Sentences with phrase «as epigenetic»

Instead they have found that the nutrition available to our grandparents can have a profound affect on our health and longevity via what are known as epigenetic changes.

Studies in animals have shown that changes in diet can alter the function of genes — known as epigenetic change.

As an epigenetic toxicant, mercury can cause a host of metabolic issues, including blood sugar problems, insulin resistance and stress intolerance.

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention.

But many of the drugs currently being studied as epigenetic anticancer therapies may have indiscriminate effects.

116/2: 45 Williams - Beuren syndrome as an epigenetic disease: Association of GTF2IRD1 with chromatin silencing complexes.

Much attention worldwide is now focused on the histone tails and the proposition that patterns of covalent modifications serve as an epigenetic code.

Chromatin structure and function as well as epigenetic processes play key roles in regulating pluripotency and early differentiation events.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

Projects also address potential approaches to therapeutic genome editing, as well as epigenetic modifications to control gene expression.

A newer and more informative measure is known as the epigenetic clock.

Evidence suggests that estrogenic compounds appear to alter the ability of genes to function properly, a phenomenon referred to as epigenetic changes.

Many researchers believe that these changes can be passed down through sperm and eggs — a mechanism known as epigenetic inheritance.

This altered expression that does not correlate with changes in the base sequence is known as epigenetic regulation (as opposed to genetic regulation).

It's the first time anyone has identified changes in these chemical tags — known as epigenetic changes — in the sperm of obese men, he says.

«Our environment affects our genetic expression, which is usually referred to as epigenetic change.

For instance, malnutrition in early life as a result of poor nutrition during pregnancy and / or the lactation period may be stored on the offspring genome as epigenetic memory and persist into adulthood, thereby increasing the susceptibility to metabolic diseases such as obesity in later life.

The phenomenon is known as epigenetic inheritance.

As epigenetic changes to genes can be profound and durable, it is entirely likely they are involved in human disease.

In Dr. De Carvalho's research, the team discovered that this drug — known as an epigenetic therapy because it chemically modifies DNA — activates a pathway that recognizes viruses.

This is the first study to identify histone crotonylation as a driver for HIV transcription and de-crotonylation of histone as an epigenetic marker for HIV silencing.»

Many suspect these changes can pass on to offspring through sperm and eggs, a mechanism known as epigenetic inheritance.

There are more than 100 varieties of these chemical tags, collectively known as epigenetic marks.

On the outside of the heterochromatin bundles are chemical markers, known as epigenetic tags, which control the structure of the heterochromatin.

For a plant to create reproductive cells, it must first erase a key code, a series of tags attached to DNA across the genome known as epigenetic marks.

But he doesn't think it poses any challenge to standard evolutionary theory as the epigenetic change is itself most likely a result of a genetic change.

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features — chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes.

This process is known as epigenetic methylation.

Most notably, immune - mediated diseases are expected to be significantly influenced by such reagents as epigenetic changes have been widely noted to influence the immune system.

This is what is known as an epigenetic, rather than genetic, change.

This discrepancy suggests that other hereditary factors also play a role, such as epigenetic changes in the genetic material, including DNA methylation.

That's good news, as epigenetic modifications — unlike mutations — are in principle reversible.

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence.

«At this time, when prescription opioid use and opioid overdoses are both major threats to our public health, it is important to identify new treatment targets, such as epigenetic processes, that help to change the way that we do business in treating opioid use disorders,» said professor John Krystal, Editor of Biological Psychiatry.

Speaking as the epigenetic symposium commenced Professor John Hobcraft of the University of York, the lead scientific organiser of the Symposium, said: «Research is beginning to indicate how environmental and social factors are linked to a series of epigenetic changes, sometimes across quite broad areas of the genome.

Thus evolution was interpreted as epigenetic, as technical jargon put it; it was not merely or only the mechanical rearrangement of bits of matter.

This process of restricting the use of genetic information during embryonic development is known as epigenetic programming» programming that is not part of the DNA code itself but imposed on that code during embryonic development.

Chemical modifications such as DNA methylation control mammalian genes, serving as bookmarks for when a gene should be used — a phenomenon known as epigenetics.

It is only now, more than three decades later, that science has the tools to see that this legacy of trauma becomes etched in our DNA — a process known as epigenetics, in which environmental factors trigger genetic changes that may be passed on, just as surely as blue eyes and crooked smiles.

The year's most stunning revelations emerged in the fall, in four papers examining how RNA interference helps pilot a peculiar — and pervasive — genetic phenomenon known as epigenetics.

Chromatin is a complex formed by DNA and histones — proteins tightly bound to DNA — packaging it into chromosomes and determining gene expression, a process known as epigenetics.

In recent years researchers have learned that trauma can be inherited — passed down due to changes in DNA, what's known as epigenetics.

More recently, researchers have discovered that molecules can clamp onto DNA and prevent some parts of the sequence from being read, leading to genetic changes through a process that is known as epigenetics.

We have known for some time that it's not only the sequence of the DNA that is important; the physical scaffold, organization, and regulation of the DNA is also key and is known as epigenetics.

And we think that the regulation of those cells that results in behaving as if we are in a chronic stress kind of environment is explained by this field that's burgeoning right now that's referred to as epigenetics that talks about the programming of our cells.

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Just as the flow of a stream is determined by a specific landscape, so it seems that the growth and development of the proteins follow an «epigenetic landscape» which is extraneous to the physico - chemical forces that energize the growth process.8 And just as the geographical landscape is extraneous to the flow of water by the power of gravitation, so the epigenetic landscape is extraneous to the «flow» of energized matter operating by physico - chemical forces in the organism's epigenesis.

It must be admitted that epigenetic models lead to difficulties, because they postulate the emergence of qualities, such as life and mind, in evolving systems which did not possess them at all.

Embryonic stem cells are produced during development by the same process of epigenetic programming that later will produce adult cells such as skin and brain.

Indeed, the ability to clone animals, such as Dolly the sheep, by fusion of an adult cell to an enucleated oocyte demonstrates that the epigenetic programming responsible for maintaining an adult cell in a stable state can be erased by factors present in the cytoplasm of the oocyte.