Neurotransmitter studies of monoamines (dopamine, serotonin, epinephrine and norepinephrine), acetylcholine, glutamate and gamma - aminobutyric acid (GABA) were reviewed, as well as neuromodulators such
as endogenous opioids and endocannabinoids.
Beta endorphins ease emotional and physical pain and are in a class of neurotransmitters known
as endogenous opioid's.
Not exact matches
Using a small amount of a radioactive substance
as a tracer, the scientists focused on the brain's mu -
opioid system in which chemicals called
endogenous opioids bind to receptors and hinder the spread of pain messages in the brain.
There are four broad classes of
opioids:
endogenous opioid peptides, produced in the body; opium alkaloids, such
as morphine (the prototypical
opioid) and codeine; semi-synthetic
opioids such
as heroin and oxycodone; and fully synthetic
opioids such
as pethidine and methadone that have structures unrelated to the opium alkaloids.
Looking at previous work on other addictions, such
as alcoholism, we anticipated that pathological gamblers would have increased opiate receptors which we did not find, but we did find the expected blunted change in
endogenous opioids from an amphetamine challenge.
The body also synthesizes
endogenous opioids, known
as endorphins, which bind to the same receptors and have the same analgesic effects
as morphine.
Endogenous opioids, such
as endorphin and dynorphin, are natural chemicals, related to the opium molecule, that are produced in the central nervous system.
The mechanisms by which low - level laser therapy (LLLT) decreases pain include release of
endogenous opioids, changes in conduction latencies of nerves, increased cellular metabolism, increased circulation, promotion of neovascularization, decreased fibrosis formation, and reduction of inflammation.30 Feline conditions that respond well to LLLT include osteoarthritis, degenerative lumbosacral stenosis, fractures, chronic wounds, and stomatitis.31 Most cats tolerate LLLT well,
as it is not painful and can be delivered in a relatively short time (FIGURE 2).31