Sentences with phrase «as epithelial cells»

Not exact matches

Vitamin A also maintains epithelial cells, which are responsible for keeping body surfaces healthy so that they can act as barriers to infection.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

Milk sodium concentration is a marker of tight junction closure between mammary epithelial cells; with the onset of secretory activation (stage II lactogenesis) milk sodium concentrations decrease sharply as potassium concentrations increase [14].

Colostrum is characteristically high in sodium (> 30 mmol / L) and low in potassium (< 15 mmol / L) as a result of open paracellular pathways between mammary epithelial cells [14].

As lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of faAs lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of faas membrane - bound globules of fat.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

People infected with HIV have few signs of microbial translocation during the first six months of infection as it takes time for the virus to kill off epithelial cells and weaken the gut wall so that bacteria can leak through — so treating them early could be more effective.

In this case, AAV acts as a Trojan horse and leads epithelial cells in the airways to make the antibodies; the question is how long they will continue doing so.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

«In the initial phase, epithelial cells act as non-professional phagocytes to clear up milk protein and milk fat globules.

Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person.

Alix therefore functions as a «molecular bridge» that also determines the polarity of individual epithelial cells, namely the way cells are oriented with respect to one another within the epithelial cell layer.

With the passage of time, patches of retinal pigment epithelial cells may die, resulting in bare spots known as geographic atrophy.

In the normal cells, PDX1 maintains the cells» identity as pancreas cells and epithelial cells.

As an important prerequisite for tube formation, epithelial cells become asymmetric or «polar», acquiring structurally and functionally distinct ends or surfaces.

Additional research will show whether other epithelial cells such as skin also partake of this self - healing method.

The outermost layer of our skin is composed of dead squamous epithelial cells, as are the mucous membranes lining the inside of mouths and body cavities

In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over time.

Interestingly, CD44 + / CD24 − population can be generated by induction of epithelial — mesenchymal transition (EMT) by treating breast epithelial cells with EMT - inducing agents such as TGF - β1 (6).

The study team assessed three sets of outcomes: a maturational index (MI) based on epithelial cells from the children's urogenital tissue; ultrasound measurements of uterine, ovarian and testicular volume, as well as breast - buds; and hormone concentrations seen in blood tests.

A549 (human lung adenocarcinoma) and BSC - 1 (African green monkey kidney epithelial) cell lines as well as PMK (primary rhesus monkey kidney) cells are routinely maintained at the Viral and Rickettsial Disease Laboratory (VRDL) branch of the California Department of Public Health.

Time - lapse movie of zebrafish lens epithelial cells expressing GFP - histones and mCherry - zGem as they progress through the cell cycle.

First, a hair follicle contains epithelial cells — a cell type that lines the body's vessels and cavities — as well as a specific kind of adult stem cell called dermal papillae.

Such a depot or niche of endothelial stem - like cells would be analogous to the epithelial stem cells located in the anterior limbus that supply cells to the basal epithelium as transient amplifying cells, the cells that become committed to the state of terminal differentiation [11,15].

We are studying these proteins in the intestine and liver in vivo, as well as in epithelial cell lines.

BALB / c corneal epithelial and endothelial cell cultures were established as described previously (23).

When normal cells are transformed into cancer cells, this epithelial tissue can take on the characteristics of embryonic tissue, known as mesenchymal tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized tissues.

As you mentioned, in dry AMD we basically have atrophy in the back of the retina in cells that are called retinal pigment epithelial cells.

Subsequent studies, as reviewed by Daniels et al. [11] and Lavker and Sun [12] showed that some cells located in the anterior limbus are stem cells which partially differentiate into transient amplifying cells while migrating centrally into the posterior epithelial layer of the cornea.

A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis.

Results: Researchers at Pacific Northwest National Laboratory have identified the secretome — defined as the family of proteins secreted by cells — of human mammary epithelial cells, or HMEC.

The Joslin team found that intestinal tumors grow just as quickly in a mouse cancer model whose «epithelial» cells lining the inside of the intestine have been genetically modified so that insulin can't activate the cells.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

Long - lived cells such as cardiomyocytes, retinal pigmented epithelial cells and neurons are particularly dependent of the efficient function of their lysosomes to prevent the accumulation of damaged macromolecules over their extended lifetimes.

The degeneration of retinal pigment epithelial (RPE) cells as a consequence of impaired mitochondria has emerged as a key feature of early - stage age - related macular degeneration (AMD).

Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.

Protocols to grow organoids as polarized monolayers of epithelial cells on membranes or filters are already in place for the intestine, gall bladder, liver and pancreatic ducts (21).

Our Intestine - Chip also allows researchers to culture intestinal epithelial cells alongside other cell types, such as immune cells, and analyze how these different cell types interact.

Laminin - 111 is important during early epithelial development and differentiation of the epiblast, and is commonly used as a general attachment protein in cell culture.

Lastly, the trophoblast is a monolayer of cells, specifically polarized epithelial cells, which surround the blastocoel and ICM, similar to their future role of surrounding the fetus as its placenta (Rossant and Cross, 2001; Gilbert, 2003).

SDF - 1 is expressed in synovial epithelial cells and it has been reported that persistent induction of CXCR4 by stromal derived factors, such as TGF - β led to SDF - 1 mediated accumulation of CD4 T cells within the rheumatoid joint [44].

It involves isolation and propagation of adult epithelial stem cells, prepared from tissue specimens at different early stages of chronic and atrophic gastritis, as well as from the late, premalignant (irreversible) stage of metaplasia.

Human Prenatal Small Intestine Cells as a Valuable Source of Stem Cells and Epithelial Cells: Phenotypic and Functional Characterization.