution and related biomarkers, such as higher adiponectin, which are discussed earlier.

«Since NEC progresses so rapidly and the symptoms develop suddenly, a non-invasive biomarker that allows early detection of patients at risk is required as a matter of urgency.»

We're using this advanced biomarker imaging endpoints as part of our way to detect whether the therapeutic is having a positive effect early in the trial.

A new plasmonic sensor developed by researchers at the University of Illinois at Urbana - Champaign will serve as a reliable early detection of biomarkers for many forms of cancer and eventual... Read more

It's potential as a biomarker of disease and an early objective marker of treatment response is genuine but still to be realized.Resting - state functional magnetic resonance imaging has made some strides in the clinical realm but significant advances are required before it can be used in a meaningful way at the single - patient level.

Identify circulating miRNAs that are altered in early AD, and could ultimately and reliably be used as biomarkers to monitor pathological changes in AD patients.

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

several of the most recently discovered biomarkers and how they can be used as early warnings of chronic disease, sometimes years before the disease actually manifests.