Sentences with phrase «as effector cells»

Besides their well - known function as effector cells in allergic responses, mast cells were reported to play a critical role in innate immunity and to exert important stimulatory but also suppressive functions in adaptive immune responses.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The in vitro boosted effector cells were washed once with HBSS and then resuspended in CRPMI and used as effector cells in the cytotoxicity and apoptosis assays (below).

These are led by activated T helper 2 (TH2) cells and type 2 innate lymphoid cells (ILC2s), together known as effector cells.

Not exact matches

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

We suspect that this «junk» HIV can act as a decoy and draw attention away from the «real» virus hiding in the effector memory T - cells,» she said.

«It was once believed that effector and memory cells arose as two distinct populations, with some cells initially fated to be effector type and some to be memory,» McDonald said.

As the interleukin - 2 levels drop, effector cells can turn on a protein called Bcl - 6.

Effector T cells incite GvHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells.

The «kick - and - kill» paradigm is aimed at combining latency reversing agents (LRA) with immune effectors, such as T - cells, to wake up the virus and kill the reactivated cells.

This study shows how exhausted T cells do not maintain a durable switch to an effector T cell profile, although in the clinic, checkpoint inhibitors are well tolerated and their side effects such as autoimmunity are usually manageable.

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

The things that we have demonstrated — such as the fact that the vertical nanowires can deliver any biological effector to any cell type in a spatially selected fashion — have drawn interest from many different people, and we have been working with stem cell institutes and others to demonstrate the unique utility of this particular platform.

Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Among the multiple p53 transcriptional targets, p21 stands out as the main, although not exclusive, effector of p53 - mediated cell cycle arrest (8, 9, 10).

The most potent of these, known as effector memory T cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of endothelial cells lining the donated organ's blood vessels.

Activation of multiple signaling pathways may allow cells to finely tune expression of effector molecules as well as provide redundancy and resiliency.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.