Sentences with phrase «as endoplasmic reticulum»

«If we can find molecules that modulate membralin, or identify its role in the cellular protein disposal machinery known as the endoplasmic reticulum - associated degradation (ERAD) system, this may put the brakes on neurodegeneration.»

Not exact matches

A protein was engineered so that it accumulated as aggregates in the endoplasmic reticulum.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

This information flow may also be followed through the cell as it travels from the DNA in the nucleus, to the Cytoplasm, to the Ribosomes and the Endoplasmic Reticulum, and finally to the Golgi Apparatus, which may package the final products for export outside the cell.

Transit of a CD8 - p24 chimera from the endoplasmic reticulum through the Golgi complex was slowed when the phenylalanine motif was mutated, suggesting that this motif may function as an anterograde transport signal.

Wolfram syndrome is caused by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.

First, mild endoplasmic reticulum stress and impaired calcium release seriously disturbed mitochondrial dynamics, thus providing an explanation as to why alterations in the endoplasmic reticulum could lead to impaired mitochondrial dynamics.

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum.

«This has been an area of discussion for many years, as to whether there is the possibility of this translocation of ApoE from the secretory pathway, from the ER [endoplasmic reticulum] and the Golgi, where clearly it is predominantly located,» he continued.

Notably, we found «Protein processing in endoplasmic reticulum» and «PI3K - Akt signaling pathway» might be impaired in DACD pathogenesis, while Growth factor receptor - bound protein 2 might be a crucial protein as a molecular target of the neuroprotective effects of ZBPYR.

The corrected paper is a review in the Journal of Virology — known there as a Gem — which discusses how viruses use the membranes of endoplasmic reticulum (ER) to replicate.

Ultra-deep sequencing of resistant parasites identifies the sarco / endoplasmic reticulum Ca (2 +) transporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288.

These sub-cellular mini organs do various functions for the cell such as generate energy (mitochondrion) and remove waste products (lysosomes) and make proteins (endoplasmic reticulum).

Within the cells there are organelles (mini-organs) such as the mitochondrion and endoplasmic reticulum.

One textbook describes the parts of the cell as follows: «Running through the cell is a network of flat channels called the endoplasmic reticulum.