A variety of receptors are internalized into the cell through a process known
as endocytosis.
Methods: Researchers Harish Shankaran, Haluk Resat and Wiley paired a new module - based systems theory approach with quantitative metrics for network function to show that receptor / ligand properties such
as endocytosis can be described by just a few control parameters.
Consequently, many cellular processes such
as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.
Not exact matches
She still runs an eight - person lab, studying
endocytosis with four grad students who probably don't have to attend
as many lab meetings
as they used to.
These findings provide a previously unrecognized mechanism for receptor recruitment of β - arrestin and demonstrate that Dvl plays an important role in the
endocytosis of frizzled,
as well
as in promoting signaling.
The TPLATE complex turned out to be key for plant
endocytosis as it arrives first at the position where
endocytosis should get initiated.
While proteins involved in
endocytosis, such
as clathrin, are conserved across the animal and plant kingdoms, the members of the TPLATE complex appears specially designed for plants.
Endocytosis is a fundamental membrane trafficking process by which cells uptake external factors such
as proteins and pathogens.
In particular, this study demonstrates the capability to track structural dynamics and remodeling of the cell surface, such
as morphogenesis of filopodia, membrane ruffles, pit formation or
endocytosis, in response to environmental stimulants.
As all yeast integral PM components that we observed exhibit very slow lateral mobility we expect that delivery and removal of membrane components via exo - and
endocytosis have a major influence on the final lateral localization patterns.
The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts
as a driving force for membrane invagination in clathrin - independent
endocytosis.
Endocytosis has traditionally been viewed
as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.
This rather simplistic view is now changing with emerging evidence that
endocytosis is an integral component of the cell signalling machinery, regulating aspects such
as the duration, intensity, integration and spatial distribution of signals.