A major challenge for assessing driver mutations, such
as epidermal growth factor receptor (EGFR) mutations, in advanced disease is the scarcity of suitable biopsy tissue for molecular testing.
Not exact matches
About 15 to 20 % of breast cancers are classified
as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen
receptor, the progesterone
receptor, and HER2 (a member of the
epidermal growth factor receptor family).
Researchers found that a combination of drugs — one targeting
epidermal growth factor receptor (EGFR) and one targeting tumor necrosis
factor (TNF)-- effectively blocks the cancer from using TNF
as an escape route.
Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the
epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such
as erlotinib, gefitinib and afatinib.
Alice Shaw recalls a signal moment in 2004 — just
as she was finishing her oncology fellowship at MIT — when scientists discovered that mutations in a gene for
epidermal growth factor receptor (EGFR) were the culprits in about 10 to 15 percent of lung cancer patients.
RNA interference screen identifies Usp18
as a regulator of
epidermal growth factor receptor synthesis.
With this technology, they could watch for responses
as cancer cells responded to signals from EGFR (
epidermal growth factor receptor).
In addition to RIPK2 binding
as part of this computer - based (initial) screening, we selected compounds that inhibited
epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously identified RIPK2 inhibitors.
We are using the
epidermal growth factor receptor (EGFR)
as a model «endocytic system» to address these issues.
Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice
as likely
as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen
receptor (ER), progesterone
receptor (PR), and human
epidermal growth factor receptor 2 (HER - 2).
In vivo, breast cancer
growth is regulated by estrogens and peptide
growth factors, such
as epidermal growth factor (EGF), the
receptor of which has intrinsic PTK activity.