This process of restricting the use of genetic information during embryonic development is known
as epigenetic programming» programming that is not part of the DNA code itself but imposed on that code during embryonic development.
Not exact matches
Embryonic stem cells are produced during development by the same process of
epigenetic programming that later will produce adult cells such
as skin and brain.
Indeed, the ability to clone animals, such
as Dolly the sheep, by fusion of an adult cell to an enucleated oocyte demonstrates that the
epigenetic programming responsible for maintaining an adult cell in a stable state can be erased by factors present in the cytoplasm of the oocyte.
«
Epigenetics can be thought of
as the software that
programs function into the DNA hardware,» McDonald said.
Yi Zhang, who studies
epigenetics at Harvard Medical School in Boston, Massachusetts, and who has been using Saitou's method, has also found that in vitro PGCs do not erase their previous
epigenetic programming as well
as naturally occurring PGCs.
Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority
Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the
epigenetic factor EZH2 controls genes that govern tumor growth
as well
as genes that are important for the formation of metastases.
And we think that the regulation of those cells that results in behaving
as if we are in a chronic stress kind of environment is explained by this field that's burgeoning right now that's referred to
as epigenetics that talks about the
programming of our cells.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and
epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging),
as well
as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020
program), to develop a predictive modeling platform of signaling pathways involved in cancers.
Biologists often view cancer primarily
as a genetic
program gone wrong, with mutations and
epigenetic changes producing cells that don't behave the way they should: Genes associated with cell division and growth may be turned up, and genes for
programmed cell death may be turned down.
Steven Baylin's
epigenetics research is recognized by the National Cancer Institute
as the most outstanding in its SPORE (Specialized
Program of Research Excellence).
Recent theorizing within this tradition suggests that these shifts may be manifested in changes in the relative frequency of particular cell types in blood (Irwin and Cole, 2011)
as well
as in the
epigenetic programming and gene expression of such cells (Miller et al., 2011a).
More specifically,
epigenetic programming of cells would allow them to show more pronounced inflammatory responses when exposed to challenge (Miller et al., 2011a), an effect that has been observed in primate models (Cole et al., 2012),
as well
as in humans (Irwin and Cole, 2011).
The individuals» rhythms and the attraction to others» rhythms
as regulators may be an
epigenetic programming phenomenon, suggesting both genetic and early experience effects that endure across development.