Sentences with phrase «as epigenetic control»

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Chemical modifications such as DNA methylation control mammalian genes, serving as bookmarks for when a gene should be used — a phenomenon known as epigenetics.

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence.

On the outside of the heterochromatin bundles are chemical markers, known as epigenetic tags, which control the structure of the heterochromatin.

But as you said, as an individual eats a high - fat diet or is exposed to other types of environmental exposures, the ability of the liver to adapt involves turning on and turning off certain liver genes to control the liver's activity, and that's mediated through these epigenetic mechanisms that modify the activity of established liver genes.

That includes fundamental questions about organisms» growth, development, and regeneration, such as how the epigenetic code works to control tissue function, he says.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

Projects also address potential approaches to therapeutic genome editing, as well as epigenetic modifications to control gene expression.

Collaborating with the labs of Salk Professors Joseph Ecker and Alan Saghatelian, the Izpisua Belmonte team performed extensive characterization of the new cells and found rsPSCs showed distinct molecular and metabolic characteristics as well as novel epigenetic signatures — that is, patterns of chemical modifications to DNA that control which genes are turned on or off without changing the DNA sequence.

As a partner of the European Consortium 3D - REPERTOIRE and coordinator of the Spanish Structural Genomics Consortium GENES, our group studies several protein complexes and molecular machines, some of which are related to the epigenetic control of gene expression.

Studying the epigenetic setting of germ cells allows investigating several crucial aspects of mammalian biology such as transposon control, genomic imprinting and early lineage commitment.

The researchers used the inactive leg as a control, and took leg muscle biopsies to evaluate epigenetic methylation that occurred between the start and end of the study.