Sentences with phrase «as effector»

Besides their well - known function as effector cells in allergic responses, mast cells were reported to play a critical role in innate immunity and to exert important stimulatory but also suppressive functions in adaptive immune responses.

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

However, unlike the BALB / c model, immunization in B6 mice results in a qualitative difference, with prominence of other cytokines in addition to IFN - γ and specifically with TNF - α gaining a pathogenic role as an effector cytokine.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The most potent of these, known as effector memory T cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of endothelial cells lining the donated organ's blood vessels.

The in vitro boosted effector cells were washed once with HBSS and then resuspended in CRPMI and used as effector cells in the cytotoxicity and apoptosis assays (below).

These are led by activated T helper 2 (TH2) cells and type 2 innate lymphoid cells (ILC2s), together known as effector cells.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

In examining individual meal components, we identified volume, protein, and salt as effectors of postprandial sleep.

Not exact matches

«Before CRISPR, there was TALENS [transcription activator - like effector nucleases] and zinc finger nucleases — older technologies that were not as precise or reliable,» explains Sosa.

Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach using this and older gene editing technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.

We suspect that this «junk» HIV can act as a decoy and draw attention away from the «real» virus hiding in the effector memory T - cells,» she said.

Although the study looked at CRISPR - Cas9 gene editing, the researchers believe their findings extend to other gene - editing tools such as zinc - finger nucleases (ZFN) and TAL effector nucleases.

As the end products and biological effectors of gene expression, proteins are crucial for improving our understanding of human biology, developing new and better drugs, and advancing precision medicine.

«It was once believed that effector and memory cells arose as two distinct populations, with some cells initially fated to be effector type and some to be memory,» McDonald said.

As the interleukin - 2 levels drop, effector cells can turn on a protein called Bcl - 6.

Effector T cells incite GvHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells.

The «kick - and - kill» paradigm is aimed at combining latency reversing agents (LRA) with immune effectors, such as T - cells, to wake up the virus and kill the reactivated cells.

This study shows how exhausted T cells do not maintain a durable switch to an effector T cell profile, although in the clinic, checkpoint inhibitors are well tolerated and their side effects such as autoimmunity are usually manageable.

As well as innovative tools for basic research, CRISPR - associated effector complexes will be instrumental for developing the next generation of antiviral prophylactics and therapeuticAs well as innovative tools for basic research, CRISPR - associated effector complexes will be instrumental for developing the next generation of antiviral prophylactics and therapeuticas innovative tools for basic research, CRISPR - associated effector complexes will be instrumental for developing the next generation of antiviral prophylactics and therapeutics.

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

The things that we have demonstrated — such as the fact that the vertical nanowires can deliver any biological effector to any cell type in a spatially selected fashion — have drawn interest from many different people, and we have been working with stem cell institutes and others to demonstrate the unique utility of this particular platform.

Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

PKA and actin play critical roles as downstream effectors in MRP4 - mediated regulation of fibroblast migration.

Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.

Among the multiple p53 transcriptional targets, p21 stands out as the main, although not exclusive, effector of p53 - mediated cell cycle arrest (8, 9, 10).

As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome - wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

When considering the anatomy of the mucosal immune system, sites can be defined as either inductive or effector sites.

Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).

The «HIF - 1 signaling pathway» also activates Glycolysis through the activation of different circuits that trigger effector proteins (PDK1, PFKL, ALDOA, etc.) with annotations such as glycolytic process, canonical glycolysis, glucose metabolic process, etc..

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

[13] Effector sites include areas such as the lamina propria, exocrine gland stroma, and surface epithelia, where mature lymphocytes perform their functions, such as releasing cytokines and secreting antibodies.

Activation of multiple signaling pathways may allow cells to finely tune expression of effector molecules as well as provide redundancy and resiliency.

Antibodies are key effector molecules in health and disease as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses.

Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].

We identify several other effector types as well (Table S1), including 14 members of the prophenoloxidase cascade, two lysozymes, 3 transferrins, and 18 peroxidases.

The innate immune system is particularly amenable to characterization with expression - based methodology such as RNA - seq, as one of the key biological consequences of pathogenic infections is the rapid induction of several classes of effector proteins, along with up - regulation of a number of other pathway components.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

Immune effector systems also consist largely of metazoan innovations, such as the macrophage - expressed gene 1 (MPEG1) that participates directly in pathogen elimination38.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

One of the ways that effector molecules are secreted is through extracellular vesicles (EVs) such as exosomes.

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.

Here, we identify Itpkb as a novel pre-TCR effector which restricts the kinetics of β - selection and establishes its Notch - dependence.

I've found an artificial vanillin with exactly the same information Mark added about vanillin toxicity, in the link below: http://www.viacheminc.com/wp-content/uploads/MSDS-Eternal-Pearl-Brand-Vanillin-and-Ethyl-Vanillin.pdf It says «Oral rat LD50: 1580 mg / kg Investigated as a mutagen, reproductive effector.»

One can also entertain the interesting possibility that, in skeletal muscle, this substrate cycling is also activated in response to other hormones and neurotransmitters (eg, adiponectin, catecholamines) particularly since adiponectin, as well as adrenergic agonists, can also stimulate AMPK activity, glucose utilization and fatty acid oxidation in skeletal muscle or adipose tissue.61, 66 — 69 This substrate cycling between de novo lipogenesis and lipid oxidation could therefore constitute a thermogenic effector in skeletal muscle.