Sentences with phrase «as epithelium»

These stem cells live in the lining of the intestine, known as the epithelium, and generate all of the different cell types that make up the epithelium.

As these epithelia mature, a tri-dimensional peripheral cell cord develops at the domain edge by differential extrusion, as a result of the additional degrees of freedom of the border cells.

Not exact matches

It is more profound in cancers that arise in tissues with a high turnover rate, such as the skin and the epithelium, the thin layer of cells that line many organs.

The retinal pigment epithelium (RPE) is a single layer of cells that accomplishes multiple functions, such as providing survival molecules that prevent photoreceptors from dying.

Since TMEM16A is expressed in the same epithelium as CFTR, its activation could restore hydration of the mucus layer.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

«Previous studies primarily focused on neurons and the retinal pigment epithelium cells as culprits in degeneration,» said Eroglu, who is also a member of the Duke Institute for Brain Sciences (DIBS).

They first identified a metabolite tilivalline as a critical enterotoxin, which in higher doses damages the intestinal epithelium and can induce colitis.

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in stratified epithelia such as the esophagus, skin or vagina.

As described in the article, when NANOG was increased in these mice, the epithelia showed an increase in cellular proliferation, hyperplasia, and an increase in the amount of DNA damage in the cells.

The current study just looked at cells of the epithelium, the layer of cells lining the gut, but there would be other cells responding to these microbial signals as well.

The middle layer is a one - cell - thick sheet known as the retinal pigment epithelium, or RPE.

Scientists, led by Ottar Rolfssonat the University of Iceland, have built a mathematical model to examine the metabolism of breast epithelium — as the majority of breast cancers originate from these cells.

Such a depot or niche of endothelial stem - like cells would be analogous to the epithelial stem cells located in the anterior limbus that supply cells to the basal epithelium as transient amplifying cells, the cells that become committed to the state of terminal differentiation [11,15].

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

The retinal neurons rely on their supporting cells, such as retinal pigment epithelium (RPE) cells, to provide them with the fuel to meet their energy needs.

The pathogenesis to gastric cancer is proposed by the Correa hypothesis as the transition from normal gastric epithelium to invasive cancer via inflammation followed by intramucosal cancer and invasion.

The lining or epithelium of the gut is one of the body's most diverse and dynamic tissues, an ecosystem of cells that acts as one of the body's main interfaces with the outside world.

Anatomically, the mucosa of the head and neck can be divided into a layer of stratified squamous epithelium and an underlying connective tissue layer known as the lamina propria (Table 2).

[13] Effector sites include areas such as the lamina propria, exocrine gland stroma, and surface epithelia, where mature lymphocytes perform their functions, such as releasing cytokines and secreting antibodies.

My lab is investigating basic mechanisms of patterning and morphogenesis in epithelia — we use the developing wing of drosophila as a model system and apply genetic, cell biological and physical tools to its analysis.

Histological examination at 150 days postnatal showed hNPC had formed a nearly continuous pigmented layer between the neural retina and retinal pigment epithelium, as well as distributed within the inner retina.

The Mfrp - C1qtnf5 dicistronic message is expressed in the RPE cells and in the ciliary epithelium, as well as the lens, but not in photoreceptors.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

These findings establish Frizzled family receptors as disease - relevant receptors for toxin B in the colonic epithelium and provide novel therapeutic targets for treating C. difficile infections.

The skin and other stratified epithelia as model tissues display a high turnover rate, and contain well - defined populations of adult stem cells (SCs).

The geometric homeostasis of mature epithelia observed at short enough time - scale thus raises the problem to understand how cells, if considered as noisy individual actuators, do adapt across individual intercellular contacts to locally balance their time - average contractile stress.

contain immunoprotective respiratory epithelium, the tissue lining the respiratory tract, which moistens and protects the airway and functions as a barrier to potential pathogens and foreign particles;

The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in stratified squamous epithelium [21,34].

Maintaining the composition of the beneficial intestinal microbiota requires a homeostatic equilibrium between the microbial community and the intestinal epithelium that serves as the regulatory...

Chlorella, activated charcoal, or N - acetyl cysteine can be prepared as a mouthwash where it binds to the mercury coating your oral epithelium.

These contribute not only to the prompt regeneration of tissue such as nerves and muscle, but also help to maintain the health of many organs and epithelia.

The succession of autoimmune diseases I developed due to a confluence of environmental triggers, genetic susceptibilities, and compromised gut barrier speak to the importance of preserving tight junction integrity and acting as a guardian of your gut epithelium.

The integrity of the epithelium of the esophagus, stomach as well as small and large bowels is essential in maintaining the balance of the microecology.

Glutamine is critical to intestinal health because it serves as the primary metabolic fuel for the rapidly dividing cells of intestinal epithelium.

These SCFA are the prime substrates for the energy metabolism in the colonocyte and they act as growth factors to the healthy epithelium.

Whole population cell kinetics of mouse duodenal, jejunal, ileal, and colonic epithelia as determined by radioautography and flow cytometry

Changes such as subpleural cysts lined by keratinizing squamous epithelium and extensive infectious sequelae are frequent in the lungs and are occasionally noted in the conjunctiva and salivary glands.

While drugs such as acetylcysteine are capable of breaking the disulphide bonds that are partially responsible for the particularly viscid nature of airway mucus, in practice, aerosolized acetlycysteine is irritating to airway epithelium and can promote significant bronchoconstriction.

Although the respiratory system signs are usually the most important, several signs related to pathology in other tissues with ciliated epithelia or microtubules can occur, such as otitis media, infertility in males and females, hydrocephalus, and renal fibrosis or dilation of renal tubules.

Total or generalized forms of retinal dysplasia have been described as an inherited trait in several breeds, including the Bedlington terrier [78], Sealyham terrier [79], Labrador retriever [80] and the Yorkshire terrier [81] and are associated with complete detachment of the abnormal neuroretina from the retinal pigment epithelium that results in blindness of affected eyes.

Overview: A superficial corneal ulcer is a defect or scratch in the topmost layer of the eye, the corneal epithelium — basically, think of this as the «skin» of the eye.