Sentences with phrase «as efflux»

Not exact matches

Bacterial efflux pumps, such as the P. aeruginosa MexAB - OprM pump shown here, are one of the dominant molecular mechanisms available to Gram - negative pathogens for removing toxins, including antibiotics.

For this study, the researchers focused on efflux pumps inside the bacteria Pseudomonas aeruginosa, which can cause serious illnesses such as pneumonia and sepsis.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

The team focused on one efflux pump protein, known as AcrA, which connects two other proteins in a tunnel shape through the bacterial cell envelope.

«As a first in this field, we proposed the approach of essentially «screwing up» the efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular BiophysicAs a first in this field, we proposed the approach of essentially «screwing up» the efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysicas a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysics.

The TB bacteria use efflux pumps as a strategy to remove drugs and other threats from the cell before they can work against the bacteria.

A, The expression of several ABC efflux transporters, including Abcb1a, Abcb9, Abcc5, and Abcc10, were significantly up - regulated in testes after long - term drug treatment as compared with the control.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

Ceruloplasmin has been proposed as an important factor in cellular iron efflux and has been suggested to be downregulated in atherosclerotic plaques.3 Ceruloplasmin functions as an antioxidant.

Ceruloplasmin has been proposed as an important factor in cellular iron efflux and has been suggested to be downregulated in atherosclerotic plaques.

An effect of walnuts on ex vivo cholesterol efflux was observed with whole serum but not apoB - depleted serum; in addition to HDL, LDL can serve as an acceptor of free cholesterol in the reverse cholesterol transport pathway (39), indicating that walnuts may have a greater effect on global cholesterol efflux than HDL - specific efflux.

Finally, cholesterol efflux was quantified only in the whole walnut group as an exploratory analysis, which precluded comparison among treatments.

As we discover that influxes, and thus effluxes, are far higher than had been assumed, the less long term the perturbation of the system is imposed by human generated CO2.

As atmospheric levels of He are low, the efflux must be relatively rapid.

You would be surprised how often overall flux is stated as «true» even in cases where influx and efflux are not known.

The fit has a correlation coefficient of 0.997; but in reality sucks as my model assumes that CO2 efflux is first order with respect to CO2, where in fact it is probably closer to second order.

Keep it constant, and the shell never warms to the same as the initial temp., of the earth, and the earth warms only slightly because the presence of the shell slows down the efflux of heat (it's an insulator).