Sentences with phrase «as epithelial»

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

Not exact matches

Vitamin A also maintains epithelial cells, which are responsible for keeping body surfaces healthy so that they can act as barriers to infection.

Vit A is required for normal vision, for maintaining the integrity and normal functioning of glandular and epithelial tissue, for skeletal growth, for maintenance of immunity, and for protection against certain cancers such as bronchial cancer.

The use of hydrogels dressings is a concept stolen from disciplines such as geriatrics, where patients suffer bed wounds and these water - based polymer matrix dressings are applied to maintain moisture, inhibit scab or crust formation, reduce pain, and enhance epithelial migration for wound repair.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

The new study links UVB as protective to a total of 16 types of cancer, primarily epithelial (pertaining to the surface) cancers of the digestive and reproductive systems [Grant, submitted].

Milk sodium concentration is a marker of tight junction closure between mammary epithelial cells; with the onset of secretory activation (stage II lactogenesis) milk sodium concentrations decrease sharply as potassium concentrations increase [14].

Colostrum is characteristically high in sodium (> 30 mmol / L) and low in potassium (< 15 mmol / L) as a result of open paracellular pathways between mammary epithelial cells [14].

As lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of faAs lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of faas membrane - bound globules of fat.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

People infected with HIV have few signs of microbial translocation during the first six months of infection as it takes time for the virus to kill off epithelial cells and weaken the gut wall so that bacteria can leak through — so treating them early could be more effective.

In this case, AAV acts as a Trojan horse and leads epithelial cells in the airways to make the antibodies; the question is how long they will continue doing so.

In the new study, DrugPredict suggested non-steroidal anti-inflammatory drugs, also known as NSAIDs, could have applications for epithelial ovarian cancer.

Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising «analogs» of an old compound that was once studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.

But he did isolate another group of simple salivary compounds — the histatins — that caused epithelial scratches to close up to twice as quickly as normal.

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

«These results showed us that epithelial TRPV1 normally works as a tumor suppressor in the intestines,» said de Jong.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

«In the initial phase, epithelial cells act as non-professional phagocytes to clear up milk protein and milk fat globules.

Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person.

Alix therefore functions as a «molecular bridge» that also determines the polarity of individual epithelial cells, namely the way cells are oriented with respect to one another within the epithelial cell layer.

With the passage of time, patches of retinal pigment epithelial cells may die, resulting in bare spots known as geographic atrophy.

In the normal cells, PDX1 maintains the cells» identity as pancreas cells and epithelial cells.

Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease.

The similarities led MBI Principal Investigator, Associate Professor Ronen Zaidel - Bar and graduate student Ms Tan Pei Yi to use the spermatheca as a model to study epithelial tube contraction.

As an important prerequisite for tube formation, epithelial cells become asymmetric or «polar», acquiring structurally and functionally distinct ends or surfaces.

Additional research will show whether other epithelial cells such as skin also partake of this self - healing method.

Factors such as gender, smoking, asbestos exposure and disease stage did not have an effect on whether patient's disease was positive for PD - L1 expression, but researchers did find that expression of the protein was more common in non-epithelial tumours compared to epithelial tumours.

The outermost layer of our skin is composed of dead squamous epithelial cells, as are the mucous membranes lining the inside of mouths and body cavities

In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over time.

Interestingly, CD44 + / CD24 − population can be generated by induction of epithelial — mesenchymal transition (EMT) by treating breast epithelial cells with EMT - inducing agents such as TGF - β1 (6).

The study team assessed three sets of outcomes: a maturational index (MI) based on epithelial cells from the children's urogenital tissue; ultrasound measurements of uterine, ovarian and testicular volume, as well as breast - buds; and hormone concentrations seen in blood tests.

Central to adherens junctions is a protein known as E-cadherin, or epithelial cadherin.

A549 (human lung adenocarcinoma) and BSC - 1 (African green monkey kidney epithelial) cell lines as well as PMK (primary rhesus monkey kidney) cells are routinely maintained at the Viral and Rickettsial Disease Laboratory (VRDL) branch of the California Department of Public Health.

Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is still an unmet biomedical challenge, because once chronic lesions have manifested, no effective therapies are available as of yet for clinical use.

Time - lapse movie of zebrafish lens epithelial cells expressing GFP - histones and mCherry - zGem as they progress through the cell cycle.

First, a hair follicle contains epithelial cells — a cell type that lines the body's vessels and cavities — as well as a specific kind of adult stem cell called dermal papillae.

Density is measured according to the ratio of connective and epithelial tissue, which appears on a mammogram as white, as compared to fatty tissue, which appears as black.

Such a depot or niche of endothelial stem - like cells would be analogous to the epithelial stem cells located in the anterior limbus that supply cells to the basal epithelium as transient amplifying cells, the cells that become committed to the state of terminal differentiation [11,15].

We are studying these proteins in the intestine and liver in vivo, as well as in epithelial cell lines.

BALB / c corneal epithelial and endothelial cell cultures were established as described previously (23).

When normal cells are transformed into cancer cells, this epithelial tissue can take on the characteristics of embryonic tissue, known as mesenchymal tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized tissues.

As you mentioned, in dry AMD we basically have atrophy in the back of the retina in cells that are called retinal pigment epithelial cells.

Epithelial organs can serve as a central hub where the host interacts with its environment, responds to it in a dynamic manner, and relays information throughout the body.

Subsequent studies, as reviewed by Daniels et al. [11] and Lavker and Sun [12] showed that some cells located in the anterior limbus are stem cells which partially differentiate into transient amplifying cells while migrating centrally into the posterior epithelial layer of the cornea.

A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis.