Some cytochrome p450 enzymes act on polyunsaturated fatty acids to make cellular signaling molecules known
as eicosanoids.
This particular enzyme produces arachidonic acids from the membrane, which is then transformed into prostaglandins, plus other compounds known
as eicosanoids which have a contributing role in the degradative processes.
At a mechanistic level, curcumin mitigates inflammation by inhibiting an array of pro-inflammatory signaling molecules, such
as the eicosanoids known as leukotrienes, thromboxanes, and prostaglandins, which elicit deleterious effects ranging from pain to blood clotting to airway constriction (Chainani, 2003).
Not exact matches
These molecules include
eicosanoids prostaglandin E2, leukotriene B4 and thromboxane TXB2, second messengers cAMP and cGMP,
as well
as bile acids, conjugated steroids, and folic acid.
The specific anti-inflammatory chemicals
eicosanoids, mentioned above, have similar effects to aspirin, but without downsides such
as gastric bleeding.
These fatty acids are converted to
eicosanoids such
as prostaglandins and leukotrienes.
As I illustrated above, arachidonic acid is processed by the enzyme cyclooxygenase (COX) to produce pro-inflammatory signaling molecules called
eicosanoids, including leukotrienes, prostaglandins, and thromboxanes.
When incorporated into the cell membranes of the body, these omega - 3 and omega - 6 fatty acids function
as precursors for
eicosanoids that control a host of cellular functions and responses.
A lack of efforts to reduce inflammation in the body can contribute chronic Western disease, such
as heart disease and cancer Omega - 3 fatty acids have proven to reduce the production of molecules and substances linked to inflammation, such
as inflammatory
eicosanoids and cytokines Studies have consistently shown a link between higher omega - 3 intake and reduced inflammation.
As I mentioned above, Omega 3's and Omega 6's «compete» in the body for the enzymes that convert them into the signal molecules
eicosanoids.
If we can alter our diet to favor Omega 3 metabolism, we will have less
eicosanoids from Omega 6's and
as a result, lower systemic inflammation.
Using turmeric to slow the body's production of
eicosanoids brings their levels in the body back to normal levels and
as a result, chronic systemic inflammation in the body decreases significantly.
It must depend how the oxidation is being generated
as well eg mitochondrial type energy processes, or chemical reaction like
eicosanoid production, and where if at all do the two meet.