Sentences with phrase «as epidermal»

Blood also carries hormones, such as epidermal growth factor, that determine the growing, resting, regressing, and shedding phases.

In vivo, breast cancer growth is regulated by estrogens and peptide growth factors, such as epidermal growth factor (EGF), the receptor of which has intrinsic PTK activity.

A major challenge for assessing driver mutations, such as epidermal growth factor receptor (EGFR) mutations, in advanced disease is the scarcity of suitable biopsy tissue for molecular testing.

In most adult tissues, cells go about their daily business — absent a command from a growth factor, such as epidermal growth factor (EGF), they don't really need to grow, much less divide.

Preliminary study of a polycaprolactone membrane utilized as epidermal substrate.

The study findings suggest that a hard shell was formed as the result of mutations in a group of genes known as the Epidermal Differentiation Complex (EDC).

Not exact matches

As proof they do not share a common ancestor it is known that in the octopus the eye develops from the epidermal layer then works it's way in to the nervous system.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

Researchers found that a combination of drugs — one targeting epidermal growth factor receptor (EGFR) and one targeting tumor necrosis factor (TNF)-- effectively blocks the cancer from using TNF as an escape route.

Potential adverse side effects include toxicity of the nervous system, kidney and liver, headaches, and rare, but serious skin conditions such as Stevens Johnson syndrome and toxic epidermal necrolysis.

Importantly, the new technique grows the pluripotent stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and epidermal growth factor.

The researchers note urinary epidermal growth factor has the potential to reduce trial costs by as much as 75 percent, as well as shorten the time until a medicine is widely available to all patients.

For example, epidermal growth factor (EGFR) mutations may result in sensitivity to drugs that are EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib or gefitinib, whereas individuals with the EGFR T790M mutation are more resistant to these drugs.

«This raises an interesting issue as to whether serotonin uptake inhibitors, such as cocaine, methamphetamine and other recreational drugs in this category, may act at the epidermal serotonergic synapses to alter tactile sensations.

Wei Long Ng explained: «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such as erlotinib, gefitinib and afatinib.

Alice Shaw recalls a signal moment in 2004 — just as she was finishing her oncology fellowship at MIT — when scientists discovered that mutations in a gene for epidermal growth factor receptor (EGFR) were the culprits in about 10 to 15 percent of lung cancer patients.

As soon as we got it out of the package, she became a diligent young investigator, studying the leg of a fly, dog cardiac muscle and onion epidermal cellAs soon as we got it out of the package, she became a diligent young investigator, studying the leg of a fly, dog cardiac muscle and onion epidermal cellas we got it out of the package, she became a diligent young investigator, studying the leg of a fly, dog cardiac muscle and onion epidermal cells.

Pigs treated with valsartan had a thicker epidermal layer (the outermost layer of the skin) and dermal collagen layer, as well as a more organized collagen fiber arrangement, all of which indicate 1 percent valsartan application leads to stronger healing skin, Abadir says.

We wish to focus on severe drug - induced adverse events, such as Stevens - Johnson syndrome, toxic epidermal necrolysis, and drug - induced liver injury.

Derivation of pluripotent stem cells, either of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for epidermal cell therapy as these cells are both immortal and pluripotent, theoretically capable of providing any requested number of cells of any desired phenotype.

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.

Resident macrophages from the same lineage, such as liver Kupffer cells, brain microglia, epidermal Langerhans cells, lung alveolar macrophages..., display tissue - specific phenotypes, perform tissue - specific functions and have distinct gene expression profiles.

With this technology, they could watch for responses as cancer cells responded to signals from EGFR (epidermal growth factor receptor).

Similarly, lipid containing structures in epidermal cells (K and L) are bigger in wild type animals as shown in the (K) and smaller in mutant animals (L).

Ng explains, «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

Transient assays were done in onion epidermal cells using the plant signal sequence fused to RBP and a GFP reporter (ssRBP - GFP fusion protein) with RBP fused to GFP as a control.

In the majority of studies of in vitro maturation (IVM), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol and epidermal growth factor (EGF) are used as supplements.

For epidermal cells, the last cell before the hair cell was the one measured as lmax.

In addition to RIPK2 binding as part of this computer - based (initial) screening, we selected compounds that inhibited epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously identified RIPK2 inhibitors.

We are using the epidermal growth factor receptor (EGFR) as a model «endocytic system» to address these issues.

In support of this threshold effect, doubling or tripling peel - 1 copy number among male - sired embryos did not produce a more severe phenotype, at least as measured by the onset of epidermal leakage (Figure 5D).

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

Peptide growth factors are constantly present in the gastrointestinal tract, being secreted by glands; for example, Epidermal Growth Factor (EGF) from the salivary glands, or ingested in foodstuffs such as milk and colostrum.

More than 3,000 years of recorded use, as well as modern clinical research in both humans and animals, suggest a wide range of potential applications for BLACK CUMIN SEED OIL ORGANIC - from helping to balance the gut microbiome to benefitting epidermal structure and appearance.

Skin epidermal barrier function is critically important to our skin at any age, and the breakdown of this barrier for any reason causes problems such as rashes, eruptions, dry skin, and poor wound healing.

Together with potassium and sterolins, these nutrients encourage epidermal cell turnover, making the oil ideal for anti-aging products, dry skin formulations and as a treatment for damaged skin cells and a range of skin conditions that include eczema and psoriasis.

Many call this nutrient «an antioxidant that is skin beautifying, being as it is present in the epidermal tissue of humans, this is where the suppleness and smoothness is created,»

However, in one study, where the lipids obtained form the skin of healthy controls and dogs with acne were evaluated, it was found that the lipids obtained from the acne lesions, such as free sterols, fatty acids, and ceramides, are characteristic epidermal lipids and that sebaceous gland contribution is minimal.

Cancer, and a wide variety of types of liver damage, can induce an inflammatory and degenerative condition of the skin known as «metabolic epidermal necrolysis», or «hepatocutaneous syndrome».

The mildest form of skin reaction to spot - on products is epidermal paresthesia, which is defined as an abnormal sensation such as an itch or prickling of the skin.

The mildest form of skin reaction to spot - on products is epidermal paresthesia, which is defined as an abnormal sensation such as an itch or prickling of the s...

In the present study, stomatal frequency is expressed as the stomatal index (SI), which is calculated as SI (%) = [SD / (SD + ED)-RSB- X 100, where SD is the stomatal density and ED is the epidermal cell density.

A doctor diagnosed Karen Bartlett with having a possibly fatal skin disease known as Stevens - Johnson Syndrome and toxic epidermal necrolysis (SJS / TEN).